Search Results - "Roccaro, Aldo M."

Targeting the bone marrow microenvironment in multiple myeloma by Kawano, Yawara, Moschetta, Michele, Manier, Salomon, Glavey, Siobhan, Görgün, Güllü T., Roccaro, Aldo M., Anderson, Kenneth C., Ghobrial, Irene M.

“…Summary Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in…”
Get full text

Prognostic role of circulating exosomal miRNAs in multiple myeloma by Manier, Salomon, Liu, Chia-Jen, Avet-Loiseau, Hervé, Park, Jihye, Shi, Jiantao, Campigotto, Federico, Salem, Karma Z., Huynh, Daisy, Glavey, Siobhan V., Rivotto, Bradley, Sacco, Antonio, Roccaro, Aldo M., Bouyssou, Juliette, Minvielle, Stéphane, Moreau, Philippe, Facon, Thierry, Leleu, Xavier, Weller, Edie, Trippa, Lorenzo, Ghobrial, Irene M.

“…Exosomes, secreted by several cell types, including cancer cells, can be isolated from the peripheral blood and have been shown to be powerful markers of…”
Get full text

Metabolic signature identifies novel targets for drug resistance in multiple myeloma by Maiso, Patricia, Huynh, Daisy, Moschetta, Michele, Sacco, Antonio, Aljawai, Yosra, Mishima, Yuji, Asara, John M, Roccaro, Aldo M, Kimmelman, Alec C, Ghobrial, Irene M

“…Drug resistance remains a major clinical challenge for cancer treatment. Multiple myeloma is an incurable plasma cell cancer selectively localized in the bone…”
Get full text

Multiple Myeloma and the Immune Microenvironment by Kawano, Yawara, Roccaro, Aldo M, Ghobrial, Irene M, Azzi, Jamil

“…One of the great advances in the field of cancer therapy in recent years is the emergence of immune therapies. Immune therapies, especially immune checkpoint…”
Get more information

Engineered nanomedicine for myeloma and bone microenvironment targeting by Swami, Archana, Reagan, Michaela R., Basto, Pamela, Mishima, Yuji, Kamaly, Nazila, Glavey, Siobhan, Zhang, Sufeng, Moschetta, Michele, Seevaratnam, Dushanth, Zhang, Yong, Liu, Jinhe, Memarzadeh, Masoumeh, Wu, Jun, Manier, Salomon, Shi, Jinjun, Bertrand, Nicolas, Lu, Zhi Ning, Nagano, Kenichi, Baron, Roland, Sacco, Antonio, Roccaro, Aldo M., Farokhzad, Omid C., Ghobrial, Irene M.

“…Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains…”
Get full text

C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma by Roccaro, Aldo M., Sacco, Antonio, Jimenez, Cristina, Maiso, Patricia, Moschetta, Michele, Mishima, Yuji, Aljawai, Yosra, Sahin, Ilyas, Kuhne, Michelle, Cardarelli, Pina, Cohen, Lewis, San Miguel, Jesus F., Garcia-Sanz, Ramon, Ghobrial, Irene M.

“…The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in modulating cell trafficking in hematopoietic stem cells and clonal B cells. We screened 418…”
Get full text

Regulation of microRNAs in cancer metastasis by Bouyssou, Juliette M.C., Manier, Salomon, Huynh, Daisy, Issa, Samar, Roccaro, Aldo M., Ghobrial, Irene M.

“…Metastasis is a phenomenon of crucial importance in defining prognosis in patients with cancer and is often responsible for cancer-related mortality. It is…”
Get full text

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation by Roccaro, Aldo M., Mishima, Yuji, Sacco, Antonio, Moschetta, Michele, Tai, Yu-Tzu, Shi, Jiantao, Zhang, Yong, Reagan, Michaela R., Huynh, Daisy, Kawano, Yawara, Sahin, Ilyas, Chiarini, Marco, Manier, Salomon, Cea, Michele, Aljawai, Yosra, Glavey, Siobhan, Morgan, Elizabeth, Pan, Chin, Michor, Franziska, Cardarelli, Pina, Kuhne, Michelle, Ghobrial, Irene M.

“…Extra-medullary disease (EMD) in multiple myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that…”
Get full text

Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study by Piva, Simone, DiBlasi, Robert M, Slee, April E, Jobe, Alan H, Roccaro, Aldo M, Filippini, Matteo, Latronico, Nicola, Bertoni, Michele, Marshall, John C, Portman, Michael A

“…COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The…”
Get full text

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features by Azab, Abdel Kareem, Hu, Jinsong, Quang, Phong, Azab, Feda, Pitsillides, Costas, Awwad, Rana, Thompson, Brian, Maiso, Patricia, Sun, Jessica D., Hart, Charles P., Roccaro, Aldo M., Sacco, Antonio, Ngo, Hai T., Lin, Charles P., Kung, Andrew L., Carrasco, Ruben D., Vanderkerken, Karin, Ghobrial, Irene M.

