Search Results - "Robins, R. K"

Modulation of leukocyte genetic expression by novel purine nucleoside analogs. A new approach to antitumor and antiviral agents by Bonnet, Pierre A, Robins, Roland K

“…Stimulation of the immune system has long been recognized to be highly effective in the prevention and the treatment of viral infection. Also, recent studies…”
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Synthesis of 2'-deoxytubercidin, 2'-deoxyadenosine, and related 2'-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure by Kazimierczuk, Zygmunt, Cottam, Howard B, Revankar, Ganapathi R, Robins, Roland K

“…A general and stereospecific synthesis has been developed for the direct preparation of 2'-deoxy- beta -D-ribofuranosylpurine analogues including…”
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Induction of Megakaryocytic Differentiation and Modulation of Protein Kinase Gene Expression by Site-Selective cAMP Analogs in K-562 Human Leukemic Cells by Tortora, Giampaolo, Clair, Timothy, Katsaros, Dionyssios, Ally, Shamsia, Colamonici, Oscar, Neckers, Leonard M., Tagliaferri, Pierosandro, Jahnsen, Tore, Robins, Roland K., Cho-Chung, Yoon Sang

“…Two classes (site 1- and site 2-selective) of cAMP analogs, which either alone or in combination demonstrate a preference for binding to type II rather than…”
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Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs by Tagliaferri, P, Katsaros, D, Clair, T, Neckers, L, Robins, R K, Cho-Chung, Y S

“…Eighteen site-selective cAMP analogs modified at either the C-8 position or the C-6 position were tested for their growth regulatory effects on the Harvey…”
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Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses by HUGGINS, J. W, ROBINS, R. K, CANONICO, P. G

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Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent by KIRSI, J. J, NORTH, J. A, MCKERNAN, P. A, MURRAY, B. K, CANONICO, P. G, HUGGINS, J. W, SRIVASTAVA, P. C, ROBINS, R. K

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Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent by SMEE, D. F, ALAGHAMANDAN, H. A, COTTAM, H. B, SHARMA, B. S, JOLLEY, W. B, ROBINS, R. K

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Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus by Gilbert, B E, Wyde, P R, Wilson, S Z, Robins, R K

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2-.beta.-D-ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases by Robins, R. K, Srivastava, P. C, Narayanan, V. L, Plowman, J, Paull, K. D

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Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro by OHMURA, E, WAKAI, K, ISOZAKI, O, MURAKAMI, H, ONODA, N, EMOTO, N, SHIZUME, K, TSUSHIMA, T, DEMURA, H, ROBINS, R. K

“…The effects of cholera toxin (CT) and 8-chloro-cAMP (8-Cl-cAMP) on cell growth were investigated using two human pancreatic carcinoma cell lines (MIA PaCa-2,…”
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Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity by SMEE, D. F, MCKERNAN, P. A, DEE NORD, L, WILLIS, R. C, PETRIE, C. R, RILEY, T. M, REVANKAR, G. R, ROBINS, R. K, SMITH, R.

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Structural Mimicry of Adenosine by the Antitumor Agents 4-methoxy- and 4-amino-8-(β -D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine as Viewed by a Molecular Modeling Method by Ghose, Arup K., Viswanadhan, Vellarkad N., Sanghvi, Yogesh S., Nord, L. Dee, Willis, Randall C., Revankar, Ganapathi R., Robins, Roland K.

“…A rationale for the antitumor activity of 4-methoxy- and 4-amino-8-(β -D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (β -MRPP and β -ARPP, respectively) was…”
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Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents by Nagahara, Katsuhiko, Anderson, Jack D, Kini, Ganesh D, Dalley, N. Kent, Larson, Steven B, Smee, Donald F, Jin, Ai, Sharma, Brahma S, Jolley, Weldon B

“…Novel analogues of the naturally occurring purine nucleosides were synthesized in the thiazolo[4,5-d]pyrimidine ring system to determine the immunomodulatory…”
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Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth by Katsaros, Dionyssios, Tortora, Giampaolo, Tagliaferri, Pierosandro, Clair, Timothy, Ally, Shamsia, Neckers, Leonard, Robins, Roland K., Cho-Chung, Yoon Sang

“…Site-selective cyclic AMP analogs bind to site 1 or site 2 of the known cAMP-binding sites depending on the position of substituents on the purine ring, either…”
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Site-Selective cAMP Analogs at Micromolar Concentrations Induce Growth Arrest and Differentiation of Acute Promyelocytic, Chronic Myelocytic, and Acute Lymphocytic Human Leukemia Cell Lines by Giampaolo, Tortora, Pierosandro, Tagliaferri, Timothy, Clair, Oscar, Colamonici, Leonard, M.Neckers, Roland, K.Robins, Yoon Sang, Cho-Chung

“…Cyclic AMP (cAMP)-dependent protein kinase may play a role in the functional and morphological differentiation of leukemic cells. In this study, we showed that…”
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Deoxycytidine Kinase-Mediated Toxicity of Deoxyadenosine Analogs toward Malignant Human Lymphoblasts in vitro and toward Murine L1210 Leukemia in vivo by Carson, Dennis A., Wasson, Donald B., Kaye, Jonathan, Ullman, Buddy, Martin, David W., Robins, Roland K., Montgomery, John A.

“…An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) produces selective lymphopenia and immunodeficiency disease in humans…”
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Synthesis and biological evaluation of certain C-4 substituted pyrazolo[3,4-b]pyridine nucleosides by Sanghvi, Yogesh S, Larson, Steven B, Willis, Randall C, Robins, Roland K, Revankar, Ganapathi R

“…A series of C-4 substituted pyrazolo[3,4-b]pyridine nucleosides have been synthesized and evaluated for their biological activity. Successful synthesis of…”
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Biological activity of analogs of guanine and guanosine against American Trypanosoma and Leishmania spp by AVILA, J. L, ROJAS, T, AVILA, A, POLEGRE, M. A, ROBINS, R. K

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Polycytidylate and poly(7-deazaguanylate) : a pair of complementary templates by REMBOLD, H, ROBINS, R. K, SEELA, F, ORGEL, L. E

“…We have studied the template-directed oligomerization on polycytidylic acid of the 5'-phosphoro(2-methyl)imidazolides of a number of analogues of guanosine…”
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Synthesis of certain nucleoside methylenediphosphonate sugars as potential inhibitors of glycosyltransferases by Vaghefi, Morteza M, Bernacki, Ralph J, Hennen, William J, Robins, Roland K

“…The synthesis of alpha-D-glucopyranosyl 1-(methylenediphosphonate) (11), alpha-D-galactopyranosyl 1-(methylenediphosphonate) (14), and alpha-D-mannopyranosyl…”
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