Search Results - "Robison, Patrick"

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes by Robison, Patrick, Caporizzo, Matthew A., Ahmadzadeh, Hossein, Bogush, Alexey I., Chen, Christina Yingxian, Margulies, Kenneth B., Shenoy, Vivek B., Prosser, Benjamin L.

“…The microtubule (MT) cytoskeleton can transmit mechanical signals and resist compression in contracting cardiomyocytes. How MTs perform these roles remains…”
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Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure by Chen, Christina Yingxian, Caporizzo, Matthew A., Bedi, Kenneth, Vite, Alexia, Bogush, Alexey I., Robison, Patrick, Heffler, Julie G., Salomon, Alex K., Kelly, Neil A., Babu, Apoorva, Morley, Michael P., Margulies, Kenneth B., Prosser, Benjamin L.

“…Detyrosinated microtubules provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of…”
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A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte by Heffler, Julie, Shah, Parisha P., Robison, Patrick, Phyo, Sai, Veliz, Kimberly, Uchida, Keita, Bogush, Alexey, Rhoades, Joshua, Jain, Rajan, Prosser, Benjamin L.

“…Mechanical forces are transduced to nuclear responses via the linkers of the nucleoskeleton and cytoskeleton (LINC) complex, which couples the cytoskeleton to…”
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Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle by Kerr, Jaclyn P., Robison, Patrick, Shi, Guoli, Bogush, Alexey I., Kempema, Aaron M., Hexum, Joseph K., Becerra, Natalia, Harki, Daniel A., Martin, Stuart S., Raiteri, Roberto, Prosser, Benjamin L., Ward, Christopher W.

“…In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species…”
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Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke‐induced mouse model of COPD by Robison, Patrick, Sussan, Thomas E., Chen, Hegang, Biswal, Shyam, Schneider, Martin F., Hernández‐Ochoa, Erick O.

“…ABSTRACT Introduction Respiratory and locomotor skeletal muscle dysfunction are common findings in chronic obstructive pulmonary disease (COPD); however, the…”
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Microtubule mechanics in the working myocyte by Robison, Patrick, Prosser, Benjamin L.

“…The mechanical role of cardiac microtubules (MTs) has been a topic of some controversy. Early studies, which relied largely on pharmacological interventions…”
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Desmin is Critical to the Nuclear Architecture of Cardiomyocytes by Robison, Patrick, Heffler, Julie, Jain, Rajan, Prosser, Benjamin

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Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte by Salomon, Alexander K., Phyo, Sai Aung, Okami, Naima, Heffler, Julie, Robison, Patrick, Bogush, Alexey I., Prosser, Benjamin L.

“…In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and impedes its contractile function…”
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Microtubule Bundles in the Adult Cardiomyocyte by Robison, Patrick, Bogush, Alexey I., Prosser, Benjamin L.

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Abstract 519: Desmin Protects Cardiomyocyte Nuclei From Microtubule-dependent Collapse by Heffler, Julie, Shah, Parisha P, Robison, Patrick, Phyo, Sai, Veliz, Kimberly, Bogush, Alexey, Rhoades, Joshua, Jain, Rajan, Prosser, Benjamin L

“…Abstract only Alterations to mechanical forces have been long-appreciated to be sufficient to drive cardiac pathophysiological remodeling; however, the…”
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Detyrosinated Microtubules Bear Load and Transmit Mechanical Force in Cardiomyocytes by Robison, Patrick, Caporizzo, Matthew, Bogush, Alexey, Margulies, Kenneth, Prosser, Benjamin

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Ultrastructural Surveys of Cardiomyocytes Isolated from Failing Human Hearts by Robison, Patrick, Yingxian Chen, Christina, Caporizzo, Matthew A., Bedi, Kenneth, Margulies, Kenneth B., Prosser, Benjamin L.

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Mechanical signaling coordinates the embryonic heartbeat by Chiou, Kevin K., Rocks, Jason W., Chen, Christina Yingxian, Cho, Sangkyun, Merkus, Koen E., Rajaratnam, Anjali, Robison, Patrick, Tewari, Manorama, Vogel, Kenneth, Majkut, Stephanie F., Prosser, Benjamin L., Discher, Dennis E., Liu, Andrea J.

“…In the beating heart, cardiac myocytes (CMs) contract in a coordinated fashion, generating contractile wave fronts that propagate through the heart with each…”
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Abstract 13: Suppressing Microtubule Detyrosination Reduces Stiffness and Improves Contractility in Human Cardiomyocytes by Prosser, Benjamin L, Bedi, Kenneth, Caporizzo, Matthew, Chen, Christina, Robison, Patrick, Margulies, Kenneth

“…Abstract only The microtubule contribution to myocyte mechanics has been a controversial topic over the years. Utilizing high-speed, super-resolution imaging,…”
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Direct Observation of Strain Transmission through the Microtubule Network of Cardiomyocytes by Caporizzo, Matthew A., Kao, Brandon, Robison, Patrick, Bogush, Alexey I., Prosser, Benjamin L.

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Acute Reduction of Desmin Intermediate Filaments Alters Myocyte Mechanics and Excitation-Contraction Coupling by Heffler, Julie, Capporizzo, Matthew A., Bogush, Alexey I., Robison, Patrick, Prosser, Benjamin L.

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Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD: E-C Coupling Dysfunction in COPD by Robison, Patrick, Sussan, Thomas E., Chen, Hegang, Biswal, Shyam, Schneider, Martin F., Hernández-Ochoa, Erick O.

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Understanding Viscoelasticity Changes in Single Cells using Variable Indentation-Rate Viscoelastic Analysis by Caporizzo, Matthew A., Robison, Patrick, Bogush, Alexey, Prosser, Benjamin L., Eckmann, David M., Composto, Russell J.

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Atypical NFATc1 Regulation in Cultured Murine Intercostal Muscles by Robison, Patrick, Hernández‐Ochoa, Erick, Schneider, Martin F.

“…Abstract only The transcription factor NFATc1 controls the transformation of skeletal muscle fibers from fast to slow type in response to muscle activity. In…”
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Microtubule Detyrosination Modulates Stretch-Dependent X-ROS Signaling in Heart by Robison, Patrick G., Kerr, Jaclyn P., Bogush, Alexey I., Harki, Daniel A., Ward, Christopher W., Prosser, Benjamin L.

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