Survival and causes of death in adults with spina bifida in Sweden: a population-based case-control study

To analyse survival rates and causes of death in adults with spina bifida in Sweden compared with a matched control group. This population-based study included 11,900 adults born between 1950 and 1997. Three national Swedish registers were used to identify individuals with a diagnosis of spina bifid...

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Bibliographic Details
Published in:	Journal of rehabilitation medicine Vol. 55; p. jrm18244
Main Authors:	Rocchi, Melinda, Jarl, Johan, Lundkvist Josenby, Annika, Alriksson-Schmidt, Ann I
Format:	Journal Article
Language:	English
Published:	Sweden MJS Publishing, on behalf of the Foundation for Rehabilitation Information 27-11-2023 Medical Journals Sweden
Subjects:	Adult adults Case-Control Studies Cause of Death Clinical Medicine Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Health Sciences Humans Hälsovetenskap Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap mortality Neurologi Neurology Original Report Public Health, Global Health, Social Medicine and Epidemiology Research Design spina bifida Spinal Dysraphism survival Sweden - epidemiology transition to adult care Sweden
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Summary:	To analyse survival rates and causes of death in adults with spina bifida in Sweden compared with a matched control group. This population-based study included 11,900 adults born between 1950 and 1997. Three national Swedish registers were used to identify individuals with a diagnosis of spina bifida and a matched control group without spina bifida in the period 1990-2015. International Classification of Diseases codes were used to identify causes of death. Survival analysis was conducted and causes of death in the 2 groups were compared. There was a lower probability of survival for people with spina bifida in all age groups (p < 0.001) compared with the control group. The most prevalent causes of death in people with spina bifida were congenital, respiratory, nervous, cardiovascular, genitourinary, and injuries. People with spina bifida had a higher probability of dying from congenital (p < 0.001), respiratory (p = 0.002), genitourinary (p < 0.002), and nervous-related (p < 0.001) and lower probability of injury-related deaths (p < 0.001). Adults with spina bifida in Sweden have a lower survival rate compared with the general population, with the frequency of certain causes of death differing between the two groups. In order to reduce excess premature mortality, prevention and careful management of potentially fatal conditions are essential throughout a patient's lifespan.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1651-2081 1650-1977 1651-2081
DOI:	10.2340/jrm.v55.18244