Search Results - "Robinson, C. F."

Genetic Regulation of Pituitary Gland Development in Human and Mouse by Kelberman, Daniel, Rizzoti, Karine, Lovell-Badge, Robin, Robinson, Iain C. A. F, Dattani, Mehul T

“…Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors…”
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Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor by Thompson, Nichola M, Gill, Dave A. S, Davies, Rhos, Loveridge, Nigel, Houston, Pamela A, Robinson, Iain C. A. F, Wells, Timothy

“…Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH. The function of the major circulating isoform of ghrelin,…”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus by Osterstock, Guillaume, Escobar, Pauline, Mitutsova, Violeta, Gouty-Colomer, Laurie-Anne, Fontanaud, Pierre, Molino, François, Fehrentz, Jean-Alain, Carmignac, Danielle, Martinez, Jean, Guerineau, Nathalie C, Robinson, Iain C A F, Mollard, Patrice, Méry, Pierre-François

“…Ghrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains…”
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Regulation of Rapid Signal Transducer and Activator of Transcription-5 Phosphorylation in the Resting Cells of the Growth Plate and in the Liver by Growth Hormone and Feeding by Gevers, Evelien F, Hannah, Matthew J, Waters, Michael J, Robinson, Iain C. A. F

“…GH has physiological functions in many tissues, but the cellular targets for direct effects of GH remain ill defined in complex tissues such as the growth…”
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Sustained Alterations of Hypothalamic Tanycytes During Posttraumatic Hypopituitarism in Male Mice by Osterstock, Guillaume, El Yandouzi, Taoufik, Romanò, Nicola, Carmignac, Danielle, Langlet, Fanny, Coutry, Nathalie, Guillou, Anne, Schaeffer, Marie, Chauvet, Norbert, Vanacker, Charlotte, Galibert, Evelyne, Dehouck, Bénédicte, Robinson, Iain C. A. F, Prévot, Vincent, Mollard, Patrice, Plesnila, Nikolaus, Méry, Pierre-François

“…Traumatic brain injury is a leading cause of hypopituitarism, which compromises patients' recovery, quality of life, and life span. To date, there are no means…”
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SOX2 Plays a Critical Role in the Pituitary, Forebrain, and Eye during Human Embryonic Development by Kelberman, Daniel, de Castro, Sandra C. P., Huang, Shuwen, Crolla, John A., Palmer, Rodger, Gregory, John W., Taylor, David, Cavallo, Luciano, Faienza, Maria F., Fischetto, Rita, Achermann, John C., Martinez-Barbera, Juan Pedro, Rizzoti, Karine, Lovell-Badge, Robin, Robinson, Iain C. A. F., Gerrelli, Dianne, Dattani, Mehul T.

“…Context: Heterozygous, de novo mutations in the transcription factor SOX2 are associated with bilateral anophthalmia or severe microphthalmia and…”
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Sexually Dimorphic Distribution of sst2A Somatostatin Receptors on Growth Hormone-Releasing Hormone Neurons in Mice by Bouyer, Karine, Loudes, Catherine, Robinson, Iain C. A. F, Epelbaum, Jacques, Faivre-Bauman, Annie

“…The pulsatile pattern of GH secretion exhibits sexual dimorphism that is likely to depend on somatostatin (SRIH) effects on somatoliberin (GHRH) neurons in the…”
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SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland by Fauquier, Teddy, Rizzoti, Karine, Dattani, Mehul, Lovell-Badge, Robin, Robinson, Iain C.A.F

“…The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing hormonal demands throughout life. There is circumstantial…”
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Visceral Obesity without Insulin Resistance in Late-Onset Obesity Rats by Bains, Randip K, Wells, Sara E, Flavell, Dave M, Fairhall, Keith M, Strom, Molly, Le Tissier, Paul, Robinson, Iain C. A. F

“…We describe a line of transgenic rats in which the males develop a unique autosomal dominant, late-onset obesity (LOB) phenotype. LOB males gradually…”
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Autosomal Dominant Growth Hormone Deficiency Disrupts Secretory Vesicles in Vitro and in Vivo in Transgenic Mice by McGuinness, Lindsay, Magoulas, Charalambos, Sesay, Abdul K, Mathers, Kathleen, Carmignac, Danielle, Manneville, Jean-Baptiste, Christian, Helen, Phillips, John A, Robinson, Iain C. A. F

“…Autosomal dominant GH deficiency type II (IGHDII) is often associated with mutations in the human GH gene (GH1) that give rise to products lacking exon-3…”
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Bone Marrow Adipocytes: A Neglected Target Tissue for Growth Hormone by Gevers, Evelien F, Loveridge, Nigel, Robinson, Iain C. A. F

“…Bone marrow (BM) contains numerous adipocytes. These share a common precursor with osteoblasts and chondrocytes, but their function is unknown. It is unclear…”
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Blanking induced damage in thin 3.2% silicon steel sheets by Ghadbeigi, H., Al-Rubaye, A., Robinson, F. C. J., Hawezy, D., Birosca, S., Atallah, K.

