Search Results - "Roberts, Sue A."

Rational reprogramming of fungal polyketide first-ring cyclization by Xu, Yuquan, Zhou, Tong, Zhou, Zhengfu, Su, Shiyou, Roberts, Sue A., Montfort, William R., Zeng, Jia, Chen, Ming, Zhang, Wei, Lin, Min, Zhan, Jixun, Molnár, István

“…Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores with heat shock response and immune system modulatory…”
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Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders by Lajoie, Daniel M., Roberts, Sue A., Zobel-Thropp, Pamela A., Delahaye, Jared L., Bandarian, Vahe, Binford, Greta J., Cordes, Matthew H.J.

“…Venoms of the sicariid spiders contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans. These enzymes convert…”
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Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily by Miles, Zachary D., Roberts, Sue A., McCarty, Reid M., Bandarian, Vahe

“…6-Pyruvoyltetrahydropterin synthase (PTPS) homologs in both mammals and bacteria catalyze distinct reactions using the same 7,8-dihydroneopterin triphosphate…”
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Crystal Structure and Electron Transfer Kinetics of CueO, A Multicopper Oxidase Required for Copper Homeostasis in Escherichia coli by Roberts, Sue A., Weichsel, Andrzej, Grass, Gregor, Thakali, Keshari, Hazzard, James T., Tollin, Gordon, Rensing, Christopher, Montfort, William R.

“…CueO (YacK), a multicopper oxidase, is part of the copper-regulatory cue operon in Escherichia coli. The crystal structure of CueO has been determined to 1.4-Å…”
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Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds by Roessler, Christian G, Hall, Branwen M, Anderson, William J, Ingram, Wendy M, Roberts, Sue A, Montfort, William R, Cordes, Matthew H.J

“…Proteins that share common ancestry may differ in structure and function because of divergent evolution of their amino acid sequences. For a typical diverse…”
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A Labile Regulatory Copper Ion Lies Near the T1 Copper Site in the Multicopper Oxidase CueO by Roberts, Sue A., Wildner, Günter F., Grass, Gregor, Weichsel, Andrzej, Ambrus, Attila, Rensing, Christopher, Montfort, William R.

“…CueO, a multicopper oxidase, is part of the copper-regulatory cue operon in Escherichia coli, is expressed under conditions of copper stress and shows enhanced…”
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Allostery in Recombinant Soluble Guanylyl Cyclase from Manduca sexta by Hu, Xiaohui, Murata, Lauren B., Weichsel, Andrzej, Brailey, Jacqueline L., Roberts, Sue A., Nighorn, Alan, Montfort, William R.

“…Soluble guanylyl/guanylate cyclase (sGC), the primary biological receptor for nitric oxide, is required for proper development and health in all animals. We…”
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Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle by Jayakanthan, Samuel, Roberts, Sue A, Weichsel, Andrzej, Argüello, José M, McEvoy, Megan M

“…Heavy metal P1B-type ATPases play a critical role in cell survival by maintaining appropriate intracellular metal concentrations. Archaeoglobus fulgidus CopB…”
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3-(4-Bromo-phen-yl)-1-butyl-5-[1-(2-chloro-6-methyl-phen-yl)-1H-tetra-zol-5-yl]imidazolidine-2,4-dione by Hall, Gabriel B, Medda, Federico, Roberts, Sue A, Hulme, Christopher

“…In the title mol-ecule, C21H20BrClN6O2, the chloro-substituted benzene ring forms a dihedral angle of 77.84 (7)° with the tetra-zole ring and the…”
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(Z)‑Stereoselective Synthesis of Mono- and Bis-heterocyclic Benzimidazol-2-ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction by Xu, Zhigang, Martinez-Ariza, Guillermo, Cappelli, Alexandra P, Roberts, Sue A, Hulme, Christopher

“…Several novel cascade reactions are herein reported that enable access to a variety of unique mono- and bis-heterocyclic scaffolds. The sequence of cascade…”
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Extreme divergence between one-to-one orthologs: the structure of N15 Cro bound to operator DNA and its relationship to the λ Cro complex by Hall, Branwen M, Roberts, Sue A, Cordes, Matthew H J

