Search Results - "Robertson, Shelly J."

FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga by Chiramel, Abhilash I., Dougherty, Jonathan D., Nair, Vinod, Robertson, Shelly J., Best, Sonja M.

“…Selective autophagy of the endoplasmic reticulum (termed ER-phagy) is controlled by members of the FAMI34 reticulon protein family. Here we used mouse…”
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The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1 by Göertz, Giel P, McNally, Kristin L, Robertson, Shelly J, Best, Sonja M, Pijlman, Gorben P, Fros, Jelke J

“…Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has evolved effective mechanisms to counteract the type I interferon (IFN) response. Upon…”
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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation by Chiramel, Abhilash I, Meyerson, Nicholas R, McNally, Kristin L, Broeckel, Rebecca M, Montoya, Vanessa R, Méndez-Solís, Omayra, Robertson, Shelly J, Sturdevant, Gail L, Lubick, Kirk J, Nair, Vinod, Youseff, Brian H, Ireland, Robin M, Bosio, Catharine M, Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M, Taylor, R Travis, Bouamr, Fadila, Sawyer, Sara L, Best, Sonja M

“…Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity…”
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A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis by Broeckel, Rebecca M, Feldmann, Friederike, McNally, Kristin L, Chiramel, Abhilash I, Sturdevant, Gail L, Leung, Jacqueline M, Hanley, Patrick W, Lovaglio, Jamie, Rosenke, Rebecca, Scott, Dana P, Saturday, Greg, Bouamr, Fadila, Rasmussen, Angela L, Robertson, Shelly J, Best, Sonja M

“…Kyasanur Forest disease virus (KFDV) and the closely related Alkhurma hemorrhagic disease virus (AHFV) are emerging flaviviruses that cause severe viral…”
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Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function by Robertson, Shelly J, Lubick, Kirk J, Freedman, Brett A, Carmody, Aaron B, Best, Sonja M

“…Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a leading cause of viral encephalitis in Europe and Asia. Dendritic cells (DCs),…”
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TRIM79α, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase by Taylor, R Travis, Lubick, Kirk J, Robertson, Shelly J, Broughton, James P, Bloom, Marshall E, Bresnahan, Wade A, Best, Sonja M

“…In response to virus infection, type I interferons (IFNs) induce several genes, most of whose functions are largely unknown. Here, we show that the tripartite…”
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Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist by BEST, Sonja M, MORRIS, Keely L, SHANNON, Jeffrey G, ROBERTSON, Shelly J, MITZEL, Dana N, PARK, Gregory S, BOER, Elena, WOLFINBARGER, James B, BLOOM, Marshall E

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Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages by Cockrell, Diane C, Long, Carrie M, Robertson, Shelly J, Shannon, Jeffrey G, Miller, Heather E, Myers, Lara, Larson, Charles L, Starr, Tregei, Beare, Paul A, Heinzen, Robert A

“…Published data show that murine bone marrow-derived macrophages (BMDM) restrict growth of avirulent phase II, but not virulent phase I, Coxiella burnetii…”
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A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection by Dutta, Mukta, Robertson, Shelly J., Okumura, Atsushi, Scott, Dana P., Chang, Jean, Weiss, Jeffrey M., Sturdevant, Gail L., Feldmann, Friederike, Haddock, Elaine, Chiramel, Abhilash I., Ponia, Sanket S., Dougherty, Jonathan D., Katze, Michael G., Rasmussen, Angela L., Best, Sonja M.

“…The unprecedented 2013–2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor…”
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Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance by Vinton, Carol L, Magaziner, Samuel J, Dowd, Kimberly A, Robertson, Shelly J, Amaro-Carambot, Emerito, Karmele, Erik P, Ortiz, Alexandra M, Starke, Carly E, Mudd, Joseph C, Whitehead, Stephen S, Best, Sonja M, Pierson, Theodore C, Hickman, Heather D, Brenchley, Jason M

“…Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly…”
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Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression by Lubick, Kirk J., Robertson, Shelly J., McNally, Kristin L., Freedman, Brett A., Rasmussen, Angela L., Taylor, R. Travis, Walts, Avram D., Tsuruda, Seitaro, Sakai, Mizuki, Ishizuka, Mariko, Boer, Elena F., Foster, Erin C., Chiramel, Abhilash I., Addison, Conrad B., Green, Richard, Kastner, Daniel L., Katze, Michael G., Holland, Steven M., Forlino, Antonella, Freeman, Alexandra F., Boehm, Manfred, Yoshii, Kentaro, Best, Sonja M.

