Search Results - "Robinson, Randy R."

Safety and efficacy of daclizumab beta in patients with relapsing multiple sclerosis in a 5-year open-label study (EXTEND): final results following early termination by Kappos, Ludwig, Cohan, Stanley, Arnold, Douglas L., Robinson, Randy R., Holman, Joan, Fam, Sami, Parks, Becky, Xiao, Shan, Castro-Borrero, Wanda

“…Background: EXTEND (NCT01797965), an open-label extension study, evaluated the safety and efficacy of daclizumab beta in participants with relapsing multiple…”
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A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6-Targeting Antibody-Drug Conjugate, in Patients With Small Cell Lung Cancer by Morgensztern, Daniel, Ready, Neal, Johnson, Melissa L, Dowlati, Afshin, Choudhury, Noura, Carbone, David P, Schaefer, Eric, Arnold, Susanne M, Puri, Sonam, Piotrowska, Zofia, Hegde, Aparna, Chiang, Anne C, Iams, Wade, Tolcher, Anthony, Nosaki, Kaname, Kozuki, Toshiyuki, Li, Tianhong, Santana-Davila, Rafael, Akamatsu, Hiroaki, Murakami, Haruyasu, Yokouchi, Hiroshi, Wang, Song, Zha, Jiuhong, Li, Rui, Robinson, Randy R, Hingorani, Pooja, Jeng, Edwin E, Furqan, Muhammad

“…Seizure-related homolog protein 6 (SEZ6) is a novel target expressed in small cell lung cancer (SCLC). ABBV-011, a SEZ6-targeted antibody conjugated to…”
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Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration by Nussenblatt, Robert B, Thompson, Darby J.S, Li, Zhuqing, Peterson, Jan S, Robinson, Randy R, Shames, Richard S, Nagarajan, Sudha, Tang, Meina Tao, Mailman, Michelle, Velez, Gisela, Roy, Chandra, Levy-Clarke, Grace A, Suhler, Eric B, Djalilian, Ali, Sen, Hatice Nida, Al-Khatib, Shadi, Ursea, Roxana, Srivastava, Sunil, Bamji, Allison, Mellow, Susan, Sran, Pushpa, Waldmann, Thomas A, Buggage, Ronald R

“…Therapy for severe uveitis is frequently long-term immunosuppression using systemic corticosteroids and cytotoxic agents, but side effects make long-term…”
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Long-term safety and efficacy of daclizumab beta in relapsing–remitting multiple sclerosis: 6-year results from the SELECTED open-label extension study by Gold, Ralf, Radue, Ernst-Wilhelm, Giovannoni, Gavin, Selmaj, Krzysztof, Havrdova, Eva Kubala, Montalban, Xavier, Stefoski, Dusan, Sprenger, Till, Robinson, Randy R., Fam, Sami, Smith, Jonathan, Chalkias, Spyros, Giannattasio, Giorgio, Lima, Gabriel, Castro-Borrero, Wanda

“…Objective SELECTED, an open-label extension study, evaluated daclizumab beta treatment for up to 6 years in participants with relapsing multiple sclerosis who…”
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Immune Response to Seasonal Influenza Vaccine in Patients with Relapsing-Remitting Multiple Sclerosis Receiving Long-term Daclizumab Beta: A Prospective, Open-Label, Single-Arm Study by Mehta, Lahar, Umans, Kimberly, Ozen, Gulden, Robinson, Randy R, Elkins, Jacob

“…For patients with relapsing-remitting multiple sclerosis (RRMS) undergoing continuous immunomodulatory therapy, understanding whether vaccinations can be…”
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Phase I study of anti-epidermal growth factor receptor antibody-drug conjugate serclutamab talirine: Safety, pharmacokinetics, and antitumor activity in advanced glioblastoma by Carneiro, Benedito A, Papadopoulos, Kyriakos P, Strickler, John H, Lassman, Andrew B, Waqar, Saiama N, Chae, Young Kwang, Patel, Jyoti D, Shacham-Shmueli, Einat, Kelly, Karen, Khasraw, Mustafa, Bestvina, Christine M, Merrell, Ryan, Huang, Kevin, Atluri, Harisha, Ansell, Peter, Li, Rachel, Jin, Janet, Anderson, Mark G, Reilly, Edward B, Morrison-Thiele, Gladys, Patel, Kalpesh, Robinson, Randy R, Aristide, Martha R Neagu, Gan, Hui K

“…Abstract Background Serclutamab talirine (Ser-T, formerly ABBV-321) is an antibody-drug conjugate consisting of an antibody (AM-1-ABT-806) directed against…”
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The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to Zenapax by Ganguly, Bishu, Balasa, Balaji, Efros, Lyubov, Hinton, Paul R, Hartman, Stephen, Thakur, Archana, Xiong, Joanna M, Schmidt, Brian, Robinson, Randy R, Sornasse, Thierry, Vexler, Vladimir, Sheridan, James P

“…The CD25-binding antibody daclizumab high-yield process (DAC HYP) is an interleukin (IL)-2 signal modulating antibody that shares primary amino acid sequence…”
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Daclizumab, an IL-2 modulating antibody for treatment of multiple sclerosis by Sheridan, James P, Robinson, Randy R, Rose, John W

“…Daclizumab is a monoclonal antibody specific for the IL-2R α chain (CD25). Daclizumab has been observed to have multiple mechanisms of action, which may…”
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Escherichia coli Secretion of an Active Chimeric Antibody Fragment by Better, Marc, Chang, C. Paul, Robinson, Randy R., Horwitz, Arnold H.

