Search Results - "Robinson, Jake A."

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice by Dash, Prasanta K., Kaminski, Rafal, Bella, Ramona, Su, Hang, Mathews, Saumi, Ahooyi, Taha M., Chen, Chen, Mancuso, Pietro, Sariyer, Rahsan, Ferrante, Pasquale, Donadoni, Martina, Robinson, Jake A., Sillman, Brady, Lin, Zhiyi, Hilaire, James R., Banoub, Mary, Elango, Monalisha, Gautam, Nagsen, Mosley, R. Lee, Poluektova, Larisa Y., McMillan, JoEllyn, Bade, Aditya N., Gorantla, Santhi, Sariyer, Ilker K., Burdo, Tricia H., Young, Won-Bin, Amini, Shohreh, Gordon, Jennifer, Jacobson, Jeffrey M., Edagwa, Benson, Khalili, Kamel, Gendelman, Howard E.

“…Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective…”
Get full text

CRISPR based editing of SIV proviral DNA in ART treated non-human primates by Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel

“…Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a…”
Get full text

HIV-Associated Neurocognitive Impairment in the Modern ART Era: Are We Close to Discovering Reliable Biomarkers in the Setting of Virological Suppression? by Bandera, Alessandra, Taramasso, Lucia, Bozzi, Giorgio, Muscatello, Antonio, Robinson, Jake A, Burdo, Tricia H, Gori, Andrea

“…The prevalence of the most severe forms of HIV-associated neurocognitive disorders (HAND) is decreasing due to worldwide availability and high efficacy of…”
Get full text

Characterization of Nef expression in different brain regions of SIV-infected macaques by Yarandi, Shadan S, Robinson, Jake A, Vakili, Sarah, Donadoni, Martina, Burdo, Tricia H, Sariyer, Ilker K

“…HIV-associated CNS dysfunction is a significant problem among people with HIV (PWH), who now live longer due to viral suppression from combined anti-retroviral…”
Get full text

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques by Podgorski, Rachel M, Robinson, Jake A, Smith, Mandy D, Mallick, Suvadip, Zhao, Huaqing, Veazey, Ronald S, Kolson, Dennis L, Bar, Katharine J, Burdo, Tricia H

“…A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV…”
Get full text

Antiretroviral Therapy Ameliorates Simian Immunodeficiency Virus–Associated Myocardial Inflammation by Dampening Interferon Signaling and Pathogen Response in the Heart by Robinson, Jake A, Niu, Meng, Fox, Howard S, Burdo, Tricia H

“…Abstract People with human immunodeficiency virus have an increased risk of developing cardiovascular disease. RNA-Seq was performed on hearts from simian…”
Get full text

Neuroinflammation in the Dorsal Root Ganglia and Dorsal Horn Contributes to Persistence of Nociceptor Sensitization in SIV-Infected Antiretroviral Therapy-Treated Macaques by Warfield, Rebecca, Robinson, Jake A, Podgorski, Rachel M, Miller, Andrew D, Burdo, Tricia H

“…Despite the development of antiretroviral therapy (ART), HIV-associated distal sensory polyneuropathy remains prevalent. Using SIV-infected rhesus macaques,…”
Get full text

Increased Peripheral Inflammation Is Associated With Structural Brain Changes and Reduced Blood Flow in People With Virologically Controlled HIV by Burdo, Tricia H, Robinson, Jake A, Cooley, Sarah, Smith, Mandy D, Flynn, Jacqueline, Petersen, Kalen J, Nelson, Brittany, Westerhaus, Elizabeth, Wisch, Julie, Ances, Beau M

“…Abstract Background While antiretroviral therapy (ART) has improved outcomes for people with HIV (PWH), brain dysfunction is still evident. Immune activation…”
Get full text

Osteopontin Is an Integral Mediator of Cardiac Interstitial Fibrosis in Models of Human Immunodeficiency Virus Infection by Robinson, Jake A, Mahmud, Farina J, Greif, Elizabeth, Toribio, Mabel, Zanni, Markella V, Brown, Amanda M, Burdo, Tricia H

“…Abstract Background People with human immunodeficiency virus (HIV) have heightened incidence/risk of diastolic dysfunction and heart failure. Women with HIV…”
Get full text

Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons With Human Immunodeficiency Virus by Fourman, Lindsay T, Saylor, Charles F, Cheru, Lediya, Fitch, Kathleen, Looby, Sara, Keller, Kiana, Robinson, Jake A, Hoffmann, Udo, Lu, Michael T, Burdo, Tricia, Lo, Janet

“…Abstract Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons…”
Get full text

SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity by Shekarabi, Masoud, Robinson, Jake A, Smith, Mandy D, Burdo, Tricia H

