Search Results - "Roblegg, E."

Nano-sized and micro-sized polystyrene particles affect phagocyte function by Prietl, B., Meindl, C., Roblegg, E., Pieber, T. R., Lanzer, G., Fröhlich, E.

“…Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis,…”
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The design of controlled-release formulations resistant to alcohol-induced dose dumping – A review by Jedinger, N., Khinast, J., Roblegg, E.

“…The concomitant intake of alcoholic beverages together with oral controlled-release opioid formulations poses a serious safety concern since alcohol has the…”
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Comprehensive investigation of saliva replacement liquids for the treatment of xerostomia by Spirk, C., Hartl, S., Pritz, E., Gugatschka, M., Kolb-Lenz, D., Leitinger, G., Roblegg, E.

“…[Display omitted] The sensation of dry mouth also referred to as xerostomia is becoming increasingly common worldwide. Current treatment strategies include…”
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Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats by Gradauer, K., Barthelmes, J., Vonach, C., Almer, G., Mangge, H., Teubl, B., Roblegg, E., Dünnhaupt, S., Fröhlich, E., Bernkop-Schnürch, A., Prassl, R.

“…The aim of the present study was the in vivo evaluation of thiomer-coated liposomes for an oral application of peptides. For this purpose, salmon calcitonin…”
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Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings by Koutsamanis, I., Eder, S., Beretta, M., Witschnigg, A., Paudel, A., Nickisch, K., Friedrich, M., Eggenreich, K., Roblegg, E.

“…[Display omitted] The application of ethylene-vinyl acetate (EVA) copolymers in reservoir-type intra-vaginal rings (IVRs) offers advantages over silicones…”
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Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure by Planchette, C., Pichler, H., Wimmer-Teubenbacher, M., Gruber, M., Gruber-Woelfler, H., Mohr, S., Tetyczka, C., Hsiao, W.-K., Paudel, A., Roblegg, E., Khinast, J.

“…[Display omitted] We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a…”
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Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells by Jeitler, R, Glader, C, Tetyczka, C, Zeiringer, S, Absenger-Novak, M, Selmani, A, Fröhlich, E, Roblegg, E

“…Lipid-based nanosystems enable intracellular delivery of drugs in the oral cavity for the treatment of local diseases. To rationally design such systems,…”
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Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids by Jedinger, N., Schrank, S., Mohr, S., Feichtinger, A., Khinast, J., Roblegg, E.

“…[Display omitted] •Interactions between ethanol and lipophilic melt extruded pellets are investigated.•Dose dumping depends on matrix composition,…”
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Label-free in vitro visualization of particle uptake into human oral buccal epithelial cells by confocal Raman microscopy by Kann, B, Teubl, B J, Roblegg, E, Windbergs, M

“…In this study, we present confocal Raman microscopy for chemically selective analysis of a human buccal epithelial cell layer with a focus on label-free…”
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Injection molding as a one-step process for the direct production of pharmaceutical dosage forms from primary powders by Eggenreich, K., Windhab, S., Schrank, S., Treffer, D., Juster, H., Steinbichler, G., Laske, S., Koscher, G., Roblegg, E., Khinast, J.G.

“…[Display omitted] The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of…”
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The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: Pellet microstructure, drug distribution, solid state and drug dissolution by Schrank, S., Kann, B., Saurugger, E., Hainschitz, M., Windbergs, M., Glasser, B.J., Khinast, J., Roblegg, E.

“…[Display omitted] Although drying is widely applied during the manufacturing of solid dosage forms, its potential effect on the product’s (key) properties is…”
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Impact of Drying on Solid State Modifications and Drug Distribution in Ibuprofen-Loaded Calcium Stearate Pellets by Schrank, S, Kann, B, Saurugger, E, Ehmann, H, Werzer, O, Windbergs, M, Glasser, B. J, Zimmer, A, Khinast, J, Roblegg, E

“…Drying is a common pharmaceutical process, whose potential to alter the final drug propertieseven at relatively low temperaturesis often neglected. The…”
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Surface Induced Order of Solution Processed Caffeine Needles on Silica and Muscovite Mica by Werzer, O, Kunert, B, Roblegg, E, Zimmer, A, Oehzelt, M, Resel, R

“…In this work the orientational order of needle-shaped caffeine crystallites at silica and muscovite mica surfaces is investigated by X-ray diffraction…”
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Pharmacokinetics of a novel liquid controlled release codeine formulation by Dittrich, P., Beubler, E., Haltmeyer, K., Zimmer, A., Roblegg, E.

“…Codeine is an important opioid anti-tussive agent whose short half-life (2.9 ± 0.7 h) requires that it be administered at 4-h intervals when formulated as a…”
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79 The impact of inflammation on the absolute concentration of albumin and α1-acid glycoprotein in porcine skin by Schwingenschuh, S., Hofmann, E., Reisenegger, P., Joebstl, M., Heegaard, P.M.H., Schweiger, J., Prugger, E.-M., Ratzer, M., Eberl, A., Raml, R., Kotzbeck, P., Tetyczka, C., Roblegg, E., Birngruber, T.

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The oral cavity as a biological barrier system: Design of an advanced buccal in vitro permeability model by Teubl, Birgit J., Absenger, Markus, Fröhlich, Eleonore, Leitinger, Gerd, Zimmer, Andreas, Roblegg, Eva

“…Development of a physiological, buccal in vitro model for transport studies of nanoparticles. An “external” mucus layer was prepared by a film method and…”
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Revealing hidden molecular nanostructure details in the pellet formulation of ibuprofen by combining Synchrotron and laboratory sources by Hodzic, A., Birarda, G., Juraic, K., Sket, P., Eder, S., Kriechbaum, M., D'Amico, F., DeGiacomo, O., Roblegg, E.

“…Previous studies could report about different behavior of dried pellets at the 50°C due to the lack of constant rate period of drying. Now, one step further,…”
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Comparison of two in vitro systems to assess cellular effects of nanoparticles-containing aerosols by Fröhlich, Eleonore, Bonstingl, Gudrun, Höfler, Anita, Meindl, Claudia, Leitinger, Gerd, Pieber, Thomas R., Roblegg, Eva

“…► A new VITROCELL – Pariboy system was evaluated for testing of aerosolized NPs. ► Deposition rates differed between marker compounds and NPs. ► The manual…”
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Inline monitoring and a PAT strategy for pharmaceutical hot melt extrusion by Wahl, Patrick R., Treffer, Daniel, Mohr, Stefan, Roblegg, Eva, Koscher, Gerold, Khinast, Johannes G.

“…Monitoring of extrusion dynamics with in-line NIR spectroscopy. Implementation of continuous manufacturing in the pharmaceutical industry requires tight…”
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Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa by Roblegg, Eva, Fröhlich, Eleonore, Meindl, Claudia, Teubl, Birgit, Zaversky, Michaela, Zimmer, Andreas

“…Abstract A buccal physiological in vitro testing system for the evaluation of the permeability, the transport route and toxic effects of nanoparticles was…”
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