Search Results - "Robertson, Murray"

Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni by Meister, Isabel, Ingram-Sieber, Katrin, Cowan, Noemi, Todd, Matthew, Robertson, Murray N, Meli, Claudia, Patra, Malay, Gasser, Gilles, Keiser, Jennifer

“…A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the…”
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In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (η6‑Praziquantel)Cr(CO)3 Derivatives by Patra, Malay, Ingram, Katrin, Leonidova, Anna, Pierroz, Vanessa, Ferrari, Stefano, Robertson, Murray N, Todd, Matthew H, Keiser, Jennifer, Gasser, Gilles

“…In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula…”
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An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials by Tse, Edwin G, Aithani, Laksh, Anderson, Mark, Cardoso-Silva, Jonathan, Cincilla, Giovanni, Conduit, Gareth J, Galushka, Mykola, Guan, Davy, Hallyburton, Irene, Irwin, Benedict W. J, Kirk, Kiaran, Lehane, Adele M, Lindblom, Julia C. R, Lui, Raymond, Matthews, Slade, McCulloch, James, Motion, Alice, Ng, Ho Leung, Öeren, Mario, Robertson, Murray N, Spadavecchio, Vito, Tatsis, Vasileios A, van Hoorn, Willem P, Wade, Alexander D, Whitehead, Thomas M, Willis, Paul, Todd, Matthew H

“…The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, Plasmodium falciparum, by targeting PfATP4, an essential…”
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A unified ML framework for solubility prediction across organic solvents by Vassileiou, Antony D, Robertson, Murray N, Wareham, Bruce G, Soundaranathan, Mithushan, Ottoboni, Sara, Florence, Alastair J, Hartwig, Thoralf, Johnston, Blair F

“…We report a single machine learning (ML)-based model to predict the solubility of drug/drug-like compounds across 49 organic solvents, extensible to more. By…”
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Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers by Anthony, Nahoum G, Baiget, Jessica, Berretta, Giacomo, Boyd, Marie, Breen, David, Edwards, Joanne, Gamble, Carly, Gray, Alexander I, Harvey, Alan L, Hatziieremia, Sophia, Ho, Ka Ho, Huggan, Judith K, Lang, Stuart, Llona-Minguez, Sabin, Luo, Jia Lin, McIntosh, Kathryn, Paul, Andrew, Plevin, Robin J, Robertson, Murray N, Scott, Rebecca, Suckling, Colin J, Sutcliffe, Oliver B, Young, Louise C, Mackay, Simon P

“…IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and…”
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‘You Scratch My Back and I’ll Scratch Yours’? Support to Academics Who Are Carers in Higher Education by Moreau, Marie-Pierre, Robertson, Murray

“…In recent years, it has become common for individuals to juggle employment and unpaid care work. This is just as true for the England-based academic workforce,…”
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Open source drug discovery - a limited tutorial by Robertson, Murray N, Ylioja, Paul M, Williamson, Alice E, Woelfle, Michael, Robins, Michael, Badiola, Katrina A, Willis, Paul, Olliaro, Piero, Wells, Timothy N C, Todd, Matthew H

“…Open science is a new concept for the practice of experimental laboratory-based research, such as drug discovery. The authors have recently gained experience…”
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Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines by Ihmaid, Saleh K., Al-Rawi, Jasim M.A., Bradley, Christopher J., Angove, Michael J., Robertson, Murray N.

“…A number of new 2-(pyridin-3-ylamino)-4H-(substituted) benz[e]-1,3-oxazin-4-ones were synthesized 10a–g. These were then reacted with the hydro-halogen salt of…”
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Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines by Ihmaid, Saleh, Al-Rawi, Jasim, Bradley, Christopher, Angove, Michael J., Robertson, Murray N., Clark, Rachel L.

“…Twelve new O-substituted-morpholino-naphtho-oxazines were synthesised, characterised and used for DNA-PK IC 50 evaluation. The compound 18 is the most potent…”
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The Drug Discovery Portal: a resource to enhance drug discovery from academia by Clark, Rachel L., Johnston, Blair F., Mackay, Simon P., Breslin, Catherine J., Robertson, Murray N., Harvey, Alan L.

