Search Results - "Roberts, Edda F"

Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat by Clemens, J A, Stephenson, D T, Smalstig, E B, Roberts, E F, Johnstone, E M, Sharp, J D, Little, S P, Kramer, R M

“…Phospholipid breakdown has been reported to be an early event in the brain after global cerebral ischemia. Our earlier observations showing the localization of…”
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator by Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.

“…A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold…”
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Thrombin Induces Activation of p38 MAP Kinase in Human Platelets by Kramer, R M, Roberts, E F, Strifler, B A, Johnstone, E M

“…In human platelets a proline-directed kinase distinct from the ERK MAP kinases is stimulated by both thrombin and the thrombin receptor agonist peptide SFLLRN…”
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Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats by SLIEKER, L. J, ROBERTS, E. F, SHAW, W. N, JOHNSON, W. T

“…We examined insulin binding, insulin-stimulated autophosphorylation, and phosphorylation of poly(Glu.Na,Tyr)4:1 by liver and skeletal muscle insulin receptor…”
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Differential Activation of Cytosolic Phospholipase A2 (cPLA2) by Thrombin and Thrombin Receptor Agonist Peptide in Human Platelets. EVIDENCE FOR ACTIVATION OF cPLA2 INDEPENDENT OF THE MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 by Kramer, Ruth M., Roberts, Edda F., Hyslop, Paul A., Utterback, Barbara G., Hui, Kwan Y., Jakubowski, Joseph A.

“…The thrombin receptor agonist peptide SFLLRN was less effective than thrombin in eliciting the liberation of arachidonic acid and the generation of thromboxane…”
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Derivation and characterization of a monoclonal antibody against human glycinamide ribonucleotide formyltransferase by Dotzlaf, Joe, Carpenter, John, Luo, Shuang, Roberts, Edda F, Solenberg, Patricia J, Qian, Yue-Wei, Lin, Aimin, He, Xiaohua, Sandusky, George E, McClure, Don B, Chen, Victor J, Zuckerman, Steven H

“…Glycinamide ribonucleotide formyltransferase (GARFT) is a trifunctional enzyme involved in purine biosynthesis. Its central role in folate metabolism has made…”
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p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets by Kramer, Ruth M., Roberts, Edda F., Um, Suzane L., Börsch-Haubold, Angelika G., Watson, Steve P., Fisher, Matthew J., Jakubowski, Joseph A.

“…The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of…”
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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2 by Kramer, R M, Roberts, E F, Um, S L, Börsch-Haubold, A G, Watson, S P, Fisher, M J, Jakubowski, J A

“…The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of…”
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Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets by