Search Results - "Robertson, Elizabeth J"

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo by Robertson, Elizabeth J, Arnold, Sebastian J

“…Key Points During development, cells become progressively restricted in their lineage choices. The allocation of cells to a specific lineage is regulated by…”
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Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain by Vasistha, Navneet A, García-Moreno, Fernando, Arora, Siddharth, Cheung, Amanda F P, Arnold, Sebastian J, Robertson, Elizabeth J, Molnár, Zoltán

“…The individual contribution of different progenitor subtypes towards the mature rodent cerebral cortex is not fully understood. Intermediate progenitor cells…”
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Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Growth and survival of the mammalian embryo within the uterine environment depends on the placenta, a highly complex vascularized organ comprised of both…”
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The Nodal Precursor Acting via Activin Receptors Induces Mesoderm by Maintaining a Source of Its Convertases and BMP4 by Ben-Haim, Nadav, Lu, Cindy, Guzman-Ayala, Marcela, Pescatore, Luca, Mesnard, Daniel, Bischofberger, Mirko, Naef, Felix, Robertson, Elizabeth J., Constam, Daniel B.

“…During early mouse development, the subtilisin-like proprotein convertases (SPC) Furin and PACE4 pattern the primitive ectoderm and visceral endoderm,…”
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Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse by Senft, Anna D., Bikoff, Elizabeth K., Robertson, Elizabeth J., Costello, Ita

“…The essential roles played by Nodal and Bmp signalling during early mouse development have been extensively documented. Here we use conditional deletion…”
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Pluripotency factors regulate definitive endoderm specification through eomesodermin by Teo, Adrian Kee Keong, Arnold, Sebastian J, Trotter, Matthew W B, Brown, Stephanie, Ang, Lay Teng, Chng, Zhenzhi, Robertson, Elizabeth J, Dunn, N Ray, Vallier, Ludovic

“…Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the…”
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transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes by Harper, James, Mould, Arne, Andrews, Robert M, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Female mammals produce milk to feed their newborn offspring before teeth develop and permit the consumption of solid food. Intestinal enterocytes dramatically…”
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Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, Salah, Morgan, Marc A., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly…”
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Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse by Arnold, Sebastian J, Hofmann, Ulf K, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The T-box transcription factor eomesodermin ( Eomes ) has been implicated as an important component in germ layer induction and patterning in vertebrate…”
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The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice by Goolam, Mubeen, Xypolita, Maria-Eleni, Costello, Ita, Lydon, John P., DeMayo, Francesco J., Bikoff, Elizabeth K., Robertson, Elizabeth J., Mould, Arne W.

“…The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional…”
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Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta by Mould, Arne, Morgan, Marc A J, Li, Li, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5) has been attributed to placental disturbances. Here we investigate…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation by Prall, Owen W.J., Menon, Mary K., Solloway, Mark J., Watanabe, Yusuke, Zaffran, Stéphane, Bajolle, Fanny, Biben, Christine, McBride, Jim J., Robertson, Bronwyn R., Chaulet, Hervé, Stennard, Fiona A., Wise, Natalie, Schaft, Daniel, Wolstein, Orit, Furtado, Milena B., Shiratori, Hidetaka, Chien, Kenneth R., Hamada, Hiroshi, Black, Brian L., Saga, Yumiko, Robertson, Elizabeth J., Buckingham, Margaret E., Harvey, Richard P.

“…During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now…”
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Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate…”
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Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice by Pangas, Stephanie A., Li, Xiaohui, Umans, Lieve, Zwijsen, An, Huylebroeck, Danny, Gutierrez, Carolina, Wang, Degang, Martin, James F., Jamin, Soazik P., Behringer, Richard R., Robertson, Elizabeth J., Matzuk, Martin M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Keeping a lid on nodal: transcriptional and translational repression of nodal signalling by Sampath, Karuna, Robertson, Elizabeth J.

“…Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to…”
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The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse by Vincent, Stéphane D, Dunn, N Ray, Sciammas, Roger, Shapiro-Shalef, Miriam, Davis, Mark M, Calame, Kathryn, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Blimp1, a zinc-finger containing DNA-binding transcriptional repressor, functions as a master regulator of B cell terminal differentiation. Considerable…”
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Nodal activity in the node governs left-right asymmetry by Brennan, Jane, Norris, Dominic P, Robertson, Elizabeth J

“…Nodal is expressed at the lateral edges of the mouse node, but its function in this "organizer" tissue remains unknown due to the early lethality of Nodal…”
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Dose-dependent Nodal/Smad signals pattern the early mouse embryo by Robertson, Elizabeth J.

“…•Nodal is a member of the TGFβ-superfamily of secreted growth factors.•Nodal signals in the early post-implantation stage embryo are essential to establish…”
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Loss of Endogenous Bone Morphogenetic Protein-6 Aggravates Renal Fibrosis by Dendooven, Amélie, van Oostrom, Olivia, van der Giezen, Dionne M, Willem Leeuwis, Jan, Snijckers, Cristel, Joles, Jaap A, Robertson, Elizabeth J, Verhaar, Marianne C, Nguyen, Tri Q, Goldschmeding, Roel

“…Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin. In…”
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