Search Results - "Robinson, Gerard P."

Skeletal Muscle Interleukin-6 Contributes to the Innate Immune Response in Septic Mice by Laitano, Orlando, Robinson, Gerard P., Garcia, Christian K., Mattingly, Alex J., Sheikh, Laila H., Murray, Kevin O., Iwaniec, John D., Alzahrani, Jamal, Morse, Deborah, Hidalgo, Juan, Clanton, Thomas L.

“…ABSTRACTInterleukin-6 (IL-6) is a major cytokine released by skeletal muscle. Although IL-6 plays complex but well-known roles in host defense, the specific…”
Get full text

Skeletal muscle fibers play a functional role in host defense during sepsis in mice by Laitano, Orlando, Robinson, Gerard P., Murray, Kevin O., Garcia, Christian K., Mattingly, Alex J., Morse, Deborah, King, Michelle A., Iwaniec, John D., Alzahrani, Jamal M., Clanton, Thomas L.

“…Skeletal muscles secrete a wide variety of immunologically active cytokines, but the functional significance of this response to in vivo innate immunity is not…”
Get full text

Delayed metabolic disturbances in the myocardium after exertional heat stroke: contrasting effects of exertion and thermal load by Garcia, Christian K, Gambino, Bryce J, Robinson, Gerard P, Rua, Michael T, Alzahrani, Jamal M, Clanton, Thomas L

“…Epidemiological studies report higher risks of cardiovascular disease in humans exposed to heat stroke earlier in life. Previously, we explored mechanistic…”
Get full text

Exertional heat stroke leads to concurrent long‐term epigenetic memory, immunosuppression and altered heat shock response in female mice by Murray, Kevin O., Brant, Jason O., Iwaniec, John D., Sheikh, Laila H., Carvalho, Lucas, Garcia, Christian K., Robinson, Gerard P., Alzahrani, Jamal M., Riva, Alberto, Laitano, Orlando, Kladde, Michael P., Clanton, Thomas L.

“…Key points Exposure to exertional heat stroke (EHS) has been linked to increased long‐term decrements of health. Epigenetic reprogramming is involved in the…”
Get full text

Lipopolysaccharide-Induced Cytokine Secretion from In Vitro Mouse Slow and Fast Limb Muscle by Mattingly, Alex J., Laitano, Orlando, Garcia, Christian K., Robinson, Gerard P., Clanton, Thomas L.

“…Skeletal muscles play important roles in innate immunity. However, in vitro, their sensitivity to LPS is low. In other tissues, LPS sensing is facilitated by…”
Get full text

Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice by Laitano, Orlando, Garcia, Christian K., Mattingly, Alex J., Robinson, Gerard P., Murray, Kevin O., King, Michelle A., Ingram, Brian, Ramamoorthy, Sivapriya, Leon, Lisa R., Clanton, Thomas L.

“…Key points Exposure to exertional heat stroke (EHS) is associated with increased risk of long‐term cardiovascular disorders in humans. We demonstrate that in…”
Get full text

Sex-dependent responses to exertional heat stroke in mice by Garcia, Christian K, Mattingly, Alex J, Robinson, Gerard P, Laitano, Orlando, King, Michelle A, Dineen, Shauna M, Leon, Lisa R, Clanton, Thomas L

“…With increasing participation of females in endurance athletics and active military service, it is important to determine if there are inherent sex-dependent…”
Get full text

Acute phase response to exertional heat stroke in mice by Iwaniec, John, Robinson, Gerard P., Garcia, Christian K., Murray, Kevin O., Carvalho, Lucas, Clanton, Thomas L., Laitano, Orlando

“…New Findings What is the central question of this study? Exertional heat stroke is accompanied by a marked inflammatory response. In this study, we explored…”
Get full text

The impact of castration on physiological responses to exertional heat stroke in mice by Garcia, Christian K, Robinson, Gerard P, Gambino, Bryce J, Rua, Michael T, Laitano, Orlando, Clanton, Thomas L

“…Introduction The capability of male mice to exercise in hot environments without succumbing to exertional heat stroke (EHS) is markedly blunted compared to…”
Get full text

A New Model of Exertional Heat Stroke in Male Mice Reveals Sustained Metabolic Dysfunction in the Myocardium by Gambino, Bryce J., Garcia, Christian K., Rua, Michael T., Robinson, Gerard P., Delgado, Cristina D., Alzahrani, Jamal M., Cusack, Kevin J., Clanton, Thomas L.

