Search Results - "Robinson, Emma"

Power failure: why small sample size undermines the reliability of neuroscience by Button, Katherine S., Ioannidis, John P. A., Mokrysz, Claire, Nosek, Brian A., Flint, Jonathan, Robinson, Emma S. J., Munafò, Marcus R.

“…Key Points Low statistical power undermines the purpose of scientific research; it reduces the chance of detecting a true effect. Perhaps less intuitively, low…”
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A survey on active learning and human-in-the-loop deep learning for medical image analysis by Budd, Samuel, Robinson, Emma C., Kainz, Bernhard

“…•Active learning: to choose the best data to annotate for optimal model performance.•Interpretation + Refinement: feedback for a prediction, meaningful ways to…”
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Translational new approaches for investigating mood disorders in rodents and what they may reveal about the underlying neurobiology of major depressive disorder by Robinson, Emma S. J.

“…Mood disorders represent one of society's most costly and challenging health burdens. The drug treatments used today were initially discovered serendipitously…”
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Human brain mapping: A systematic comparison of parcellation methods for the human cerebral cortex by Arslan, Salim, Ktena, Sofia Ira, Makropoulos, Antonios, Robinson, Emma C., Rueckert, Daniel, Parisot, Sarah

“…The macro-connectome elucidates the pathways through which brain regions are structurally connected or functionally coupled to perform a specific cognitive…”
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Evidence that neuropsychological deficits following early life adversity may underlie vulnerability to depression by Stuart, Sarah A, Hinchcliffe, Justyna K, Robinson, Emma S J

“…Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the underlying mechanisms are not well understood. Clinical studies…”
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Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats by Bari, Andrea, Eagle, Dawn M., Mar, Adam C., Robinson, Emma S. J., Robbins, Trevor W.

“…Rationale The stop-signal paradigm measures the ability to stop a motor response after its execution has been initiated. Impairments in inhibiting…”
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Rat 50 kHz calls reflect graded tickling-induced positive emotion by Hinchcliffe, Justyna K., Mendl, Michael, Robinson, Emma S.J.

“…Positive animal emotion (affect) is a key component of good animal welfare [1] and plays an important role in stress-coping and resilience [2]. Methods for…”
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Pharmacological characterisation of the effort for reward task as a measure of motivation for reward in male mice by Marangoni, Caterina, Tam, Melissa, Robinson, Emma S. J., Jackson, Megan G.

“…Rationale Motivational deficits are a common symptom shared across multiple psychiatric and neurodegenerative disorders. Effort-based decision-making tasks are…”
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Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task by Anderson, Michael H., Munafò, Marcus R., Robinson, Emma S. J.

“…Rationale Affective states are known to influence behaviour in humans resulting in cognitive affective biases, which may play an important role in the…”
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Reducing the stress of drug administration: implications for the 3Rs by Stuart, Sarah A., Robinson, Emma S.J.

“…Restraint in animals is known to cause stress but is used during almost all scientific procedures in rodents, representing a major welfare and scientific…”
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Blockade of noradrenaline re-uptake sites improves accuracy and impulse control in rats performing a five-choice serial reaction time tasks by Robinson, Emma S. J.

“…Rationale Atomoxetine, reboxetine and methylphenidate all act at the noradrenaline transporter (NAT) and atomoxetine and methylphenidate are licensed for the…”
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Differential roles for cortical versus sub-cortical noradrenaline and modulation of impulsivity in the rat by Benn, Abigail, Robinson, Emma S. J.

“…Rationale Atomoxetine is a noradrenaline re-uptake inhibitor licensed for the treatment of adult and childhood attention deficit hyperactivity disorder…”
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Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement by Dalley, Jeffrey W., Fryer, Tim D., Brichard, Laurent, Robinson, Emma S. J., Theobald, David E. H., Lääne, Kristjan, Peña, Yolanda, Murphy, Emily R., Shah, Yasmene, Probst, Katrin, Abakumova, Irina, Aigbirhio, Franklin I., Richards, Hugh K., Hong, Young, Baron, Jean-Claude, Everitt, Barry J., Robbins, Trevor W.

“…Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a…”
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Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task by Benn, Abigail, Robinson, Emma S J

“…The 5-choice serial reaction time task (5CSRTT) has been widely used to study attention and impulse control in rodents. In order to mimic cognitive impairments…”
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Functional connectomics from resting-state fMRI by Smith, Stephen M, Vidaurre, Diego, Beckmann, Christian F, Glasser, Matthew F, Jenkinson, Mark, Miller, Karla L, Nichols, Thomas E, Robinson, Emma C, Salimi-Khorshidi, Gholamreza, Woolrich, Mark W, Barch, Deanna M, Uğurbil, Kamil, Van Essen, David C

“…Highlights • Spontaneous fluctuations in brain activity reflect functional brain networks. • We review rfMRI for mapping the functional connectome. • We review…”
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Development of a novel rodent rapid serial visual presentation task reveals dissociable effects of stimulant versus nonstimulant treatments on attentional processes by Benn, Abigail, Robinson, Emma S. J.

“…The rapid serial visual presentation (RSVP) task and continuous performance tasks (CPT) are used to assess attentional impairments in patients with psychiatric…”
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Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure by Nagaraju, Chandan K., Robinson, Emma L., Abdesselem, Mouna, Trenson, Sander, Dries, Eef, Gilbert, Guillaume, Janssens, Stefan, Van Cleemput, Johan, Rega, Filip, Meyns, Bart, Roderick, H. Llewelyn, Driesen, Ronald B., Sipido, Karin R.

“…Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of…”
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Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats by Hinchcliffe, Justyna K., Stuart, Sarah A., Mendl, Michael, Robinson, Emma S. J.

“…Rationale Affective biases are hypothesised to contribute to the cause and treatment of mood disorders. We have previously found that affective biases,…”
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Regulatory RNAs in Heart Failure by Gomes, Clarissa Pedrosa da Costa, Schroen, Blanche, Kuster, Gabriela M., Robinson, Emma L., Ford, Kerrie, Squire, Iain B., Heymans, Stephane, Martelli, Fabio, Emanueli, Costanza, Devaux, Yvan

“…Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a leading cause of mortality and disability despite significant efforts to…”
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Diffusion Modelling Reveals the Decision Making Processes Underlying Negative Judgement Bias in Rats by Hales, Claire A, Robinson, Emma S J, Houghton, Conor J

“…Human decision making is modified by emotional state. Rodents exhibit similar biases during interpretation of ambiguous cues that can be altered by affective…”
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