“…The gene cro promotes lytic growth of phages through binding of Cro protein dimers to regulatory DNA sites. Most Cro proteins are one-to-one orthologs, yet…”
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Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence by Singh, Satish K, Roberts, Sue A, McDevitt, Sylvia F, Weichsel, Andrzej, Wildner, Guenter F, Grass, Gregor B, Rensing, Christopher, Montfort, William R

“…The multicopper oxidase CueO oxidizes toxic Cu(I) and is required for copper homeostasis in Escherichia coli. Like many proteins involved in copper…”
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Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X‑ray Scattering and Chemical Cross-Linking by Fritz, Bradley G, Roberts, Sue A, Ahmed, Aqeel, Breci, Linda, Li, Wenzhou, Weichsel, Andrzej, Brailey, Jacqueline L, Wysocki, Vicki H, Tama, Florence, Montfort, William R

“…Soluble guanylyl/guanylate cyclase (sGC) converts GTP to cGMP after binding nitric oxide, leading to smooth muscle relaxation and vasodilation. Impaired sGC…”
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The Synthesis of Stable, Complex Organocesium Tetramic Acids through the Ugi Reaction and Cesium-Carbonate-Promoted Cascades by Martinez-Ariza, Guillermo, Ayaz, Muhammad, Roberts, Sue A., Rabanal-León, Walter A., Arratia-Pérez, Ramiro, Hulme, Christopher

“…Two structurally unique organocesium carbanionic tetramic acids have been synthesized through expeditious and novel cascade reactions of strategically…”
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A Novel Copper-Binding Fold for the Periplasmic Copper Resistance Protein CusF by Loftin, Isabell R, Franke, Sylvia, Roberts, Sue A, Weichsel, Andrzej, Héroux, Annie, Montfort, William R, Rensing, Christopher, McEvoy, Megan M

“…We have determined the crystal structure of apo-CusF, a periplasmic protein involved in copper and silver resistance in Escherichia coli. The protein forms a…”
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Ultrahigh Resolution Structures of Nitrophorin 4:  Heme Distortion in Ferrous CO and NO Complexes by Maes, Estelle M, Roberts, Sue A, Weichsel, Andrzej, Montfort, William R

“…Nitrophorin 4 (NP4), a nitric oxide (NO)-transport protein from the blood-sucking insect Rhodnius prolixus, uses a ferric (Fe3+) heme to deliver NO to its…”
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Phospholipase D toxins from spiders, bacteria, and fungi generate cyclic phosphate products by Lajoie, Daniel M., Zobel-Thropp, Pamela A., Delahaye, Jared L., Roberts, Sue A., Bandarian, Vahe, Binford, Greta J., Cordes, Matthew H.J.

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Improved Synthesis of 10-(2-Alkylamino-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid Derivatives Bearing Acid-Sensitive Linkers by Jagadish, Bhumasamudram, Ozumerzifon, Tarik J., Roberts, Sue A., Hall, Gabriel B., Mash, Eugene A., Raghunand, Natarajan

“…Alkylation of the hydrobromide salts of 1,4,7-tris(methoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane and…”
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Crystal structures of N - tert -butyl-3-(4-fluorophenyl)-5-oxo-4-[2-(trifluoromethoxy)phenyl]-2,5-dihydrofuran-2-carboxamide and 4-(2 H -1,3-benzodioxol-5-yl)- N -cyclohexyl-5-oxo-3-[4-(trifluoromethyl)phenyl]-2,5-dihydrofuran-2-carboxamide by Roberts, Sue A., Martinez-Ariza, Guillermo, Hulme, Christopher

“…The title compounds, C 22 H 19 F 4 NO 4 , (I), and C 25 H 22 F 3 NO 5 , (II), each contain a central nearly planar dihydrofuranone ring. The r.m.s. deviation…”
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Protein Functional Cycle Viewed at Atomic Resolution:  Conformational Change and Mobility in Nitrophorin 4 as a Function of pH and NO Binding by Kondrashov, Dmitry A, Roberts, Sue A, Weichsel, Andrzej, Montfort, William R

“…The blood-sucking insect Rhodnius prolixus uses nitrophorin 4, a heme protein, to deliver nitric oxide (NO) to a victim, causing vasodilation and improved…”
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