Search Results - "Robertson, GS"

Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination by Hebb, ALO, Moore, CS, Bhan, V, Campbell, T, Fisk, JD, Robertson, HA, Thorne, M, Lacasse, E, Holcik, M, Gillard, J, Crocker, SJ, Robertson, GS

“…A failure of autoreactive T cells to undergo apoptosis may contribute to the pathogenesis of multiple sclerosis (MS). The role of the inhibitor of apoptosis…”
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Effects of sea temperature and stratification changes on seabird breeding success by Carroll, M. J., Butler, A., Owen, E., Ewing, S. R., Cole, T., Green, J. A., Soanes, L. M., Arnould, J. P. Y., Newton, S. F., Baer, J., Daunt, F., Wanless, S., Newell, M. A., Robertson, G. S., Mavor, R. A., Bolton, M.

“…As apex predators in marine ecosystems, seabirds may primarily experience climate change impacts indirectly, via changes to their food webs. Observed seabird…”
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Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane by Wang, H, Murphy, R, Taaffe, D, Yin, S, Xia, L, Hauswirth, W W, Bance, M, Robertson, G S, Wang, J

“…The auditory portion of the inner ear, the cochlea, is an ideal organ for local gene transfection owing to its relative isolation. Various carriers have been…”
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Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation by Gervais, François G., Xu, Daigen, Robertson, George S., Vaillancourt, John P., Zhu, Yanxia, Huang, JingQi, LeBlanc, Andréa, Smith, David, Rigby, Michael, Shearman, Mark S., Clarke, Earl E., Zheng, Hui, Van Der Ploeg, Leonardus H.T., Ruffolo, Salvatore C., Thornberry, Nancy A., Xanthoudakis, Steve, Zamboni, Robert J., Roy, Sophie, Nicholson, Donald W.

“…The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation…”
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Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease by Crocker, Stephen J, Smith, Patrice D, Jackson-Lewis, Vernice, Lamba, Wiplore R, Hayley, Shawn P, Grimm, Erich, Callaghan, Steve M, Slack, Ruth S, Melloni, Edon, Przedborski, Serge, Robertson, George S, Anisman, Hymie, Merali, Zul, Park, David S

“…The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood. Here, we provide evidence to…”
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Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates by Borisoff, Jaimie F, Chan, Carmen C.M, Hiebert, Gordon W, Oschipok, Loren, Robertson, George S, Zamboni, R, Steeves, John D, Tetzlaff, Wolfram

“…Several molecules inhibit axonal growth cones and may account for the failure of central nervous system regeneration, including myelin proteins and various…”
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Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons by Cregan, Sean P, MacLaurin, Jason G, Craig, Constance G, Robertson, George S, Nicholson, Donald W, Park, David S, Slack, Ruth S

“…p53 is a pivotal molecule regulating the death of neurons both after acute injury and during development. The molecular mechanisms by which p53 induces…”
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Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury by Han, Byung Hee, Xu, Daigen, Choi, Junjeong, Han, Yongxin, Xanthoudakis, Steven, Roy, Sophie, Tam, John, Vaillancourt, John, Colucci, John, Siman, Robert, Giroux, Andre, Robertson, George S., Zamboni, Robert, Nicholson, Donald W., Holtzman, David M.

“…Hypoxia-ischemia (H-I) in the developing brain results in brain injury with prominent features of both apoptosis and necrosis. A peptide-based pan-caspase…”
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Neuroprotection by the Inhibition of Apoptosis by Robertson, George S., Crocker, Stephen J., Nicholson, Donald W., Schulz, Jörg B.

“…Accumulating evidence strongly suggests that apoptosis contributes to neuronal cell death in a variety of neurodegenerative contexts. Activation of the…”
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E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3 by Giovanni, Andrew, Keramaris, Elizabeth, Morris, Erick J., Hou, Sheng T., O'Hare, Michael, Dyson, Nick, Robertson, George S., Slack, Ruth S., Park, David S.