“…Type I interferon (IFN-α/β or IFN-I) signals through two receptor subunits, IFNAR1 and IFNAR2, to orchestrate sterile and infectious immunity. Cellular…”
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Suppression of Acute Anti-Friend Virus CD8+ T-Cell Responses by Coinfection with Lactate Dehydrogenase-Elevating Virus by ROBERTSON, Shelly J, AMMANN, Christoph G, HASENKRUG, Kim J, MESSER, Ronald J, CARMODY, Aaron B, MYERS, Lara, DITTMER, Ulf, NAIR, Savita, GERLACH, Nicole, EVANS, Leonard H, CAFRUNY, William A

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VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain by Marzi, Andrea, Robertson, Shelly J., Haddock, Elaine, Feldmann, Friederike, Hanley, Patrick W., Scott, Dana P., Strong, James E., Kobinger, Gary, Best, Sonja M., Feldmann, Heinz

“…The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the…”
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Tick-borne flaviviruses: dissecting host immune responses and virus countermeasures by Robertson, Shelly J., Mitzel, Dana N., Taylor, R. Travis, Best, Sonja M., Bloom, Marshall E.

“…The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus , includes a number of important human pathogens that cause serious neurological…”
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Interfer-on time: lessons from genetically diverse mouse models of SARS-CoV-2 infection by Robertson, Shelly J., Best, Sonja M.

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Immunobiology of Ebola and Lassa virus infections by Prescott, Joseph B., Marzi, Andrea, Safronetz, David, Robertson, Shelly J., Feldmann, Heinz, Best, Sonja M.

“…Key Points Ebola virus (EBOV) and Lassa virus (LASV) are two of the most important contemporary emerging viruses in Africa, both causing severe haemorrhagic…”
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The domiNO effect turns macrophage activation deadly by Robertson, Shelly J., Best, Sonja M.

“…Macrophage activation is essential for effective immunity to infection but can also contribute to disease through incompletely understood mechanisms. In this…”
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CD8+ T-Cell Dysfunction due to Cytolytic Granule Deficiency in Persistent Friend Retrovirus Infection by ZELINSKYY, Gennadiy, ROBERTSON, Shelly J, SCHIMMER, Simone, MESSER, Ronald J, HASENKRUG, Kim J, DITTMER, Ulf

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Envelope protein ubiquitination drives entry and pathogenesis of Zika virus by Giraldo, Maria I., Xia, Hongjie, Aguilera-Aguirre, Leopoldo, Hage, Adam, van Tol, Sarah, Shan, Chao, Xie, Xuping, Sturdevant, Gail L., Robertson, Shelly J., McNally, Kristin L., Meade-White, Kimberly, Azar, Sasha R., Rossi, Shannan L., Maury, Wendy, Woodson, Michael, Ramage, Holly, Johnson, Jeffrey R., Krogan, Nevan J., Morais, Marc C., Best, Sonja M., Shi, Pei-Yong, Rajsbaum, Ricardo

“…Zika virus (ZIKV) belongs to the family Flaviviridae , and is related to other viruses that cause human diseases. Unlike other flaviviruses, ZIKV infection can…”
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Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge by Hilligan, Kerry L, Namasivayam, Sivaranjani, Clancy, Chad S, O'Mard, Danielle, Oland, Sandra D, Robertson, Shelly J, Baker, Paul J, Castro, Ehydel, Garza, Nicole L, Lafont, Bernard A P, Johnson, Reed, Ronchese, Franca, Mayer-Barber, Katrin D, Best, Sonja M, Sher, Alan

“…In addition to providing partial protection against pediatric tuberculosis, vaccination with bacille Calmette-Guérin (BCG) has been reported to confer…”
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