Search Results - "Roberts, Ruth"

Understanding drug targets: no such thing as bad news by Roberts, Ruth A.

“…•Safety issues related to target biology remain one of the major reasons for drug project failure.•Assessment of the likely unintended consequences of hitting…”
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AI-based language models powering drug discovery and development by Liu, Zhichao, Roberts, Ruth A., Lal-Nag, Madhu, Chen, Xi, Huang, Ruili, Tong, Weida

“…•AI-powered Language models are promising in drug discovery and development.•A ‘fit-for-purpose’ selection the key to positioning AI-powered language models in…”
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Gender differences in drug toxicity by Nicolson, Tamara J, Mellor, Howard R, Roberts, Ruth R.A

“…Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis…”
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Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors by Anderton, Mark J., Mellor, Howard R., Bell, Alex, Sadler, Claire, Pass, Martin, Powell, Steve, Steele, Samantha J., Roberts, Ruth. R. A., Heier, Annabelle

“…Aberrant signaling by transforming growth factor-β (TGF-β) and its type I (ALK5) receptor has been implicated in a number of human diseases and this pathway is…”
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Cardiotoxicity associated with targeting kinase pathways in cancer by Mellor, Howard R, Bell, Alex R, Valentin, Jean-Pierre, Roberts, Ruth R A

“…Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with the use of some small-molecule kinase inhibitors and…”
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A generative adversarial network model alternative to animal studies for clinical pathology assessment by Chen, Xi, Roberts, Ruth, Liu, Zhichao, Tong, Weida

“…Animal studies are unavoidable in evaluating chemical and drug safety. Generative Adversarial Networks (GANs) can generate synthetic animal data by learning…”
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Generation of a drug-induced renal injury list to facilitate the development of new approach methodologies for nephrotoxicity by Connor, Skylar, Li, Ting, Qu, Yanyan, Roberts, Ruth A, Tong, Weida

“…•There is a pressing need for alternative methods to detect drug-induced renal injury earlier.•We created DIRIL (drug-induced renal injury list) from existing…”
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Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity by Rusyn, Ivan, Arzuaga, Xabier, Cattley, Russell C., Corton, J. Christopher, Ferguson, Stephen S., Godoy, Patricio, Guyton, Kathryn Z., Kaplowitz, Neil, Khetani, Salman R., Roberts, Ruth A., Roth, Robert A., Smith, Martyn T.

“…Hazard identification regarding adverse effects on the liver is a critical step in safety evaluations of drugs and other chemicals. Current testing paradigms…”
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Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity by Thakkar, Shraddha, Li, Ting, Liu, Zhichao, Wu, Leihong, Roberts, Ruth, Tong, Weida

“…[Display omitted] •This drug list provides access to the largest number of drugs classified for human hepatotoxicity.•DILIst (DILI severity and toxicity) is…”
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Drug-induced kidney injury: challenges and opportunities by Connor, Skylar, Roberts, Ruth A, Tong, Weida

“…Drug-induced kidney injury (DIKI) is a frequently reported adverse event, associated with acute kidney injury, chronic kidney disease, and end-stage renal…”
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Towards accurate and reliable resolution of structural variants for clinical diagnosis by Liu, Zhichao, Roberts, Ruth, Mercer, Timothy R, Xu, Joshua, Sedlazeck, Fritz J, Tong, Weida

“…Structural variants (SVs) are a major source of human genetic diversity and have been associated with different diseases and phenotypes. The detection of SVs…”
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Data science in drug discovery safety: Challenges and opportunities by Coltman, Nicholas J, Roberts, Ruth A, Sidaway, James E

“…Early de-risking of drug targets and chemistry is essential to provide drug projects with the best chance of success. Target safety assessments (TSAs) use…”
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Computational drug repositioning for rare diseases in the era of precision medicine by Delavan, Brian, Roberts, Ruth, Huang, Ruili, Bao, Wenjun, Tong, Weida, Liu, Zhichao

“…•Next-generation sequencing technology accelerates rare disease research.•Accumulated genomics information aids orphan drug development.•Novel drug…”
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Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration by Walker, Abigail L, Imam, Syed Z, Roberts, Ruth A

“…The discovery and development of new drugs are vital if we are to improve and expand treatment options available to improve outcomes for patients. Overall,…”
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Academic drug discovery: Challenges and opportunities by Murray, Angela J., Cox, Liam R., Adcock, Holly V., Roberts, Ruth A.

“…•Academic drug discovery offers great opportunities but has challenges in prioritisation and funding.•We describe a paradigm for academic drug discovery with…”
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Mental health service use by young people: the role of caregiver characteristics by Gronholm, Petra C, Ford, Tamsin, Roberts, Ruth E, Thornicroft, Graham, Laurens, Kristin R, Evans-Lacko, Sara

“…Many children and adolescents experiencing mental health problems do not receive appropriate care. Strategies to encourage appropriate access to services might…”
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Adolescent trajectories of fine motor and coordination skills and risk for schizophrenia by Dickson, Hannah, Roberts, Ruth E., To, Melody, Wild, Kate, Loh, Max, Laurens, Kristin R.

“…Premorbid motor dysfunction is one of the earliest of developmental antecedents identified among individuals who develop schizophrenia in adulthood. However,…”
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Drug-Induced Oxidative Stress and Toxicity by Deavall, Damian G., Martin, Elizabeth A., Horner, Judith M., Roberts, Ruth

“…Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and…”
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Nitrative and Oxidative Stress in Toxicology and Disease by Roberts, Ruth A., Laskin, Debra L., Smith, Charles V., Robertson, Fredika M., Allen, Erin M. G., Doorn, Jonathan A., Slikker, William

“…Persistent inflammation and the generation of reactive oxygen and nitrogen species play pivotal roles in tissue injury during disease pathogenesis and as a…”
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Toxicological and pathophysiological roles of reactive oxygen and nitrogen species by Roberts, Ruth A, Smith, Robert A, Safe, Stephen, Szabo, Csaba, Tjalkens, Ronald B, Robertson, Fredika M

“…Abstract ‘ Oxidative and Nitrative Stress in Toxicology and Disease ’ was the subject of a symposium held at the EUROTOX meeting in Dresden 15th September…”
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