Search Results - "Roberts, Irene A. G"

Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy by O'Donoghue, Keelin, Chan, Jerry, de la Fuente, Josu, Kennea, Nigel, Sandison, Ann, Anderson, Jonathan R, Roberts, Irene AG, Fisk, Nicholas M

“…Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. The frequency of subsequent fetomaternal microchimerism in…”
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Activated invariant NKT cells regulate osteoclast development and function by Hu, Ming, Bassett, J H Duncan, Danks, Lynett, Howell, Peter G T, Xu, Ke, Spanoudakis, Emmanouil, Kotsianidis, Ioannis, Boyde, Alan, Williams, Graham R, Horwood, Nikki, Roberts, Irene A G, Karadimitris, Anastasios

“…Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced…”
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Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma by Alvarez-Benayas, Jaime, Trasanidis, Nikolaos, Katsarou, Alexia, Ponnusamy, Kanagaraju, Chaidos, Aristeidis, May, Philippa C., Xiao, Xiaolin, Bua, Marco, Atta, Maria, Roberts, Irene A. G., Auner, Holger W., Hatjiharissi, Evdoxia, Papaioannou, Maria, Caputo, Valentina S., Sudbery, Ian M., Karadimitris, Anastasios

“…Multiple myeloma is a genetically heterogeneous cancer of the bone marrow plasma cells (PC). Distinct myeloma transcriptome profiles are primarily driven by…”
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Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow by Campagnoli, Cesare, Roberts, Irene A.G., Kumar, Sailesh, Bennett, Phillip R., Bellantuono, Ilaria, Fisk, Nicholas M.

“…Human mesenchymal stem/progenitor cells (MSCs) have been identified in adult bone marrow, but little is known about their presence during fetal life. MSCs were…”
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Can routine commercial cord blood banking be scientifically and ethically justified? by Fisk, Nicholas M, Roberts, Irene A G, Markwald, Roger, Mironov, Vladimir

“…Umbilical cord blood--the blood that remains in the placenta after birth--can be collected and stored frozen for years. A well-accepted use of cord blood is as…”
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Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells by Kotsianidis, Ioannis, Silk, Jonathan D., Spanoudakis, Emmanouil, Patterson, Scott, Almeida, Antonio, Schmidt, Richard R., Tsatalas, Costas, Bourikas, George, Cerundolo, Vincenzo, Roberts, Irene A.G., Karadimitris, Anastasios

“…Invariant natural killer T cells (iNKT cells) are a small subset of immunoregulatory T cells highly conserved in humans and mice. On activation by glycolipids…”
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The role of hydroxyurea in sickle cell disease by Halsey, Christina, Roberts, Irene A. G.

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Human Invariant NKT Cells Are Required for Effective In Vitro Alloresponses by Patterson, Scott, Kotsianidis, Ioannis, Almeida, Antonio, Politou, Marianna, Rahemtulla, Amin, Matthew, Bini, Schmidt, Richard R, Cerundolo, Vincenzo, Roberts, Irene A. G, Karadimitris, Anastasios

“…NKT cells are a small subset of regulatory T cells conserved in humans and mice. In humans they express the Valpha24Jalpha18 invariant chain (hence invariant…”
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Human Invariant NKT Cells Display Alloreactivity Instructed by Invariant TCR-CD1d Interaction and Killer Ig Receptors by Patterson, Scott, Chaidos, Aristeidis, Neville, David C. A, Poggi, Alessandro, Butters, Terry D, Roberts, Irene A. G, Karadimitris, Anastasios

“…Invariant NKT (iNKT) cells are a subset of highly conserved immunoregulatory T cells that modify a variety of immune responses, including alloreactivity…”
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Stem cell transplantation for chronic myeloid leukemia in children by Cwynarski, Kate, Roberts, IreneA.G., Iacobelli, Simona, van Biezen, Anja, Brand, Ronald, Devergie, Agnes, Vossen, Jaak M., Aljurf, Mahmoud, Arcese, William, Locatelli, Franco, Dini, Giorgio, Niethammer, Dietrich, Niederwieser, Dietger, Apperley, Jane F.

