Search Results - "Roby, Justin A"

Post-translational regulation and modifications of flavivirus structural proteins by Roby, Justin A, Setoh, Yin Xiang, Hall, Roy A, Khromykh, Alexander A

“…Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally circulate between arthropod vectors and susceptible vertebrate hosts,…”
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Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity by Esser-Nobis, Katharina, Aarreberg, Lauren D, Roby, Justin A, Fairgrieve, Marian R, Green, Richard, Gale, Jr, Michael

“…In recent years, Asian lineage Zika virus (ZIKV) strains emerged to cause pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZVS)…”
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Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal by Hoad, Mikayla, Cross, Emily M, Donnelly, Camilla M, Sarker, Subir, Roby, Justin A, Forwood, Jade K

“…Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well…”
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MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity by Munasinghe, Thilini S., Edwards, Megan R., Tsimbalyuk, Sofiya, Vogel, Olivia A., Smith, Kate M., Stewart, Murray, Foster, Justin K., Bosence, Loretta A., Aragão, David, Roby, Justin A., Basler, Christopher F., Forwood, Jade K.

“…The MERS coronavirus (MERS-CoV) is a highly pathogenic, emerging virus that produces accessory proteins to antagonize the host innate immune response. The…”
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Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex by Donnelly, Camilla M, Stewart, Murray, Roby, Justin A, Sundaramoorthy, Vinod, Forwood, Jade K

“…Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In…”
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Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses by Roby, Justin A, Pijlman, Gorben P, Wilusz, Jeffrey, Khromykh, Alexander A

“…Flaviviruses are a large group of positive strand RNA viruses transmitted by arthropods that include many human pathogens such as West Nile virus (WNV),…”
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Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy by Burchill, Matthew A, Roby, Justin A, Crochet, Nanette, Wind-Rotolo, Megan, Stone, Amy E, Edwards, Michael G, Dran, Rachael J, Kriss, Michael S, Gale, Jr, Michael, Rosen, Hugo R

“…First, in patients receiving two different combinations of DAAs, we found that DAAs induced not only rapid viral clearance, but also a re-setting of antiviral…”
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Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism by Donnelly, Camilla M, Vogel, Olivia A, Edwards, Megan R, Taylor, Paige E, Roby, Justin A, Forwood, Jade K, Basler, Christopher F

“…Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the genus within the paramyxovirus family and are harbored by Flying Fox species…”
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Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling by Roby, Justin A, Esser-Nobis, Katharina, Dewey-Verstelle, Elyse C, Fairgrieve, Marian R, Schwerk, Johannes, Lu, Amy Y, Soveg, Frank W, Hemann, Emily A, Hatfield, Lauren D, Keller, Brian C, Shapiro, Alexander, Forero, Adriana, Stencel-Baerenwald, Jennifer E, Savan, Ram, Gale, Jr, Michael

“…Pathogenic flaviviruses antagonize host cell Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling downstream of interferons α/β…”
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING by Aarreberg, Lauren D., Esser-Nobis, Katharina, Driscoll, Connor, Shuvarikov, Andrey, Roby, Justin A., Gale, Michael

“…Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced in response to a wide range of stimuli. During infection, IL-1β production…”
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The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import by Tsimbalyuk, Sofiya, Cross, Emily M, Hoad, Mikayla, Donnelly, Camilla M, Roby, Justin A, Forwood, Jade K

“…Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host's innate immune response. The W protein is…”
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West Nile Virus Genome with Glycosylated Envelope Protein and Deletion of Alpha Helices 1, 2, and 4 in the Capsid Protein Is Noninfectious and Efficiently Secretes Subviral Particles by Roby, Justin A, Hall, Roy A, Khromykh, Alexander A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Correction: Tsimbalyuk et al. The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import. Cells 2020 , 9 , 1913 by Tsimbalyuk, Sofiya, Cross, Emily M, Hoad, Mikayla, Donnelly, Camilla M, Roby, Justin A, Forwood, Jade K

“…The authors would like to make the following corrections to the published paper [...]…”
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Structural basis for nuclear import of bat adeno-associated virus capsid protein by Hoad, Mikayla, Roby, Justin A, Forwood, Jade K

“…Adeno-associated viruses (AAV) are one of the world's most promising gene therapy vectors and as a result, are one of the most intensively studied viral…”
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Structural characterization of the porcine adeno‐associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha by Hoad, Mikayla, Roby, Justin A., Forwood, Jade K.

“…Adeno‐associated viruses (AAVs) are key vectors for gene therapy; thus, many aspects of their cell transduction pathway have been revealed in detail. However,…”
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RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions by Schwerk, Johannes, Soveg, Frank W., Ryan, Andrew P., Thomas, Kerri R., Hatfield, Lauren D., Ozarkar, Snehal, Forero, Adriana, Kell, Alison M., Roby, Justin A., So, Lomon, Hyde, Jennifer L., Gale, Michael, Daugherty, Matthew D., Savan, Ram

“…The initial response to viral infection is anticipatory, with host antiviral restriction factors and pathogen sensors constantly surveying the cell to rapidly…”
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Zika virus and the nonmicrocephalic fetus: why we should still worry by Walker, Christie L., Little, Marie-Térèse E., Roby, Justin A., Armistead, Blair, Gale, Michael, Rajagopal, Lakshmi, Nelson, Branden R., Ehinger, Noah, Mason, Brittney, Nayeri, Unzila, Curry, Christine L., Adams Waldorf, Kristina M.

“…Zika virus is a mosquito-transmitted flavivirus and was first linked to congenital microcephaly caused by a large outbreak in northeastern Brazil. Although the…”
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Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural–biological analysis by Selinger, Martin, Novotný, Radim, Sýs, Jakub, Roby, Justin A., Tykalová, Hana, Ranjani, Ganji Sri, Vancová, Marie, Jaklová, Kateřina, Kaufman, Filip, Bloom, Marshall E., Zdráhal, Zbyněk, Grubhoffer, Libor, Forwood, Jade K., Hrabal, Richard, Rumlová, Michaela, Štěrba, Ján

“…Tick-borne encephalitis virus (TBEV) is the most medically relevant tick-transmitted Flavivirus in Eurasia, targeting the host central nervous system and…”
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Endomembrane targeting of human OAS1 p46 augments antiviral activity by Soveg, Frank W, Schwerk, Johannes, Gokhale, Nandan S, Cerosaletti, Karen, Smith, Julian R, Pairo-Castineira, Erola, Kell, Alison M, Forero, Adriana, Zaver, Shivam A, Esser-Nobis, Katharina, Roby, Justin A, Hsiang, Tien-Ying, Ozarkar, Snehal, Clingan, Jonathan M, McAnarney, Eileen T, Stone, Amy El, Malhotra, Uma, Speake, Cate, Perez, Joseph, Balu, Chiraag, Allenspach, Eric J, Hyde, Jennifer L, Menachery, Vineet D, Sarkar, Saumendra N, Woodward, Joshua J, Stetson, Daniel B, Baillie, John Kenneth, Buckner, Jane H, Gale, Jr, Michael, Savan, Ram

“…Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified…”
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A scoping review of African swine fever virus spread between domestic and free‐living pigs by Brookes, Victoria J., Barrett, Tamille E., Ward, Michael P., Roby, Justin A., Hernandez‐Jover, Marta, Cross, Emily M., Donnelly, Camilla M., Barnes, Tamsin S., Wilson, Cara S., Khalfan, Shahid

“…Since 2007, African swine fever virus (ASFV) has spread to countries in Europe, Asia and Oceania and has caused devastating impacts on pigs and the pork…”
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