“…Exertional heat stroke (EHS) is a life threating condition that has grown in prevalence with rising global temperatures. Development and use of new preclinical…”
Get full text

Effects of Ibuprofen during Exertional Heat Stroke in Mice by GARCIA, CHRISTIAN K., SHEIKH, LAILA H., IWANIEC, JOHN D., ROBINSON, GERARD P., BERLET, REED A., MATTINGLY, ALEX J., MURRAY, KEVIN O., LAITANO, ORLANDO, CLANTON, THOMAS L.

“…Intestinal injury is one of the most prominent features of organ damage in exertional heat stroke (EHS). However, whether damage to the intestine in this…”
Get full text

Xiphoid Surface Temperature Predicts Mortality in a Murine Model of Septic Shock by Laitano, Orlando, Van Steenbergen, David, Mattingly, Alex J, Garcia, Christian K, Robinson, Gerard P, Murray, Kevin O, Clanton, Thomas L, Nunamaker, Elizabeth A

“…ABSTRACTSepsis continues to be a major challenge for modern medicine. Several preclinical models were developed to study sepsis and each has strengths and…”
Get full text

Lipopolysaccharide-Induced Cytokine Secretion From in Vitro Mouse Slow and Fast Limb Muscle by Mattingly, Alex J., Laitano, Orlando, Garcia, Christian K., Robinson, Gerard P., Clanton, Thomas L.

Get full text

After exertional heat stroke, is cooling to <40°C sufficient? Revisiting an established protocol in a mouse model by Alzahrani, Jamal Mohammed, Garcia, Christian K., Murray, Kevin O., Robinson, Gerard P., Sheikh, Laila A., Laitano, Orlando, Clanton, Thomas L.

“…Abstract only…”
Get full text

Physical Factors Related To Heat Exchange In Male And Female Mice During Exertional Heat Stroke: 533 May 30 2: 15 PM - 2: 30 PM by Garcia, Christian K., Mattingly, Alex, Robinson, Gerard P., Laitano, Orlando, Clanton, Thomas L.

Get full text

Deficits in Motor Function After Repeated Exertional Heat Stroke Exposure in Female Mice by Alzahrani, Jamal Mohammed, Murray, Kevin O, Sheikh, Laila, Garcia, Christian K, Robinson, Gerard P, Laitano, Orlando, Clanton, Thomas L

“…Exertional Heat Stroke (EHS) is a life‐threatening illness that can result in a number of negative health outcomes. Once exposed to EHS, patients are…”
Get full text

Stress‐Induced Cardiomyopathy Following Exertional Heat Stroke in Mice by Laitano, Orlando, Garcia, Christian K., Mattingly, Alex J., Robinson, Gerard P., Murray, Kevin O., King, Michelle, Ingram, Brian, Ramamoorthy, Sivapriya, Leon, Lisa R., Clanton, Thomas L.

“…Abstract only…”
Get full text

Suppressed inflammatory phenotype following exertional heat stroke in mice: an epigenetic link? by Murray, Kevin O., Iwaniec, John, Brant, Jason, de Carvalho, Lucas, Robinson, Gerard P, Garcia, Christian K, Alzahrani, Jamal, Laitano, Orlando, Kladde, Michael P., Clanton, Thomas L.

“…Abstract only…”
Get full text

Myocardial oxidative stress and inflammation emerges during recovery from exertional heat stroke in female but not male mice by Garcia, Christian K., Robinson, Gerard P., Mattingly, Alex J., Iwaniec, John D., De Carvalho, Lucas, Alzahrani, Jamal, Murray, Kevin O., Laitano, Orlando, Clanton, Thomas L.

“…Abstract only…”
Get full text

Hyperthermia and extracellular hyperosmolality affect sarcolemmal damage and protein oxidation in mammalian skeletal muscle in vitro by Laitano, Orlando, Mattingly, Alex J., Robinson, Gerard P., Garcia, Christian K., Clanton, Thomas L.

“…Abstract only In the US Armed Services, the incidence of rhabdomyolysis is 5–7 fold higher in peak summer months, suggesting that muscle membrane injury could…”
Get full text