“…Drug discovery in universities is usually associated with research on drug targets and mechanisms, but more recently there have been efforts to progress from…”
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Experiences with a researcher-centric ELN by Badiola, Katrina A, Bird, Colin, Brocklesby, William S, Casson, John, Chapman, Richard T, Coles, Simon J, Cronshaw, James R, Fisher, Adam, Frey, Jeremy G, Gloria, Danmar, Grossel, Martin C, Hibbert, D Brynn, Knight, Nicola, Mapp, Lucy K, Marazzi, Luke, Matthews, Brian, Milsted, Andy, Minns, Russell S, Mueller, Karl T, Murphy, Kelly, Parkinson, Tim, Quinnell, Rosanne, Robinson, John S, Robertson, Murray N, Robins, Michael, Springate, Emma, Tizzard, Graham, Todd, Matthew H, Williamson, Alice E, Willoughby, Cerys, Yang, Erica, Ylioja, Paul M

“…Electronic Laboratory Notebooks (ELNs) are progressively replacing traditional paper books in both commercial research establishments and academic…”
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Two-Dimensional Versus Transthoracic Real-Time Three-Dimensional Echocardiography in the Evaluation of the Mechanisms and Sites of Atrioventricular Valve Regurgitation in a Congenital Heart Disease Population by Takahashi, Ken, MD, Mackie, Andrew S., MD, Rebeyka, Ivan M., MD, Ross, David B., MD, Robertson, Murray, MD, Dyck, John D., MD, Inage, Akio, MD, Smallhorn, Jeffrey F., MBBS

“…Background Data are lacking on the utility of real-time three-dimensional (3D) echocardiography (RT3DE) in congenital abnormalities of the atrioventricular…”
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Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl- d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery by Sgraja, Tanja, Alphey, Magnus S, Ghilagaber, Stephanos, Marquez, Rudi, Robertson, Murray N, Hemmings, Jennifer L, Lauw, Susan, Rohdich, Felix, Bacher, Adelbert, Eisenreich, Wolfgang, Illarionova, Victoria, Hunter, William N

“…4-Diphosphocytidyl-2C-methyl- d-erythritol kinase (IspE) catalyses the ATP-dependent conversion of 4-diphosphocytidyl-2C-methyl- d-erythritol (CDPME) to…”
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The drug discovery portal: a computational platform for identifying drug leads from academia by Clark, Rachel L, Johnston, Blair F, Mackay, Simon P, Breslin, Catherine J, Robertson, Murray N, Sutcliffe, Oliver B, Dufton, Mark J, Harvey, Alan L

“…The Drug Discovery Portal (DDP) is a research initiative based at the University of Strathclyde in Glasgow, Scotland. It was initiated in 2007 by a group of…”
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Complete heart block and sudden death in mice overexpressing calreticulin by Nakamura, K, Robertson, M, Liu, G, Dickie, P, Nakamura, K, Guo, J Q, Duff, H J, Opas, M, Kavanagh, K, Michalak, M

“…The expression of calreticulin, a Ca(2+)-binding chaperone of the endoplasmic reticulum, is elevated in the embryonic heart, and because of impaired cardiac…”
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The Messiness of Care : an Account of Care as a Complex and Contestable Condition of Existence by Robertson, Murray

“…This thesis explores the multifaceted nature of care, insisting that care should be seen as a legitimate ground of moral and political contestation. Further, I…”
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Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism by Kantor, Paul F, Robertson, Murray A, Coe, James Y, Lopaschuk, Gary D

“…OBJECTIVES The purpose of this study was to determine the effect of volume overload hypertrophy in the newborn heart on the cardiac enzymes controlling fatty…”
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Là Buidhe Bealltainn/Fantastachd Ìmpireil by Gorman, Rody, Robertson, Murray

“…The work presents tercets from 'Là Buidhe Bealltainn' in a visually totemic form and framework which iterates the more ancient vibrations present in Rody…”
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Là Buidhe Bealltainn/Fantastachd Ìmpireil: May Day/Imperial Fantasy by Gorman, Rody, Robertson, Murray

“…The work presents tercets from 'Là Buidhe Bealltainn' in a visually totemic form and framework which iterates the more ancient vibrations present in Rody…”
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Autoimmune Cardiomyopathy and Heart Block Develop Spontaneously in HLA-DQ8 Transgenic IAβ Knockout NOD Mice by Elliott, John F., Liu, Junliang, Yuan, Zuan-Ning, Bautista-Lopez, Norma, Wallbank, Sarah L., Suzuki, Kunimasa, Rayner, David, Nation, Patrick, Robertson, Murray A., Liu, Gang, Kavanagh, Katherine M.

“…A line of nonobese diabetic (NOD) mice expressing the human diabetes-associated HLA-DQ8 transgene in the absence of mouse IAβfailed to show spontaneous…”
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