“…The cores of electrical motors and transformers are made by blanking, piercing and stacking of thin metallic sheets having various features cut from the…”
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Hypothalamic Growth Hormone Secretagogue-Receptor (GHS-R) Expression Is Regulated by Growth Hormone in the Rat by Bennett, Pamela A, Thomas, Gregory B, Howard, Andrew D, Feighner, Scott D, Van der Ploeg, Lex H. T, Smith, Roy G, Robinson, Iain C. A. F

“…Synthetic GH secretagogues (GHSs) act via a receptor (GHS-R) distinct from that for GH-releasing hormone (GHRH). We have studied the hypothalamic expression…”
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Rescue of Pituitary Function in a Mouse Model of Isolated Growth Hormone Deficiency Type II by RNA Interference by Shariat, Nikki, Ryther, Robin C. C, Phillips, John A, Robinson, Iain C. A. F, Patton, James G

“…Splicing mutations in the human GH (hGH) gene (GH-1) that cause skipping of exon 3 result in a form of GH deficiency termed isolated GH deficiency type II…”
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Isolated Autosomal Dominant Growth Hormone Deficiency: Stimulating Mutant GH-1 Gene Expression Drives GH-1 Splice-Site Selection, Cell Proliferation, and Apoptosis by Salemi, Souzan, Yousefi, Shida, Lochmatter, Didier, Eblé, Andrée, Deladoëy, Johnny, Robinson, Iain C. A. F, Simon, Hans-Uwe, Mullis, Primus E

“…The majority of mutations that cause isolated GH deficiency type II (IGHD II) affect splicing of GH-1 transcripts and produce a dominant-negative GH isoform…”
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Mortality patterns among electrical workers employed in the U.S. Construction Industry, 1982-1987 by Robinson, C.F., Petersen, M., Palu, S.

“…Background Studies of electrical workers in the utility and manufacturing industries have reported excess site‐specific cancer. No previous studies of…”
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Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood by Sanchez-Cardenas, Claudia, Fontanaud, Pierre, He, Zhenhe, Lafont, Chrystel, Meunier, Anne-Cécile, Schaeffer, Marie, Carmignac, Danielle, Molino, François, Coutry, Nathalie, Bonnefont, Xavier, Gouty-Colomer, Laurie-Anne, Gavois, Elodie, Hodson, David J., Le Tissier, Paul, Robinson, Iain C. A. F., Mollard, Patrice, Gustafsson, Jan-Åke

“…There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine…”
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Activation of the Hypothalamo-Pituitary-Adrenal Axis by the Growth Hormone (GH) Secretagogue, GH-Releasing Peptide-6, in Rats by Thomas, Gregory B, Fairhall, Keith M, Robinson, Iain C. A. F

“…GH-releasing hexapeptide (GHRP-6) is a synthetic secretagogue that stimulates the release of GH by acting at both hypothalamic and pituitary sites. GHRPs also…”
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Pooled Reanalysis of Cancer Mortality among Five Cohorts of Workers in wood-related Industries by Demers, Paul A, Boffetta, Paolo, Kogevinas, Manolis, Blair, Aaron, Miller, Barry A, Robinson, Cynthia F, Roscoe, Robert J, Winter, Paul D, Colin, Didier, Matos, Elena, Vainio, Harri

“…Objectives To provide more information regarding the risk of cancer associated with wood dust, a pooled reanalysis of data from five cohort studies was…”
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Growth Hormone-Releasing Hormone (GHRH) Neurons in GHRH-Enhanced Green Fluorescent Protein Transgenic Mice: A Ventral Hypothalamic Network by Balthasar, N, Mery, P.-F, Magoulas, C. B, Mathers, K. E, Martin, A, Mollard, P, Robinson, I. C. A. F

“…The hypothalamic GHRH neurons secrete pulses of GHRH to generate episodic GH secretion, but little is known about the mechanisms involved. We have made…”
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