Search Results - "Robinson, Stephen R"

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease by Brothers, Holly M, Gosztyla, Maya L, Robinson, Stephen R

“…Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis of Alzheimer's disease (AD), and it is currently the primary…”
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What is the optimal chair stand test protocol for older adults? A systematic review by Mehmet, Hanife, Yang, Angela W. H., Robinson, Stephen R.

“…Purpose: To determine the chair stand test protocol that is most suitable for older adults in clinical settings by reviewing the currently available methods…”
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Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea by Alomri, Ridwan M., Kennedy, Gerard A., Wali, Siraj Omar, Alhejaili, Faris, Robinson, Stephen R.

“…Obstructive sleep apnoea (OSA) is associated with repetitive breathing obstructions during sleep. These episodes of hypoxia and associated arousals from sleep…”
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Twelve protections evolved for the brain, and their roles in extending its functional life by Stone, Jonathan, Mitrofanis, John, Johnstone, Daniel M., Robinson, Stephen R.

“…As human longevity has increased, we have come to understand the ability of the brain to function into advanced age, but also its vulnerability with age,…”
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Quantitative analysis of size and regional distribution of corpora amylacea in the hippocampal formation of obstructive sleep apnoea patients by Xu, Cuicui, Owen, Jessica E., Gislason, Thorarinn, Benediktsdottir, Bryndis, Robinson, Stephen R.

“…Corpora amylacea (CoA) are spherical aggregates of glucose polymers and proteins within the periventricular, perivascular and subpial regions of the cerebral…”
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Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes by Bishop, Glenda M., Dringen, Ralf, Robinson, Stephen R.

“…The release of zinc (Zn) from glutamatergic synapses contributes to the neuropathology of ischemia, traumatic brain injury, and stroke. Astrocytes surround…”
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Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells by Riemer, Jan, Hoepken, Hans Hermann, Czerwinska, Hania, Robinson, Stephen R, Dringen, Ralf

“…The ferrozine-based colorimetric assay described here permits the quantitation of iron in cultured cells in amounts ranging between 0.2 and 30 nmol. Ferrous…”
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Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron by Lane, Darius J R, Robinson, Stephen R, Czerwinska, Hania, Bishop, Glenda M, Lawen, Alfons

“…Astrocytes are central to iron and ascorbate homoeostasis within the brain. Although NTBI (non-transferrin-bound iron) may be a major form of iron imported by…”
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A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse? by Stone, Jonathan, Robinson, Stephen R, Mitrofanis, John, Johnstone, Daniel M

“…This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in…”
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Uptake and Toxicity of Hemin and Iron in Cultured Mouse Astrocytes by Owen, Jessica E., Bishop, Glenda M., Robinson, Stephen R.

“…Hemin is a breakdown product of the blood protein, hemoglobin and is responsible for much of the secondary damage caused following a hemorrhagic stroke. Hemin…”
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The pivotal role of astrocytes in the metabolism of iron in the brain by Dringen, Ralf, Bishop, Glenda M, Koeppe, Maico, Dang, Theresa N, Robinson, Stephen R

“…Iron is essential for the normal functioning of cells but since it is also capable of generating toxic reactive oxygen species, the metabolism of iron is…”
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Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke by Robinson, Stephen R, Dang, Theresa N, Dringen, Ralf, Bishop, Glenda M

“…Hemorrhagic stroke is a common cause of permanent brain damage, with a significant amount of the damage occurring in the weeks following a stroke. This…”
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Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin by Mahzari, Ali, Li, Songpei, Zhou, Xiu, Li, Dongli, Fouda, Sherouk, Alhomrani, Majid, Alzahrani, Wala, Robinson, Stephen R, Ye, Ji-Ming

“…The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and…”
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Accumulation of Non-Transferrin-Bound Iron by Neurons, Astrocytes, and Microglia by Bishop, Glenda M., Dang, Theresa N., Dringen, Ralf, Robinson, Stephen R.

“…Neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and hemorrhagic stroke are associated with increased levels of…”
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Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high-fat-fed mice by Li, Songpei, Zeng, Xiao-Yi, Zhou, Xiu, Wang, Hao, Jo, Eunjung, Robinson, Stephen R., Xu, Aimin, Ye, Ji-Ming

“…The present study investigated the role of dietary cholesterol and fat in the development of nonalcoholic fatty liver disease, a common liver disease in…”
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Recovery of Cognitive Function After Coronary Artery Bypass Graft Operations by Bruce, Kathryn M., BSc(Hons), Yelland, Gregory W., PhD, Smith, Julian A., MBBS, FRACS, Robinson, Stephen R., PhD

“…Background The effect of coronary artery bypass grafting (CABG) operations on cognition was examined after controlling for the operation, emotional state,…”
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The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin by Dang, Theresa N., Bishop, Glenda M., Dringen, Ralf, Robinson, Stephen R.

“…Hemin, which is toxic to brain cells, has been reported to be taken up by cultured astrocytes; however, the mechanism of uptake is currently unknown. The…”
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Alzheimer's Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence by Gosztyla, Maya L, Brothers, Holly M, Robinson, Stephen R

“…The amyloid-β (Aβ) peptide has long been considered to be the driving force behind Alzheimer's disease (AD). However, clinical trials that have successfully…”
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Consequences of redefining Alzheimer's disease in terms of amyloid burden without regard to cognitive decline by Robinson, Stephen, Brothers, Holly, Gosztyla, Maya

“…In addition to its involvement in AD, Aβ is produced by the brain throughout life where it appears to serve several important physiological roles, including…”
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Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity by Liddell, Jeff R., Hoepken, Hans H., Crack, Peter J., Robinson, Stephen R., Dringen, Ralf

“…The enzyme glutathione peroxidase 1 (GPx1) is involved in the cellular detoxification of peroxides. To test for the consequences of GPx deficiency in…”
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