Search Results - "Roberts, Ruth R.A"

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    Gender differences in drug toxicity by Nicolson, Tamara J, Mellor, Howard R, Roberts, Ruth R.A

    “…Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis…”
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    Journal Article
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    Cardiotoxicity associated with targeting kinase pathways in cancer by Mellor, Howard R, Bell, Alex R, Valentin, Jean-Pierre, Roberts, Ruth R A

    Published in Toxicological sciences (01-03-2011)
    “…Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with the use of some small-molecule kinase inhibitors and…”
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    Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors by Anderton, Mark J., Mellor, Howard R., Bell, Alex, Sadler, Claire, Pass, Martin, Powell, Steve, Steele, Samantha J., Roberts, Ruth. R. A., Heier, Annabelle

    Published in Toxicologic pathology (01-10-2011)
    “…Aberrant signaling by transforming growth factor-β (TGF-β) and its type I (ALK5) receptor has been implicated in a number of human diseases and this pathway is…”
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    Journal Article