Search Results - "Robinson, ED"

Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration by Lunniss, Christopher J., Cooper, Anthony W.J., Eldred, Colin D., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Preston, Alex G.S., Ranshaw, Lisa E., Redgrave, Alison J., Ed Robinson, J., Shipley, Tracy J., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

“…A series of quinoline-3-carboxamides has been identified as potent inhibitors of PDE4. The SAR has been explored and these studies have highlighted compounds…”
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ACTINN: automated identification of cell types in single cell RNA sequencing by Ma, Feiyang, Pellegrini, Matteo, Robinson, ed., Mark

“…Abstract Motivation Cell type identification is one of the major goals in single cell RNA sequencing (scRNA-seq). Current methods for assigning cell types…”
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A Consistent and Integrated High-Resolution Stratigraphic Framework for the Sokor Alternances in the R3 East Area, Agadem Basin, Niger by Rojas, Temistocles, Bastante, Raul, Robinson, Ed, Wright, Tim, Ribeiro, Christophe

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The design of potent, non-peptidic inhibitors of hepatitis C protease by Andrews, David M., Chaignot, Helene M., Coomber, Barry A., Dowle, Mike D., Lucy Hind, S., Johnson, Martin R., Jones, Paul S., Mills, Gail, Patikis, Angela, Pateman, Tony J., Ed Robinson, J., Slater, Martin J., Trivedi, Naimisha

“…The pyrrolidine-5,5- trans-lactam template was used to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease displaying potent…”
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Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease by Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole

“…Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties,…”
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efam: an e xpanded, metaproteome-supported HMM profile database of viral protein fam ilies by Zayed, Ahmed A., Lücking, Dominik, Mohssen, Mohamed, Cronin, Dylan, Bolduc, Ben, Gregory, Ann C., Hargreaves, Katherine R., Piehowski, Paul D., White III, Richard A., Huang, Eric L., Adkins, Joshua N., Roux, Simon, Moraru, Cristina, Sullivan, Matthew B., Robinson, ed., Peter

“…Abstract Motivation Viruses infect, reprogram and kill microbes, leading to profound ecosystem consequences, from elemental cycling in oceans and soils to…”
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efam: an e xpanded, metaproteome-supported HMM profile database of viral protein fam ilies by Zayed, Ahmed A, Lücking, Dominik, Mohssen, Mohamed, Cronin, Dylan, Bolduc, Ben, Gregory, Ann C, Hargreaves, Katherine R, Piehowski, Paul D, White III, Richard A, Huang, Eric L, Adkins, Joshua N, Roux, Simon, Moraru, Cristina, Sullivan, Matthew B

“…Abstract Motivation Viruses infect, reprogram and kill microbes, leading to profound ecosystem consequences, from elemental cycling in oceans and soils to…”
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7kW GaN W-band transmitter by Brown, Ken, Brown, Andrew, Feenstra, Travis, Gritters, Darin, O'Connor, Shane, Sotelo, Mike, Kolias, Nick, Hwang, K. C., Kotce, Jeffrey, Robinson, Ed

“…Recent advances in high power millimeter wave (mmW) Gallium Nitride (GaN) technology has enabled the development of a high power solid state W-band transmitter…”
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Culture, Style and the Educative Process: Making Schools Work for Racially Diverse Students. Second Edition by Shade, Barbara J. Robinson, Ed

“…Many students of color are not performing to their maximum potential within the current school setting, and examinations of this problem suggest significant…”
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Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease by Andrews, David M, Carey, Seb J, Chaignot, Helene, Coomber, Barry A, Gray, Norman M, Hind, S. Lucy, Jones, Paul S, Mills, Gail, Robinson, J. Ed, Slater, Martin J

“…In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of…”
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Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease by Andrews, David M, Barnes, Michael C, Dowle, Mike D, Hind, S. Lucy, Johnson, Martin R, Jones, Paul S, Mills, Gail, Patikis, Angela, Pateman, Tony J, Redfern, Tracy J, Robinson, J. Ed, Slater, Martin J, Trivedi, Naimisha

“…In this, the second of two Letters, the optimization of the pyrrolidine-5,5-trans-lactam template (exemplified by 1a) as a mechanism-based inhibitor of…”
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FUN-PROSE: A deep learning approach to predict condition-specific gene expression in fungi by Nambiar, Ananthan, Dubinkina, Veronika, Liu, Simon, Maslov, Sergei

“…mRNA levels of all genes in a genome is a critical piece of information defining the overall state of the cell in a given environmental condition. Being able…”
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First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease by Linton, Steven D, Aja, Teresa, Armstrong, Robert A, Bai, Xu, Chen, Long-Shiuh, Chen, Ning, Ching, Brett, Contreras, Patricia, Diaz, Jose-Luis, Fisher, Craig D, Fritz, Lawrence C, Gladstone, Patricia, Groessl, Todd, Gu, Xin, Herrmann, Julia, Hirakawa, Brad P, Hoglen, Niel C, Jahangiri, Kathy G, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph, McQuiston, Jeff, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Sayers, Robert O, Sebring, Kristen, Spada, Alfred P, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Valentino, Karen L, Weeks, Suzanne, Winn, David, Wu, Joe C, Yeo, Pauline, Zhang, Cheng-zhi

“…A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure−activity…”
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Pyrrolidine-5,5-trans-lactams. 2. The Use of X-ray Crystal Structure Data in the Optimization of P3 and P4 Substituents by Andrews, David M, Chaignot, Helene, Coomber, Barry A, Good, Andrew C, Hind, S. Lucy, Johnson, Martin R, Jones, Paul S, Mills, Gail, Robinson, J. Ed, Skarzynski, Tadeusz, Slater, Martin J, Somers, Donald O'N

“…In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal…”
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Survey of Patient and Family Preparation and Satisfaction with the Oral Food Challenge (OFC) Experience by Robinson, E.D, Noone, S, Walsh, S, Chao, J, Nowak-Wegrzyn, A

“…Parents/guardians of 100 food allergic children presenting for OFC were administered a survey that contained 15 questions (yes/no, write in, multiple choice…”
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It Takes an Ecosystem: Understanding the People, Places, and Possibilities of Learning and Development across Settings. Current Issues in Out-of-School Time by Akiva, Thomas, Ed, Robinson, Kimberly H., Ed

“…"It Takes an Ecosystem" explores the idea and potential of the Allied Youth Fields--an aspirational term that suggests increased connection across the multiple…”
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Recognition of Clinical Tolerance to Baked Milk Products in Milk-Allergic Children by Bloom, K.A, Nowak-Wegrzyn, A, Walsh, S.M, Robinson, E.D, Mishoe, M, Sampson, H.A

“…SPTs and milk-specific IgE levels may be useful in distinguishing children who have persistent milk or who have "outgrown" their milk allergy, but do not…”
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A mild method for the synthesis of furans. Application to 2,5-bridged furano macrocyclic compounds by Marshall, James A, Robinson, Edward D

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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke by Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.

“…Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies…”
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Synthesis of N-Alkyl Substituted Indolocarbazoles as Potent Inhibitors of Human Cytomegalovirus Replication by Slater, Martin J, Baxter, Robert, Bonser, Robert W, Cockerill, Stuart, Gohil, Kam, Parry, Nigel, Robinson, Ed, Randall, Roger, Yeates, Clive, Snowden, Wendy, Walters, Adeline

“…The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole…”
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