“…Although B-amyloid (AB) is suggested to play an important role in Alzheimer's disease, the mechanisms that control AB-evoked toxicity are unclear. We…”
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Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat by Davoli, M.A, Fourtounis, J, Tam, J, Xanthoudakis, S, Nicholson, D, Robertson, G.S, Ng, G.Y.K, Xu, D

“…In the present study, we evaluated the time-course of caspase-3 activation, and the evolution of cell death following focal cerebral ischemia produced by…”
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Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity by Robertson, G S, Matsumura, H, Fibiger, H C

“…Clozapine and haloperidol produce different induction patterns of c-fos expression in the forebrain, with haloperidol increasing Fos-like immunoreactivity…”
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Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus by Xu, Daigen, Bureau, Yves, McIntyre, Dan C, Nicholson, Donald W, Liston, Peter, Zhu, Yanxia, Fong, Wei Gin, Crocker, Stephen J, Korneluk, Robert G, Robertson, George S

“…Transient forebrain ischemia produced by four-vessel occlusion (4-VO) triggers the delayed death of CA1 neurons in the hippocampus, resulting in behavioral…”
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Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine by Robertson, G S, Fibiger, H C

“…The mechanisms by which the atypical neuroleptic clozapine produces its therapeutic effects in the treatment of schizophrenia without causing the…”
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D 1 and D 2 dopamine receptors differentially increase fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain by Robertson, G.S., Jian, M.

“…Alterations in dopaminergic neurotransmission have profound effects on neuronal expression of the putative activity marker, Fos, in both the dorsal and ventral…”
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Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening by Foloppe, Nicolas, Fisher, Lisa M., Howes, Rob, Potter, Andrew, Robertson, Alan G.S., Surgenor, Allan E.

“…Chk1 structure → virtual screening → binding assay → compound QC → diverse new ligands → crystallography. Inhibition of the Chk1 kinase by small molecules is…”
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Neuroprotective effects of M826, a reversible caspase‐3 inhibitor, in the rat malonate model of Huntington's disease by Toulmond, Sylvie, Tang, Keith, Bureau, Yves, Ashdown, Helen, Degen, Sarah, O'Donnell, Ruth, Tam, John, Han, Yongxin, Colucci, John, Giroux, André, Zhu, Yanxia, Boucher, Mathieu, Pikounis, Bill, Xanthoudakis, Steven, Roy, Sophie, Rigby, Michael, Zamboni, Robert, Robertson, George S, Ng, Gordon Y K, Nicholson, Donald W, Flückiger, Jean‐Pierre

“…Caspases, key enzymes in the apoptosis pathway, have been detected in the brain of HD patients and in animal models of the disease. In the present study, we…”
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Schizophrenia : an integrative approach to modelling a complex disorder by ROBERTSON, George S, HORI, Sarah E, POWELL, Kelly J

“…The discovery of candidate susceptibility genes for schizophrenia and the generation of mice lacking proteins that reproduce biochemical processes that are…”
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Effects of minocycline and tetracycline on retinal ganglion cell survival after axotomy by Baptiste, D.C., Powell, K.J., Jollimore, C.A.B., Hamilton, C., Levatte, T.L., Archibald, M.L., Chauhan, B.C., Robertson, G.S., Kelly, M.E.M.

“…In the present study, we compared the in vivo neuroprotective efficacy of intraperitoneally administered tetracycline and minocycline to enhance the survival…”
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Dopamine-receptor stimulation: biobehavioral and biochemical consequences by Calon, Frédéric, Tahar, Abdallah Hadj, Blanchet, Pierre J., Morissette, Marc, Grondin, Richard, Goulet, Martin, Doucet, Jean-Pierre, Robertson, George S., Nestler, Eric, Di Paolo, Thérèse, Bédard, Paul J.

“…The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like…”
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