Search Results - "Robinson, Kristine M."

The selective detection of mitochondrial superoxide by live cell imaging by Beckman, Joseph S, Robinson, Kristine M, Janes, Michael S

“…A general protocol is described to improve the specificity for imaging superoxide formation in live cells via fluorescence microscopy with either hydroethidine…”
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Selective Fluorescent Imaging of Superoxide in vivo Using Ethidium-Based Probes by Robinson, Kristine M., Janes, Michael S., Pehar, Mariana, Monette, Jeffrey S., Ross, Meredith F., Hagen, Tory M., Murphy, Michael P., Beckman, Joseph S.

“…The putative oxidation of hydroethidine (HE) has become a widely used fluorescent assay for the detection of superoxide in cultured cells. By covalently…”
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Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis by Pehar, Mariana, Vargas, Marcelo R, Robinson, Kristine M, Cassina, Patricia, Diaz-Amarilla, Pablo J, Hagen, Tory M, Radi, Rafael, Barbeito, Luis, Beckman, Joseph S

“…Nerve growth factor (NGF) can induce apoptosis by signaling through the p75 neurotrophin receptor (p75(NTR)) in several nerve cell populations. Cultured…”
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Synthesis of peroxynitrite from nitrite and hydrogen peroxide by Robinson, Kristine M, Beckman, Joseph S

“…We report a simple method for the synthesis of peroxynitrite from nitrite and hydrogen peroxide that can generate hundreds of milliliters of 180 mM…”
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A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug by Copenhaver, Philip F, Anekonda, Thimmappa S, Musashe, Derek, Robinson, Kristine M, Ramaker, Jenna M, Swanson, Tracy L, Wadsworth, Teri L, Kretzschmar, Doris, Woltjer, Randall L, Quinn, Joseph F

“…A growing body of evidence supports the 'calcium hypothesis' of Alzheimer's disease (AD), which postulates that a variety of insults might disrupt the…”
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Prevention of Peroxynitrite-induced Apoptosis of Motor Neurons and PC12 Cells by Tyrosine-containing Peptides by Ye, Yaozu, Quijano, Celia, Robinson, Kristine M., Ricart, Karina C., Strayer, Amy L., Garner, Mary Anne, Shacka, John J., Kirk, Marion, Barnes, Stephen, Accavitti-Loper, Mary Ann, Radi, Rafael, Beckman, Joseph S., Estévez, Alvaro G.

“…Although peroxynitrite stimulates apoptosis in many cell types, whether peroxynitrite acts directly as an oxidant or the induction of apoptosis is because of…”
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Triuret: a novel product of peroxynitrite-mediated oxidation of urate by Robinson, Kristine M, Morré, Jeffrey T, Beckman, Joseph S

“…Urate is an efficient antioxidant and has recently emerged as a competitive inhibitor of tyrosine nitration by peroxynitrite. In vivo and in vitro studies…”
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Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants by Cassina, Patricia, Cassina, Adriana, Pehar, Mariana, Castellanos, Raquel, Gandelman, Mandi, de Leon, Andres, Robinson, Kristine M, Mason, Ronald P, Beckman, Joseph S, Barbeito, Luis, Radi, Rafael

“…Mitochondrial dysfunction and oxidative stress contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Recent reports indicate that…”
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Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons by Pehar, Mariana, Vargas, Marcelo R., Robinson, Kristine M., Cassina, Patricia, England, Patrick, Beckman, Joseph S., Alzari, Pedro M., Barbeito, Luis

“…Nerve growth factor (NGF) overexpression and increased production of peroxynitrite occur in several neurodegenerative diseases. We investigated whether NGF…”
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MR Imaging of Inflammation during Myelin-Specific T Cell-Mediated Autoimmune Attack in the EAE Mouse Spinal Cord by Robinson, Kristine M., Njus, Jeffrey M., Phillips, Daniel A., Proctor, Thomas M., Rooney, William D., Jones, Richard E.

“…Purpose The purpose of this study is to detect myelin-specific T cells, key pathological mediators in early multiple sclerosis, and the corresponding animal…”
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Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimera by Robinson, Kristine M, Markwardt, Sheila, Kitzerow, Nick, Moes, Nicole, Estrada, Mary, Jones, Richard E

“…Abstract Xenotransplantation of rat bone marrow cells (BMC) into immunodeficient (SCID) mice generates chimeric mice susceptible to paralytic autoimmune CNS…”
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Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimeras by Robinson, Kristine M, Markwardt, Sheila, Kitzerow, Nick, Moes, Nicole, Estrada, Mary, Jones, Richard E

“…Xenotransplantation of rat bone marrow cells (BMC) into immunodeficient (SCID) mice generates chimeric mice susceptible to paralytic autoimmune CNS…”
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Mitochondrial Dysfunction in SOD1 G93A -Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants by Cassina, Patricia, Cassina, Adriana, Pehar, Mariana, Castellanos, Raquel, Gandelman, Mandi, de León, Andrés, Robinson, Kristine M., Mason, Ronald P., Beckman, Joseph S., Barbeito, Luis, Radi, Rafael

“…Mitochondrial dysfunction and oxidative stress contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Recent reports indicate that…”
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Mitochondrial Dysfunction in SOD1 super(G93A)-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants by Cassina, Patricia, Cassina, Adriana, Pehar, Mariana, Castellanos, Raquel, Gandelman, Mandi, de Leon, Andres, Robinson, Kristine M, Mason, Ronald P, Beckman, Joseph S, Barbeito, Luis, Radi, Rafael

“…Mitochondrial dysfunction and oxidative stress contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Recent reports indicate that…”
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The detection of superoxide and implications for amyotrophic lateral sclerosis by Robinson, Kristine M

“…Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the…”
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Trends in Midwifery Use in Manitoba by Thiessen, Kellie, RM, RN, PhD, Heaman, Maureen, RN, PhD, Mignone, Javier, PhD, Martens, Patricia, PhD, Robinson, Kristine, BScN, RM, MSc

“…Abstract Objective To describe the trends in numbers of midwives and midwifery-attended births and the characteristics of women who used midwifery health care…”
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