Search Results - "Robinson, B. W. S."

Harnessing the immune response to treat cancer by Steer, H J, Lake, R A, Nowak, A K, Robinson, B W S

“…It is well established that the immune system has the capacity to attack malignant cells. During malignant transformation cells acquire numerous molecular and…”
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A multicentre phase II study of cisplatin and gemcitabine for malignant mesothelioma by NOWAK, A. K, BYRNE, M. J, WILLIAMSON, R, RYAN, G, SEGAL, A, FIELDING, D, MITCHELL, P, MUSK, A. W, ROBINSON, B. W. S

“…Our previous phase II study of cisplatin and gemcitabine in malignant mesothelioma showed a 47.6% (95% CI 26.2-69.0%) response rate with symptom improvement in…”
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Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells by Jackaman, C, Cornwall, S, Lew, A. M, Zhan, Y, Robinson, B. W. S, Nelson, D. J

“…The aim of the present study was to define the point at which mesothelioma T-cell responses fail in order to design better immunotherapies. A murine model of…”
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A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma by Nowak, A.K., Cook, A.M., McDonnell, A.M., Millward, M.J., Creaney, J., Francis, R.J., Hasani, A., Segal, A., Musk, A.W., Turlach, B.A., McCoy, M.J., Robinson, B.W.S., Lake, R.A.

“…Data from murine models suggest that CD40 activation may synergize with cytotoxic chemotherapy. We aimed to determine the maximum tolerated dose (MTD) and…”
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Gene therapy for malignant mesothelioma: beyond the infant years by van der Most, R G, Robinson, B W S, Nelson, D J

“…Mesothelioma may be particularly well suited for gene therapy treatment owing to its accessibility, allowing both intrapleural and intratumoral gene delivery…”
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Neo-antigen specific T cell responses indicate the presence of metastases before imaging by Fear, V. S., Forbes, C. A., Chee, J., Ma, S., Neeve, S., Celliers, L., Fisher, S. A., Dick, I., Creaney, J., Robinson, B. W. S.

“…Non-small cell lung cancer (NSCLC) causes 19% of all Australian cancer deaths, with a 5-year survival post-resection of around 60%. Post-operative recurrence…”
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Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma by Creaney, Jenette, Yeoman, Deborah, Naumoff, Leanne K, Hof, Michelle, Segal, Amanda, Musk, Arthur William, De Klerk, Nicholas, Horick, Nora, Skates, Steven J, Robinson, Bruce W S

“…Background: The diagnosis of malignant mesothelioma is frequently difficult, the most common differential diagnosis being reactive pleural conditions and…”
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Decoding dangerous death: how cytotoxic chemotherapy invokes inflammation, immunity or nothing at all by van der Most, R G, Currie, A J, Robinson, B W S, Lake, R A

“…Chemotherapy and immunotherapy can be either synergistic or antagonistic modalities in the treatment of cancer. Cytotoxic chemotherapy not only affects the…”
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Overexpression and altered glycosylation of MUC1 in malignant mesothelioma by Creaney, J, Segal, A, Sterrett, G, Platten, M A, Baker, E, Murch, A R, Nowak, A K, Robinson, B W S, Millward, M J

“…Current interest in the MUC1/EMA mucin relates to its role in malignancy, and its potential as a therapeutic target. MUC1/EMA expression has been observed in…”
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Effects of different density gradient separation techniques on neutrophil function by Venaille, T J, Misso, N L, Phillips, M J, Robinson, B W, Thompson, P J

“…Investigation of the pathogenesis of inflammatory diseases has involved assessment of polymorphonuclear leukocyte (PMN) activity and a variety of techniques…”
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Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence by Holt, P G, Clough, J B, Holt, B J, Baron-Hay, M J, Rose, A H, Robinson, B W, Thomas, W R

“…Recent in vitro studies suggest that IgE production in adults is co-ordinately regulated by negative signals from gamma IFN-producing CD4+ T-helper-1 (TH-1)…”
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Establishment of a murine model of malignant mesothelioma by Davis, M R, Manning, L S, Whitaker, D, Garlepp, M J, Robinson, B W

“…Malignant mesothelioma (MM) is an aggressive tumour of the serosal cavities which is associated with previous asbestos exposure and is generally found to be…”
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Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium by Upham, J W, Holt, B J, Baron-Hay, M J, Yabuhara, A, Hales, B J, Thomas, W R, Loh, R K, O'Keeffe, P T, Palmer, L, Le Souef, P N

“…It is widely held that in vitro T cell responses to allergens are more prominent in atopic than in normal individuals, though this conclusion is based upon…”
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p53 autoantibodies in patients with malignant mesothelioma: stability through disease progression by CREANEY, J, MCLAREN, B. M, STEVENSON, S, MUSK, A. W, DE KLERK, N, ROBINSON, B. W. S, LAKE, R. A

“…Malignant mesothelioma (MM) generally occurs as a pleural tumour, related to the inhalation of asbestos fibres. It is highly aggressive and largely…”
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Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used by Fear, Vanessa S., Forbes, Catherine A., Neeve, Samuel A., Fisher, Scott A., Chee, Jonathan, Waithman, Jason, Ma, Shao Kang, Lake, Richard, Nowak, Anna K., Creaney, Jenette, Brown, Matthew D., Saunders, Christobel, Robinson, Bruce W. S.

“…Surgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of…”
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Recent advances in molecular biological techniques and their relevance to pulmonary research by Robinson, B W S, Erle, D J, Jones, D A, Shapiro, S, Metzger, W J, Albelda, S M, Parks, W C, Boylan, A

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Interleukin-6 involvement in mesothelioma pathobiology : inhibition by interferon α immunotherapy by BIELEFELDT-OHMANN, H, MARZO, A. L, HIMBECK, R. P, JARNICKI, A. G, ROBINSON, B. W. S, FITZPATRICK, D. R

“…A role for interleukin-6 (IL-6) in malignant mesothelioma has been suggested by the clinically presenting symptoms of mesothelioma patients, which include…”
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Author's response: Inconsistent results or inconsistent methods? A plea for standardisation of biomarker sampling in mesothelioma studies by Creaney, Jenette, Robinson, Bruce W S

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Patho- and immunobiology of malignant mesothelioma : characterisation of tumour infiltrating leucocytes and cytokine production in a murine model by BIELEFELDT-OHMANN, H, FITZPATRICK, D. R, MARZO, A. L, JARNICKI, A. G, HIMBECK, R. P, DAVIS, M. R, MANNING, L. S, ROBINSON, B. W. S

“…Malignant mesothelioma (MM) is an aggressive, uniformly fatal serosal tumour, usually associated with asbestos exposure, for which there currently is no…”
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Simian virus (SV) 40 like sequences in cell lines and tumour biopsies from Australian malignant mesotheliomas by Mclaren, B. R., Haenel, T., Stevenson, S., Mukherjee, S., Robinson, B. W. S., Lake, R. A.

“…Background: Simian virus (SV) 40 sequences have been found in some, but not all studies of mesotheliomas. This virus is known to cause tumours in rodents but…”
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