Search Results - "Robson, Michael I."

Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D by Robson, Michael I., Ringel, Alessa R., Mundlos, Stefan

“…During embryogenesis, precise gene transcription in space and time requires that distal enhancers and promoters communicate by physical proximity within gene…”
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Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis by Robson, Michael I., de las Heras, Jose I., Czapiewski, Rafal, Lê Thành, Phú, Booth, Daniel G., Kelly, David A., Webb, Shaun, Kerr, Alastair R.W., Schirmer, Eric C.

“…Whether gene repositioning to the nuclear periphery during differentiation adds another layer of regulation to gene expression remains controversial. Here, we…”
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Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers by Agirre, Xabier, Castellano, Giancarlo, Pascual, Marien, Heath, Simon, Kulis, Marta, Segura, Victor, Bergmann, Anke, Esteve, Anna, Merkel, Angelika, Raineri, Emanuele, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Russiñol, Nuria, Queirós, Ana C, Beekman, Renée, Rodríguez-Madoz, Juan R, San José-Enériz, Edurne, Fang, Fang, Gutiérrez, Norma C, García-Verdugo, José M, Robson, Michael I, Schirmer, Eric C, Guruceaga, Elisabeth, Martens, Joost H A, Gut, Marta, Calasanz, Maria J, Flicek, Paul, Siebert, Reiner, Campo, Elías, Miguel, Jesús F San, Melnick, Ari, Stunnenberg, Hendrik G, Gut, Ivo G, Prosper, Felipe, Martín-Subero, José I

“…While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a…”
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Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome by Czapiewski, Rafal, Robson, Michael I, Schirmer, Eric C

“…It is well established that the nuclear envelope has many distinct direct connections to chromatin that contribute to genome organization. The functional…”
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The nuclear envelope as a chromatin organizer by Zuleger, Nikolaj, Robson, Michael I., Schirmer, Eric C.

“…In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3…”
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Jumping retroviruses nudge TADs apart by Robson, Michael I., Mundlos, Stefan

“…Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study…”
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Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments by Robson, Michael I, de Las Heras, Jose I, Czapiewski, Rafal, Sivakumar, Aishwarya, Kerr, Alastair R W, Schirmer, Eric C

“…The 3D organization of the genome changes concomitantly with expression changes during hematopoiesis and immune activation. Studies have focused either on…”
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Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma by Helmsauer, Konstantin, Valieva, Maria E., Ali, Salaheddine, Chamorro González, Rocío, Schöpflin, Robert, Röefzaad, Claudia, Bei, Yi, Dorado Garcia, Heathcliff, Rodriguez-Fos, Elias, Puiggròs, Montserrat, Kasack, Katharina, Haase, Kerstin, Keskeny, Csilla, Chen, Celine Y., Kuschel, Luis P., Euskirchen, Philipp, Heinrich, Verena, Robson, Michael I., Rosswog, Carolina, Toedling, Joern, Szymansky, Annabell, Hertwig, Falk, Fischer, Matthias, Torrents, David, Eggert, Angelika, Schulte, Johannes H., Mundlos, Stefan, Henssen, Anton G., Koche, Richard P.

“…MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular…”
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Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator by Allou, Lila, Balzano, Sara, Magg, Andreas, Quinodoz, Mathieu, Royer-Bertrand, Beryl, Schöpflin, Robert, Chan, Wing-Lee, Speck-Martins, Carlos E., Carvalho, Daniel Rocha, Farage, Luciano, Lourenço, Charles Marques, Albuquerque, Regina, Rajagopal, Srilakshmi, Nampoothiri, Sheela, Campos-Xavier, Belinda, Chiesa, Carole, Niel-Bütschi, Florence, Wittler, Lars, Timmermann, Bernd, Spielmann, Malte, Robson, Michael I., Ringel, Alessa, Heinrich, Verena, Cova, Giulia, Andrey, Guillaume, Prada-Medina, Cesar A., Pescini-Gobert, Rosanna, Unger, Sheila, Bonafé, Luisa, Grote, Phillip, Rivolta, Carlo, Mundlos, Stefan, Superti-Furga, Andrea