“…Although the reduction of viral loads in people with HIV undergoing combination antiretroviral therapy has mitigated AIDS-related symptoms, the prevalence of…”
Get full text

Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort by Kearns, Alison C, Liu, Fengming, Dai, Shen, Robinson, Jake A, Kiernan, Elizabeth, Tesfaye Cheru, Lediya, Peng, Xiao, Gordon, Jennifer, Morgello, Susan, Abuova, Aishazhan, Lo, Janet, Zanni, Markella V, Grinspoon, Steven K, Burdo, Tricia H, Qin (Chinese Character), Xuebin

“…OBJECTIVE:Atherosclerotic cardiovascular disease (ASCVD) is an increasing cause of morbidity and mortality in people with HIV since the introduction of…”
Get full text

Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV by Robinson, Jake A., Toribio, Mabel, Quinaglia, Thiago, Awadalla, Magid, Talathi, Ria, Durbin, Claudia G., Alhallak, Iad, Alagpulinsa, David A., Fourman, Lindsay T., Suero-Abreu, Giselle Alexandra, Nelson, Michael D., Stanley, Takara L., Longenecker, Christopher T., Szczepaniak, Lidia S., Jerosch-Herold, Michael, Neilan, Tomas G., Zanni, Markella V., Burdo, Tricia H.

“…Women with HIV (WWH) have heightened heart failure risk. Plasma OPN (osteopontin) is a powerful predictor of heart failure outcomes in the general population…”
Get full text

Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine by Sariyer, Ilker Kudret, Gordon, Jennifer, Burdo, Tricia H., Wollebo, Hassen S., Gianti, Eleonora, Donadoni, Martina, Bellizzi, Anna, Cicalese, Stephanie, Loomis, Regina, Robinson, Jake A., Carnevale, Vincenzo, Steiner, Joseph, Ozdener, Mehmet H., Miller, Andrew D., Amini, Shohreh, Klein, Michael L., Khalili, Kamel

“…Zika virus (ZIKV) infection is associated with microcephaly in neonates and Guillain-Barré syndrome in adults. ZIKV produces a class of nonstructural (NS)…”
Get full text

Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection by Robinson, Jake A., Guenthner, Guy, Warfield, Rebecca, Kublin, Jessica R., Smith, Mandy D., Shekarabi, Masoud, Miller, Andrew D., Burdo, Tricia H.

“…HIV-associated sensory neuropathy is a common neurologic comorbidity of HIV infection and prevails in the post–antiretroviral therapy (ART) era. HIV infection…”
Get full text

Caspase-1-associated immune activation in an accelerated SIV-infected rhesus macaque model by Kearns, Alison C., Robinson, Jake A., Shekarabi, Masoud, Liu, Fengming, Qin, Xuebin, Burdo, Tricia H.

“…In the antiretroviral therapy (ART) era, chronic HIV infection is primarily associated with chronic inflammation driving comorbidities such as cardiovascular…”
Get full text

Pro-Inflammatory Interleukin-18 is Associated with Hepatic Steatosis and Elevated Liver Enzymes in People with HIV Monoinfection by Sim, Jae H, Sherman, Julia B, Stanley, Takara L, Corey, Kathleen E, Fitch, Kathleen V, Looby, Sara E, Robinson, Jake A, Lu, Michael T, Burdo, Tricia H, Lo, Janet

“…People with HIV (PWH) are at an increased risk of developing nonalcoholic fatty liver disease (NAFLD). Interleukin (IL)-18 is regulated by inflammasomes in…”
Get more information

α4-Integrin Antibody Treatment Blocks Monocyte/Macrophage Traffic to, Vascular Cell Adhesion Molecule-1 Expression in, and Pathology of the Dorsal Root Ganglia in an SIV Macaque Model of HIV-Peripheral Neuropathy by Lakritz, Jessica R, Thibault, Derek, Robinson, Jake A, Campbell, Jennifer, Miller, Andrew D, Williams, Kenneth, Burdo, Tricia H

“…Traffic of activated monocytes into the dorsal root ganglia (DRG) is critical for pathology in HIV peripheral neuropathy. We have shown that accumulation of…”
Get full text

Acute hyperinsulinemia effects on systemic markers of immune activation in HIV by O'Malley, Timothy K, Burdo, Tricia H, Robinson, Jake A, Fitch, Kathleen V, Grinspoon, Steven K, Srinivasa, Suman

“…: The well treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on…”
Get full text

Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins by Lakritz, Jessica R, Robinson, Jake A, Polydefkis, Michael J, Miller, Andrew D, Burdo, Tricia H

“…Peripheral neuropathy (PN) continues to be a major complication of human immunodeficiency virus (HIV) infection despite successful anti-retroviral therapy…”
Get full text