Search Results - "Robertus, Jon D"

The Cobalamin-Independent Methionine Synthase Enzyme Captured in a Substrate-Induced Closed Conformation by Ubhi, Devinder K., Robertus, Jon D.

“…The cobalamin-independent methionine synthase enzyme catalyzes a challenging reaction: the direct transfer of a methyl from…”
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Structure-based design of ricin inhibitors by Jasheway, Karl, Pruet, Jeffrey, Anslyn, Eric V, Robertus, Jon D

“…Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism…”
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Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics by Wiget, Paul A., Manzano, Lawrence A., Pruet, Jeff M., Gao, Grace, Saito, Ryota, Monzingo, Arthur F., Jasheway, Karl R., Robertus, Jon D., Anslyn, Eric V.

“…Several 7-aminoamido-pterins were synthesized to evaluate the electronic and biochemical subtleties observed in the ‘linker space’ when…”
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The Structure of the Minimal Relaxase Domain of MobA at 2.1 Å Resolution by Monzingo, Arthur F., Ozburn, Angela, Xia, Shuangluo, Meyer, Richard J., Robertus, Jon D.

“…The plasmid R1162 encodes proteins that enable its conjugative mobilization between bacterial cells. It can transfer between many different species and is one…”
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Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to Domain 4 of the Anthrax Protective Antigen by Leysath, Clinton E., Monzingo, Arthur F., Maynard, Jennifer A., Barnett, Jason, Georgiou, George, Iverson, Brent L., Robertus, Jon D.

“…The virulence of Bacillus anthracis is critically dependent on the cytotoxic components of the anthrax toxin, lethal factor (LF) and edema factor (EF). LF and…”
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Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans by Prasannan, Priya, Suliman, Huda S., Robertus, Jon D.

“…Fungal methionine synthase catalyzes the transfer of a methyl group from 5-methyl-tetrahydrofolate to homocysteine to create methionine. The enzyme, called…”
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Structure-Based Design and Characterization of Novel Platforms for Ricin and Shiga Toxin Inhibition by Miller, Darcie J, Ravikumar, Kabyadi, Shen, Huafeng, Suh, Jung-Keun, Kerwin, Sean M, Robertus, Jon D

“…Ribosome inhibiting proteins, RIPs, are a widespread family of toxic enzymes. Ricin is a plant toxin used as a poison and biological warfare agent; shiga toxin…”
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Kinetic Properties of Chitinase-1 from the Fungal Pathogen Coccidioides immitis by Fukamizo, Tamo, Sasaki, Chiye, Schelp, Elisabeth, Bortone, Kara, Robertus, Jon D

“…The endochitinase from Coccidioides immitis (CiX1) is a member of the class 18 chitinase family. Here we show the enzyme functions by a retaining catalytic…”
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Structural Analysis of a Fungal Methionine Synthase with Substrates and Inhibitors by Ubhi, Devinder, Kago, Grace, Monzingo, Arthur F., Robertus, Jon D.

“…The cobalamin-independent methionine synthase from Candida albicans, known as Met6p, is a 90-kDa enzyme that consists of two (βα)8 barrels. The active site is…”
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X-ray structures of NS1 effector domain mutants by Xia, Shuangluo, Robertus, Jon D.

“…The influenza A virus nonstructural protein NS1 is a multifunctional dimeric protein that acts as a potent inhibitor of the host cellular antiviral state. The…”
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Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones} by Mandal, Subrata, Li, Wen Tai, Bai, Yan, Robertus, Jon D, Kerwin, Sean M

“…Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due…”
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Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum by Suh, J.K, Poulsen, L.L, Ziegler, D.M, Robertus, J.D

“…The flavin-containing monooxygenase from yeast (yFMO) catalyzes the O(2)- and NADPH-dependent oxidations of biological thiols, including oxidation of…”
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Teaching through Research: Alignment of Core Chemistry Competencies and Skills within a Multidisciplinary Research Framework by Ghanem, Eman, Long, S. Reid, Rodenbusch, Stacia E, Shear, Ruth I, Beckham, Josh T, Procko, Kristen, DePue, Lauren, Stevenson, Keith J, Robertus, Jon D, Martin, Stephen, Holliday, Bradley, Jones, Richard A, Anslyn, Eric V, Simmons, Sarah L

“…Innovative models of teaching through research have broken the long-held paradigm that core chemistry competencies must be taught with predictable, scripted…”
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Structure of NS1A effector domain from the influenza A/Udorn/72 virus by Xia, Shuangluo, Monzingo, Arthur F., Robertus, Jon D.

“…The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional…”
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Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen by Wahome, Paul G., Bai, Yan, Neal, Lori M., Robertus, Jon D., Mantis, Nicholas J.

“…The Category B agents, ricin and shiga toxin (Stx), are RNA N-glycosidases that target a highly conserved adenine residue within the sarcin-ricin loop of…”
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The X-ray structure of ricin A chain with a novel inhibitor by Bai, Yan, Monzingo, Arthur F., Robertus, Jon D.

“…Ricin is a potent heterodimeric cytotoxin; the B chain binds eucaryotic cell surfaces aiding uptake and the A chain, RTA, reaches the cytoplasm where it…”
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pH-induced structural changes regulate histidine decarboxylase activity in Lactobacillus 30a by Schelp, Elisabeth, Worley, Scott, Monzingo, Arthur F, Ernst, Stephen, Robertus, Jon D

“…Histidine decarboxylase (HDC) from Lactobacillus 30a produces histamine that is essential to counter waste acids, and to optimize cell growth. The HDC trimer…”
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Yeast Flavin-Containing Monooxygenase Is Induced by the Unfolded Protein Response by Suh, Jung-Keun, Robertus, Jon D.

“…Flavin-containing monooxygenase from yeast (yFMO) carries out the O2- and NADPH-dependent oxidation of biological thiols, including oxidizing glutathione to…”
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Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors by You, Lei, Cho, Eun Jeong, Leavitt, John, Ma, Li-Chung, Montelione, Gaetano T., Anslyn, Eric V., Krug, Robert M., Ellington, Andrew, Robertus, Jon D.

“…A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An…”
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Peptide-Conjugated Pterins as Inhibitors of Ricin Toxin A by Saito, Ryota, Pruet, Jeff M, Manzano, Lawrence A, Jasheway, Karl, Monzingo, Arthur F, Wiget, Paul A, Kamat, Ishan, Anslyn, Eric V, Robertus, Jon D

“…Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide…”
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