“…Hematopoietic stem cell transplantation (SCT) is the only proven cure for chronic myeloid leukemia (CML), a rare disease in childhood. We report outcomes of…”
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Bone marrow transplantation for β‐thalassaemia major: the UK experience in two paediatric centres by Lawson, Sarah E., Roberts, Irene A. G., Amrolia, Persis, Dokal, Inderjeet, Szydlo, Richard, Darbyshire, Philip J.

“…Stem cell transplantation (SCT) remains the only cure for thalassaemia major. Recent advances in medical treatment make it even more important that accurate…”
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Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma by Trasanidis, Nikolaos, Katsarou, Alexia, Ponnusamy, Kanagaraju, Shen, Yao-An, Kostopoulos, Ioannis V., Bergonia, Bien, Keren, Keren, Reema, Paudel, Xiao, Xiaolin, Szydlo, Richard M., Sabbattini, Pierangela M.R., Roberts, Irene A.G., Auner, Holger W., Naresh, Kikkeri N., Chaidos, Aristeidis, Wang, Tian-Li, Magnani, Luca, Caputo, Valentina S., Karadimitris, Anastasios

“…Understanding the biological and clinical impact of copy number aberrations (CNAs) on the development of precision therapies in cancer remains an unmet…”
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Therapeutic challenges in childhood sickle cell disease Part 1: current and future treatment options by Amrolia, Persis J., Almeida, Antonio, Halsey, Christina, Roberts, Irene A. G., Davies, Sally C.

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High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans by Roy, Anindita, Bystry, Vojtech, Bohn, Georg, Goudevenou, Katerina, Reigl, Tomas, Papaioannou, Maria, Krejci, Adam, O'Byrne, Sorcha, Chaidos, Aristeidis, Grioni, Andrea, Darzentas, Nikos, Roberts, Irene A.G., Karadimitris, Anastasios

“…The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated)…”
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Haemolytic disease of the newborn by Murray, Neil A, Roberts, Irene A G

“…Table 1 Causes of haemolytic disease of the newborn presenting as early-onset or rapidly progressive hyperbilirubinaemia not predicted by maternal antibody…”
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Targeted Therapy for Inherited GPI Deficiency by Almeida, Antonio M, Murakami, Yoshiko, Baker, Alastair, Maeda, Yusuke, Roberts, Irene A.G, Kinoshita, Taroh, Layton, D. Mark, Karadimitris, Anastasios

“…Inherited glycosylphosphatidylinositol (GPI) deficiency, characterized by splanchnic vein thrombosis and epilepsy, is caused by a mutation in the promoter…”
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PNH cells are as sensitive to T-cell-mediated lysis as their normal counterparts : implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria by KARADIMITRIS, Anastasios, NOTARO, Rosario, KOEHNE, Gunther, ROBERTS, Irene A. G, LUZZATTO, Lucio

“…The mechanism responsible for the bone marrow failure that is almost invariable in paroxysmal nocturnal haemoglobinuria (PNH) is unknown. Based on the close…”
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Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency by Costa, Joana R., Caputo, Valentina S., Makarona, Kalliopi, Layton, D. Mark, Irene Roberts, A.G., Almeida, Antonio M., Karadimitris, Anastasios

“…A rare point mutation in the core promoter −270GC-rich box of PIGM, a housekeeping gene, disrupts binding of the generic transcription factor (TF) Sp1 and…”
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The changing face of haemolytic disease of the newborn by Roberts, Irene A.G

“…Abstract The diagnosis, acute management and follow-up of neonates with haemolytic disease of the newborn (HDN) still represents a significant area of activity…”
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Expandability of haemopoietic progenitors in first trimester fetal and maternal blood: implications for non-invasive prenatal diagnosis by Campagnoli, Cesare, Roberts, Irene A. G., Kumar, Sailesh, Choolani, Mahesh, Bennett, Phillip R., Letsky, Elizabeth, Fisk, Nicholas M.

“…Objectives Selective amplification of rare fetal cells in maternal blood is a potential strategy for non‐invasive prenatal diagnosis. We assessed the…”
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