“…A chimeric mouse-human Fab protein that binds specifically to the human carcinoma cell line C3347 has been expressed and secreted from Escherichia coli. This…”
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Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2 by Hank, J A, Robinson, R R, Surfus, J, Mueller, B M, Reisfeld, R A, Cheung, N K, Sondel, P M

“…Monoclonal antibodies (mAB) with tumor specificity are able to enhance the immunological specificity of interleukin 2 (IL-2)-activated lymphokine activated…”
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Matching-Adjusted Comparison of Daclizumab Beta vs Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis (P1.356) by Newman, Stephen, Ziemssen, Tjalf, Robinson, Randy R., Wu, Fan, Jiang, Xiaoyu, Wakeford, Craig, Giannattasio, Giorgio

“…Abstract only…”
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Safety and Efficacy of Long-Term Treatment With Daclizumab Beta: 6-Year Results From the SELECTED Extension Study (P6.390) by Gold, Ralf, Radue, Ernst-Wilhelm, Giovannoni, Gavin, Selmaj, Krzysztof, Havrdova, Eva, Montalban, Xavier, Stefoski, Dusan, Sprenger, Till, Robinson, Randy R., Smith, Jonathan, Parks, Becky, Giannattasio, Giorgio, Lima, Gabriel

“…Abstract only…”
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Abstract 953: LRRC15 is a novel antigen in sarcoma and the therapeutic target of the antibody-drug conjugate (ADC) ABBV-085 by Ben-Ami, Eytan, Huang, Ying, Gokhale, Prafulla C., Eschle, Benjamin, Durkin, Lisa, Hickson, Jonathan, Sho, Mien, Morgan-Lappe, Susan, Gish, Kurt, Lai, Dominic W., Robinson, Randy R., Hollenbaugh, Diane, Hsi, Eric D., Chao, Debra T., Demetri, George D., Purcell, James W.

“…Background: Leucine rich repeat containing 15 (LRRC15) is a TGFβ-regulated structural protein that is highly expressed on cancer-associated fibroblasts (CAFs)…”
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Immune Response to Seasonal Influenza Vaccine in Patients with Relapsing-Remitting Multiple Sclerosis Receiving Long-term Daclizumab Beta by Mehta, Lahar, Umans, Kimberly, Ozen, Gulden, Robinson, Randy R., Elkins, Jacob

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Corrigendum to “Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration” [J. Autoimmun. 21 (2004) 283–293] by Nussenblatt, Robert B, Thompson, Darby J.S, Li, Zhuqing, Chan, Chi C, Peterson, Jan S, Robinson, Randy R, Shames, Richard S, Nagarajan, Sudha, Tang, Meina Tao, Mailman, Michelle, Velez, Gisela, Roy, Chandra, Levy-Clarke, Grace A, Sujler, Eric B, Djalilian, Ali, Sen, Hatice Nida, Al-Khatib, Shadi, Ursea, Roxana, Srivastava, Sunil, Bamji, Allison, Mellow, Susan, Sran, Pushpa, Waldmann, Thomas A, Buggage, Ronald R

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Secretion of Functional Antibody and Fab Fragment from Yeast Cells by Horwitz, Arnold H., Chang, C. Paul, Better, Marc, Hellstrom, Karl Erik, Robinson, Randy R.

“…We have constructed yeast strains that secrete functional mouse--human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole…”
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Chimeric Mouse-Human IgG1 Antibody that Can Mediate Lysis of Cancer Cells by Liu, Alvin Y., Robinson, Randy R., Hellstrom, Karl Erik, Murray, E. David, Chang, C. Paul, Hellstrom, Ingegerd

“…A chimeric mouse-human antibody has been created that recognizes an antigen found on the surface of cells from many carcinomas. Immunoglobulin constant (C)…”
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The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to Zenapax by Ganguly, Bishu, Balasa, Balaji, Efros, Lyubov, Hinton, Paul R., Hartman, Stephen, Thakur, Archana, Xiong, Joanna M., Schmidt, Brian, Robinson, Randy R., Sornasse, Thierry, Vexler, Vladimir, Sheridan, James P.

“…The CD25-binding antibody daclizumab high-yield process (DAC HYP) is an interleukin (IL)-2 signal modulating antibody that shares primary amino acid sequence…”
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Multiple mRNA species with distinct 3′ termini are transcribed from the β2-microglobulin gene by Parnes, Jane R., Robinson, Randy R., Seidman, J. G.

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Production of anti-erythrocyte antibodies by leukemic and nonleukemic B cells in chronic lymphocytic leukemia patients by Centola, M, Lin, K, Sutton, C, Berenson, J R, Kunkel, L A, Rosen, L, Hahn, B H, Robinson, R R

“…We have assessed the specificity of antibodies from the leukemic B cells of five patients with both chronic lymphocytic leukemia and autoimmune hemolytic…”
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