Search Results - "Robles, Andrew J"

Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity by Du, Lin, Robles, Andrew J., King, Jarrod B., Powell, Douglas R., Miller, Andrew N., Mooberry, Susan L., Cichewicz, Robert H.

“…A fundamental component for success in drug discovery is the ability to assemble and screen compounds that encompass a broad swath of biologically relevant…”
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Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3- d ]pyrimidines as Microtubule Targeting Agents by Islam, Farhana, Doshi, Arpit, Robles, Andrew J, Quadery, Tasdique M, Zhang, Xin, Zhou, Xilin, Hamel, Ernest, Mooberry, Susan L, Gangjee, Aleem

“…A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3- ]pyrimidines were designed and synthesized and their biological activities were…”
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PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair by Cropper, Jodie D, Alimbetov, Dauren S, Brown, Kevin T. G, Likhotvorik, Rostislav I, Robles, Andrew J, Guerra, James T, He, Boxue, Chen, Yidong, Kwon, Youngho, Kurmasheva, Raushan T

“…Abstract DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1…”
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PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma by Del Pozo, Vanessa, Robles, Andrew J., Fontaine, Shaun D., Liu, Qianqian, Michalek, Joel E., Houghton, Peter J., Kurmasheva, Raushan T.

“…Current therapy is ineffective for relapsed and metastatic Ewing sarcoma (EwS) owing to development of drug resistance. Macromolecular prodrugs potentially…”
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Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4 by Ullevig, Sarah L, Kim, Hong Seok, Nguyen, Huynh Nga, Hambright, William S, Robles, Andrew J, Tavakoli, Sina, Asmis, Reto

“…Dietary supplementation with ursolic acid (UA) prevents monocyte dysfunction in diabetic mice and protects mice against atherosclerosis and loss of renal…”
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Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site by Choudhary, Shruti, Kaku, Krishna, Robles, Andrew J., Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem

“…Simple Monocyclic Pyrimidine Analogs as Microtubule Targeting Agents Binding to the Colchicine Site. Structural simplification of pyrrolo[2,3–d]pyrimidine…”
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Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer by Robles, Andrew J., Cai, Shengxin, Cichewicz, Robert H., Mooberry, Susan L.

“…Triple-negative breast cancers (TNBC) are aggressive malignancies with no effective targeted therapies. Recent gene expression profiling of these heterogeneous…”
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Structure–Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells by Robles, Andrew J, McCowen, Shelby, Cai, Shengxin, Glassman, Michaels, Ruiz, Francisco, Cichewicz, Robert H, McHardy, Stanton F, Mooberry, Susan L

“…Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers…”
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Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer by Robles, Andrew J, Du, Lin, Cichewicz, Robert H, Mooberry, Susan L

“…Triple-negative breast cancers are highly aggressive, and patients with these types of tumors have poor long-term survival. These breast cancers do not express…”
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Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts by Robles, Andrew J, Kurmasheva, Raushan T, Bandyopadhyay, Abhik, Phelps, Doris A, Erickson, Stephen W, Lai, Zhao, Kurmashev, Dias, Chen, Yidong, Smith, Malcom A, Houghton, Peter J

“…Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in treatment of…”
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Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ by Risinger, April L, Li, Jing, Du, Lin, Benavides, Raymond, Robles, Andrew J, Cichewicz, Robert H, Kuhn, John G, Mooberry, Susan L

“…The taccalonolides are microtubule stabilizers that covalently bind tubulin and circumvent clinically relevant forms of resistance to other drugs of this…”
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Cytotoxic Dimeric Epipolythiodiketopiperazines from the Ascomycetous Fungus Preussia typharum by Du, Lin, Robles, Andrew J, King, Jarrod B, Mooberry, Susan L, Cichewicz, Robert H

“…Two new dimeric epipolythiodiketopiperazines, preussiadins A (1) and B (2), together with two known diastereomers, leptosins C (6) and A (7), were obtained…”
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Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells by Shaffer, Corena V, Cai, Shengxin, Peng, Jiangnan, Robles, Andrew J, Hartley, Rachel M, Powell, Douglas R, Du, Lin, Cichewicz, Robert H, Mooberry, Susan L

“…There remains a critical need for more effective therapies for the treatment of late-stage and metastatic prostate cancers. Three Texas native plants yielded…”
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Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma by Robles, Andrew J, Dai, Wentao, Haldar, Saikat, Ma, Hongyan, Anderson, Victoria M, Overacker, Ross D, Risinger, April L, Loesgen, Sandra, Houghton, Peter J, Cichewicz, Robert H, Mooberry, Susan L

“…A screening program designed to identify natural products with selective cytotoxic effects against cell lines representing different types of pediatric solid…”
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Melampodium leucanthum, a Source of Cytotoxic Sesquiterpenes with Antimitotic Activities by Robles, Andrew J, Peng, Jiangnan, Hartley, Rachel M, Lee, Brigette, Mooberry, Susan L

“…A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known…”
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PARP1-MGMT complex underpins pathway crosstalk in O 6 -methylguanine repair by Cropper, Jodie D, Alimbetov, Dauren S, Brown, Kevin T G, Likhotvorik, Rostislav I, Robles, Andrew J, Guerra, James T, He, Boxue, Chen, Yidong, Kwon, Youngho, Kurmasheva, Raushan T

“…DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and…”
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Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity by Du, Lin, Robles, Andrew J., King, Jarrod B., Powell, Douglas R., Miller, Andrew N., Mooberry, Susan L., Cichewicz, Robert H.

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Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity by Du, Lin, Robles, Andrew J., King, Jarrod B., Powell, Douglas R., Miller, Andrew N., Mooberry, Susan L., Cichewicz, Robert H.

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Design, Synthesis and Cytotoxicity of Novel Chalcone Analogs Derived from 1-Cyclohexylpyrrolidin-2-one and 2,3-Dihydrobenzo[f]chromen-1-one by Brien, Kimberly A., Bandi, Ravi Kumar, Behera, Ajaya Kumar, Mishra, Bijay Kumar, Majumdar, Poulomi, Satam, Vijay, Savagian, Mia, Tzou, Samuel, Lee, Megan, Zeller, Matthias, Robles, Andrew J., Mooberry, Susan, Pati, Hari, Lee, Moses

“…Two divergent series of novel chalcone analogs, one derived from 1‐cyclohexylpyrrolidin‐2‐one and the other derived from 1‐benzo[f]chromanone, were designed,…”
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Berichtigung: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity by Du, Lin, Robles, Andrew J., King, Jarrod B., Powell, Douglas R., Miller, Andrew N., Mooberry, Susan L., Cichewicz, Robert H.

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