Search Results - "Robertson, Gail A."

hERG 1b is critical for human cardiac repolarization by Jones, David K., Liu, Fang, Vaidyanathan, Ravi, Eckhard, L. Lee, Trudeau, Matthew C., Robertson, Gail A.

“…Significance The 1a subunit of the human ether-à-go-go–related gene (hERG) potassium channel is a critical component of cardiac repolarization and the…”
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The Enigmatic Cytoplasmic Regions of KCNH Channels by Morais-Cabral, João H., Robertson, Gail A.

“…KCNH channels are expressed across a vast phylogenetic and evolutionary spectrum. In humans, they function in a wide range of tissues and serve as biomarkers…”
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Cotranslational association of mRNA encoding subunits of heteromeric ion channels by Liu, Fang, Jones, David K., de Lange, Willem J., Robertson, Gail A.

“…Oligomers of homomeric voltage-gated potassium channels associate early in biogenesis as the nascent proteins emerge from the polysome. Less is known about…”
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International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels by Gutman, George A, Chandy, K George, Grissmer, Stephan, Lazdunski, Michel, McKinnon, David, Pardo, Luis A, Robertson, Gail A, Rudy, Bernardo, Sanguinetti, Michael C, Stühmer, Walter, Wang, Xiaoliang

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A microtranslatome coordinately regulates sodium and potassium currents in the human heart by Eichel, Catherine A, Ríos-Pérez, Erick B, Liu, Fang, Jameson, Margaret B, Jones, David K, Knickelbine, Jennifer J, Robertson, Gail A

“…Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but…”
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The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase by Castro-Rodrigues, Artur F., Zhao, Yaxian, Fonseca, Fátima, Gabant, Guillaume, Cadene, Martine, Robertson, Gail A., Morais-Cabral, João H.

“…The Drosophila EAG (dEAG) potassium channel is the founding member of the superfamily of KNCH channels, which are involved in cardiac repolarization, neuronal…”
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Cardiac IKr Channels Minimally Comprise hERG 1a and 1b Subunits by Jones, Eugenia M C, Roti Roti, Elon C, Wang, Jinling, Delfosse, Samantha A, Robertson, Gail A

“…Previous studies suggest native cardiac I Kr channels are composed of alpha subunits encoded solely by the 1a transcript of the ERG1 gene. Using…”
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hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome by Trudeau, Matthew C, Leung, Lisa M, Roti, Elon Roti, Robertson, Gail A

“…Human ether-á-go-go-related gene (hERG) potassium channels are critical for cardiac action potential repolarization. Cardiac hERG channels comprise two primary…”
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Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening by Es-Salah-Lamoureux, Zeineb, Fougere, Robert, Xiong, Ping Yu, Robertson, Gail A, Fedida, David

“…hERG channels are physiologically important ion channels which mediate cardiac repolarization as a result of their unusual gating properties. These are very…”
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International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels by Gutman, George A, Chandy, K George, Adelman, John P, Aiyar, Jayashree, Bayliss, Douglas A, Clapham, David E, Covarriubias, Manuel, Desir, Gary V, Furuichi, Kiyoshi, Ganetzky, Barry, Garcia, Maria L, Grissmer, Stephan, Jan, Lily Y, Karschin, Andreas, Kim, Donghee, Kuperschmidt, Sabina, Kurachi, Yoshihisa, Lazdunski, Michel, Lesage, Florian, Lester, Henry A, McKinnon, David, Nichols, Colin G, O'Kelly, Ita, Robbins, Jonathan, Robertson, Gail A, Rudy, Bernardo, Sanguinetti, Michael, Seino, Susumu, Stuehmer, Walter, Tamkun, Michael M, Vandenberg, Carol A, Wei, Aguan, Wulff, Heike, Wymore, Randy S

“…This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which…”
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Heteromeric Assembly of Human Ether-à-go-go-related Gene (hERG) 1a/1b Channels Occurs Cotranslationally via N-terminal Interactions by Phartiyal, Pallavi, Jones, Eugenia M.C., Robertson, Gail A.

“…Alternate transcripts of the human ether-à-go-go-related gene (hERG1) encode two subunits, hERG 1a and 1b, which form potassium channels regulating cardiac…”
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hERG gating microdomains defined by S6 mutagenesis and molecular modeling by Wynia-Smith, Sarah L, Gillian-Daniel, Anne Lynn, Satyshur, Kenneth A, Robertson, Gail A

“…Human ether-à-go-go-related gene (hERG) channels mediate cardiac repolarization and bind drugs that can cause acquired long QT syndrome and life-threatening…”
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Endoplasmic Reticulum Retention and Rescue by Heteromeric Assembly Regulate Human ERG 1a/1b Surface Channel Composition by Phartiyal, Pallavi, Sale, Harinath, Jones, Eugenia M.C., Robertson, Gail A.

“…Defects in the trafficking of subunits encoded by the human ether-à-go-go-related gene (hERG1) can lead to catastrophic arrhythmias and sudden cardiac death…”
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HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family by Trudeau, Matthew C., Warmke, Jeffrey W., Ganetzky, Barry, Robertson, Gail A.

“…In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown…”
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A possible role for phase separation in heteromeric biogenesis of hERG1a/1b channels by Kannan, Sudharsan, Luong, Peter, Kasberg, William, Audhya, Anjon, Robertson, Gail A.

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Using the photo-crosslinkable non-canonical amino acid BZF to capture U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation in hERG potassium channels by Codding, Sara J., Robertson, Gail A., Trudeau, Matt C.

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A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels by Fergestad, Tim, Sale, Harinath, Bostwick, Bret, Schaffer, Ashleigh, Ho, Lingling, Robertson, Gail A., Ganetzky, Barry

“…To signal properly, excitable cells must establish and maintain the correct balance of various types of ion channels that increase or decrease membrane…”
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hERG Function in Light of Structure by Robertson, Gail A., Morais-Cabral, João H.

“…The human ether-a-go-go-related gene1 (hERG) ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than…”
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It's not funny: How changes in If limit maximum heart rate with aging by Robertson, Gail A

“…Robertson highlights recent work showing how aging limits pacemaking by the funny current, If, in the sinoatrial node…”
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Being Black in biophysics by Robertson, Gail A., Clemons, William M., Griffith, Theanne N.

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