“…The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia…”
Get full text

SDF-1 inhibition targets the bone marrow niche for cancer therapy by Roccaro, Aldo M, Sacco, Antonio, Purschke, Werner G, Moschetta, Michele, Buchner, Klaus, Maasch, Christian, Zboralski, Dirk, Zöllner, Stefan, Vonhoff, Stefan, Mishima, Yuji, Maiso, Patricia, Reagan, Michaela R, Lonardi, Silvia, Ungari, Marco, Facchetti, Fabio, Eulberg, Dirk, Kruschinski, Anna, Vater, Axel, Rossi, Giuseppe, Klussmann, Sven, Ghobrial, Irene M

“…Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to…”
Get full text

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression by Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H, Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu J, Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P Leif, Roccaro, Aldo M, Azzi, Jamil, Ghobrial, Irene M

“…Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive…”
Get full text

Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia by Dogliotti, Irene, Jiménez, Cristina, Varettoni, Marzia, Talaulikar, Dipti, Bagratuni, Tina, Ferrante, Martina, Pérez, José, Drandi, Daniela, Puig, Noemí, Gilestro, Milena, García-Álvarez, María, Owen, Roger, Jurczak, Wojciech, Tedeschi, Alessandra, Leblond, Veronique, Kastritis, Efstathios, Kersten, Marie José, D’Sa, Shirley, Kaščák, Michal, Willenbacher, Wolfgang, Roccaro, Aldo M., Poulain, Stephanie, Morel, Pierre, Kyriakou, Charalampia, Fend, Falko, Vos, Josephine M. I., Dimopoulos, Meletios A., Buske, Christian, Ferrero, Simone, García-Sanz, Ramón

“…The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease…”
Get full text

Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model by Reagan, Michaela R., Mishima, Yuji, Glavey, Siobhan V., Zhang, Yong, Manier, Salomon, Lu, Zhi Ning, Memarzadeh, Masoumeh, Zhang, Yu, Sacco, Antonio, Aljawai, Yosra, Shi, Jiantao, Tai, Yu-Tzu, Ready, John E., Kaplan, David L., Roccaro, Aldo M., Ghobrial, Irene M.

“…Clonal proliferation of plasma cells within the bone marrow (BM) affects local cells, such as mesenchymal stromal cells (MSCs), leading to osteolysis and…”
Get full text

The cancer glycome: Carbohydrates as mediators of metastasis by Glavey, Siobhan V, Huynh, Daisy, Reagan, Michaela R, Manier, Salomon, Moschetta, Michele, Kawano, Yawara, Roccaro, Aldo M, Ghobrial, Irene M, Joshi, Lokesh, O'Dwyer, Michael E

“…Abstract Glycosylation is a frequent post-translational modification which results in the addition of carbohydrate determinants, “glycans”, to cell surface…”
Get full text

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma by Mishima, Yuji, Paiva, Bruno, Shi, Jiantao, Park, Jihye, Manier, Salomon, Takagi, Satoshi, Massoud, Mira, Perilla-Glen, Adriana, Aljawai, Yosra, Huynh, Daisy, Roccaro, Aldo M., Sacco, Antonio, Capelletti, Marzia, Detappe, Alexandre, Alignani, Diego, Anderson, Kenneth C., Munshi, Nikhil C., Prosper, Felipe, Lohr, Jens G., Ha, Gavin, Freeman, Samuel S., Van Allen, Eliezer M., Adalsteinsson, Viktor A., Michor, Franziska, San Miguel, Jesus F., Ghobrial, Irene M.

“…The development of sensitive and non-invasive “liquid biopsies” presents new opportunities for longitudinal monitoring of tumor dissemination and clonal…”
Get full text

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma by Glavey, Siobhan V., Manier, Salomon, Natoni, Alessandro, Sacco, Antonio, Moschetta, Michele, Reagan, Michaela R., Murillo, Laura S., Sahin, Ilyas, Wu, Ping, Mishima, Yuji, Zhang, Yu, Zhang, Wenjing, Zhang, Yong, Morgan, Gareth, Joshi, Lokesh, Roccaro, Aldo M., Ghobrial, Irene M., O'Dwyer, Michael E.

“…Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially…”
Get full text

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma by Roccaro, Aldo M., Sacco, Antonio, Thompson, Brian, Leleu, Xavier, Azab, Abdel Kareem, Azab, Feda, Runnels, Judith, Jia, Xiaoying, Ngo, Hai T., Melhem, Molly R., Lin, Charles P., Ribatti, Domenico, Rollins, Barrett J., Witzig, Thomas E., Anderson, Kenneth C., Ghobrial, Irene M.

“…Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple myeloma (MM) pathogenesis and disease progression. Nevertheless,…”
Get full text

LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas by Zhang, Yong, Roccaro, Aldo M., Rombaoa, Christopher, Flores, Ludmilla, Obad, Susanna, Fernandes, Stacey M., Sacco, Antonio, Liu, Yang, Ngo, Hai, Quang, Phong, Azab, Abdel Kareem, Azab, Feda, Maiso, Patricia, Reagan, Michaela, Brown, Jennifer R., Thai, To-Ha, Kauppinen, Sakari, Ghobrial, Irene M.

“…miR-155 acts as an oncogenic miR in B-cell lymphoproliferative disorders, including Waldenstrom macroglobulinemia (WM) and chronic lymphocytic leukemia, and is…”
Get full text

The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma by Giacomini, Arianna, Taranto, Sara, Gazzaroli, Giorgia, Faletti, Jessica, Capoferri, Davide, Marcheselli, Raffaella, Sciumè, Margherita, Presta, Marco, Sacco, Antonio, Roccaro, Aldo M

“…Among blood cancers, multiple myeloma (MM) represents the second most common neoplasm and is characterized by the accumulation and proliferation of monoclonal…”
Get full text