Search Results - "Roberts‐Thomson, S J"

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention by Azimi, I, Roberts‐Thomson, S J, Monteith, G R

“…Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle…”
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Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent by Davis, F M, Azimi, I, Faville, R A, Peters, A A, Jalink, K, Putney, J W, Goodhill, G J, Thompson, E W, Roberts-Thomson, S J, Monteith, G R

“…Signals from the tumor microenvironment trigger cancer cells to adopt an invasive phenotype through epithelial–mesenchymal transition (EMT). Relatively little…”
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Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells by Jamaludin, S Y N, Azimi, I, Davis, F M, Peters, A A, Gonda, T J, Thompson, E W, Roberts-Thomson, S J, Monteith, G R

“…CXC ligand (L)12 is a chemokine implicated in the migration, invasion and metastasis of cancer cells via interaction with its receptors CXC chemokine receptor…”
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Neuro-Oncology and Radiogenomics: Time to Integrate? by Lasocki, A, Rosenthal, M A, Roberts-Thomson, S J, Neal, A, Drummond, K J

“…Radiogenomics aims to predict genetic markers based on imaging features. The critical importance of molecular markers in the diagnosis and management of…”
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Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells by Peters, A A, Jamaludin, S Y N, Yapa, K T D S, Chalmers, S, Wiegmans, A P, Lim, H F, Milevskiy, M J G, Azimi, I, Davis, F M, Northwood, K S, Pera, E, Marcial, D L, Dray, E, Waterhouse, N J, Cabot, P J, Gonda, T J, Kenny, P A, Brown, M A, Khanna, K K, Roberts-Thomson, S J, Monteith, G R

“…The critical role of calcium signalling in processes related to cancer cell proliferation and invasion has seen a focus on pharmacological inhibition of…”
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Peroxisome proliferator-activated receptors in tumorigenesis: Targets of tumour promotion and treatment by Roberts‐Thomson, Sarah J

“…The peroxisome proliferator‐activated receptors (PPAR) are ligand‐activated transcription factors. There are three genes that code for the PPAR isoforms:…”
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Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines by Lee, Won Jae, Roberts-Thomson, Sarah J., Monteith, Gregory R.

“…There is evidence to suggest that plasma membrane Ca 2+-ATPase (PMCA) isoforms are important mediators sssof mammary gland physiology. PMCA2 in particular is…”
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Mammary gland carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets by Snyderwine, E.G, Thorgeirsson, U.P, Venugopal, M, Roberts-Thomson, S.J

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic amine derived from cooked meat. Mammary gland tumors were induced in…”
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Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet by SNYDERWINE, E. G, DAVIS, C. D, SCHUT, H. A. J, ROBERTS-THOMSON, S. J

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine derived from cooked meat that is a mammary gland carcinogen in rats. A…”
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Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues by McKinnon, R A, Burgess, W M, Hall, P M, Roberts-Thomson, S J, Gonzalez, F J, McManus, M E

“…The human CYP3A subfamily is of interest due to its multiplicity, activity toward known carcinogens, and extrahepatic expression. In situ hybridisation…”
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Development of a real-time RT-PCR assay for plasma membrane calcium ATPase isoform 1 (PMCA1) mRNA levels in a human breast epithelial cell line by Roberts-Thomson, S.J, Holman, N.A, May, F.J, Lee, W.-J, Monteith, G.R

“…The plasma membrane Ca 2+ pump is a key regulator of cytosolic free Ca 2+. Recent studies have demonstrated the dynamic expression of the plasma membrane Ca 2+…”
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Characterization of peroxisome proliferator-activated receptor alpha in normal rat mammary gland and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets by ROBERTS-THOMSON, Sarah J, SNYDERWINE, Elizabeth G

“…Normal Sprague-Dawley rat mammary gland epithelial cells and mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen…”
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Activation of the peroxisome proliferator-activated receptor-α enhances cell death in cultured cerebellar granule cells by Smith, Steven A., May, Fiona J., Monteith, Gregory R., Roberts-Thomson, Sarah J.

“…Peroxisome proliferator‐activated receptor‐α (PPARα) is a member of the steroid hormone receptor superfamily. In rodents, PPARα alters genes involved in cell…”
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The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen by Roberts-Thomson, S J, McManus, M E, Tukey, R H, Gonzalez, F F, Holder, G M

“…The catalytic properties of expressed human cytochromes P4501A1, 1A2, 3A4 and 3A5 with respect to the metabolite distribution for the carcinogen benzo[a]pyrene…”
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mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors by ROBERTS-THOMSON, S. J, SNYDERWINE, E. G

“…The mRNA differential display technique was used to compare mRNAs between normal mammary gland and tumor-derived epithelial cells from female Sprague-Dawley…”
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PMCA1 mRNA Expression in Rat Aortic Myocytes: A Real-Time RT–PCR Study by Mamic, Tanya M., Holman, Nicola A., Roberts-Thomson, Sarah J., Monteith, Gregory R.

“…The plasmalemmal Ca2+ adenosine triphosphatase (PMCA) is a key regulator of Ca2+ efflux in vascular smooth muscle. In these studies we developed a real-time…”
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Metabolism of polycyclic aza-aromatic carcinogens catalyzed by four expressed human cytochromes P450 by ROBERTS-THOMSON, S. J, MCMANUS, M. E, TUKEY, R. H, GONZALEZ, F. J, HOLDER, G. M

“…The role of human cytochromes P4501A1, -1A2, -3A4, and -3A5 in the metabolism of the polycyclic aza-aromatic hydrocarbons 7-methylbenz(c)acridine and…”
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Effect of dietary fat on codon 12 and 13 Ha-ras gene mutations in 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine-induced rat mammary gland tumors by Roberts-Thomson, Sarah J., Snyderwine, Elizabeth G.

“…Activating mutations in and expression of the Ha‐ras gene were examined in benign and malignant female Sprague‐Dawley rat mammary gland tumors induced by the…”
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Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation by Azimi, Iman, Bong, Alice H., Poo, Greta X. H., Armitage, Kaela, Lok, Dawn, Roberts-Thomson, Sarah J., Monteith, Gregory R.

“…Store-operated Ca 2+ entry is a pathway that is remodelled in a variety of cancers, and altered expression of the components of store-operated Ca 2+ entry is a…”
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Abstract P2-05-08: An assessment of the potential role of intracellular Ca2+ store regulators in breast cancer cells by Bong, AH, Roberts-Thomson, SJ, Milevskiy, MJ, Monteith, GR

“…Abstract Background: Calcium (Ca2+) regulates many crucial cellular processes including cell survival, proliferation and death. Endoplasmic reticulum (ER) Ca2+…”
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