“…Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory networks 1 , but the exact nature and extent of their involvement in human…”
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Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes by Ringel, Alessa R, Szabo, Quentin, Chiariello, Andrea M, Chudzik, Konrad, Schöpflin, Robert, Rothe, Patricia, Mattei, Alexandra L, Zehnder, Tobias, Harnett, Dermot, Laupert, Verena, Bianco, Simona, Hetzel, Sara, Glaser, Juliane, Phan, Mai H Q, Schindler, Magdalena, Ibrahim, Daniel M, Paliou, Christina, Esposito, Andrea, Prada-Medina, Cesar A, Haas, Stefan A, Giere, Peter, Vingron, Martin, Wittler, Lars, Meissner, Alexander, Nicodemi, Mario, Cavalli, Giacomo, Bantignies, Frédéric, Mundlos, Stefan, Robson, Michael I

“…Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and…”
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Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation by Lister, Nicholas C, Milton, Ashley M, Patel, Hardip R, Waters, Shafagh A, Hanrahan, Benjamin J, McIntyre, Kim L, Livernois, Alexandra M, Horspool, William B, Wee, Lee Kian, Ringel, Alessa R, Mundlos, Stefan, Robson, Michael I, Shearwin-Whyatt, Linda, Grützner, Frank, Graves, Jennifer A Marshall, Ruiz-Herrera, Aurora, Waters, Paul D

“…Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long…”
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The Application of DamID to Identify Peripheral Gene Sequences in Differentiated and Primary Cells by Robson, Michael I, Schirmer, Eric C

“…The nuclear envelope interacts extensively with chromatin, though with differences in degree and specificity in different cell types. However, identifying the…”
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Immunohistochemistry on a panel of emery-dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology by Le Thanh, Phu, Meinke, Peter, Korfali, Nadia, Srsen, Vlastimil, Robson, Michael I, Wehnert, Manfred, Schoser, Benedikt, Sewry, Caroline A, Schirmer, Eric C

“…Highlights • Altered distribution of EDMD-linked proteins is not a general disease characteristic • Tissue-specific proteins exhibit altered distributions in…”
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The NEMP family supports metazoan fertility and nuclear envelope stiffness by Tsatskis, Yonit, Rosenfeld, Robyn, Pearson, Joel D, Boswell, Curtis, Qu, Yi, Kim, Kyunga, Fabian, Lacramioara, Mohammad, Ariz, Wang, Xian, Robson, Michael I, Krchma, Karen, Wu, Jun, Gonçalves, João, Hodzic, Didier, Wu, Shu, Potter, Daniel, Pelletier, Laurence, Dunham, Wade H, Gingras, Anne-Claude, Sun, Yu, Meng, Jin, Godt, Dorothea, Schedl, Tim, Ciruna, Brian, Choi, Kyunghee, Perry, John R B, Bremner, Rod, Schirmer, Eric C, Brill, Julie A, Jurisicova, Andrea, McNeill, Helen

“…Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in ( ) with early menopause; however, it is unclear whether NEMP1 has…”
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NETs and cell cycle regulation by Robson, Michael I, Le Thanh, Phu, Schirmer, Eric C

“…There are many ways that the nuclear envelope can influence the cell cycle. In addition to roles of lamins in regulating the master cell cycle regulator pRb…”
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Whole-Genome Epigenomic Analysis in Multiple Myeloma Reveals DNA Hypermethylation of B-Cell Specific Enhancers by Agirre, Xabier, Castellano, Giancarlo, Pascual, Marien, Health, Simon, Kulis, Marta, Segura, Victor, Bergmann, Anke, Esteve, Anna, Merkel, Angelika, Raineri, Emanuele, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Russiñol, Nuria, Queirós, Ana C., Beekman, Renée, Rodriguez-Madoz, Juan R., San José-Enériz, Edurne, Fang, Fang, Gutierrez, Norma Carmen, García-Verdugo, José M, Robson, Michael I., Schirmer, Eric C., Guruceaga, Elisabeth, Martens, Joost H.A., Gut, Marta, Calasanz, María José, Flicek, Paul, Siebert, Reiner, Campo, Elias, San Miguel, Jesus F., Melnick, Ari M, Stunnenberg, Hendrik G., Gut, Ivo G., Prosper, Felipe, Martín-Subero, Jose Ignacio

“…Analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed…”
Get full text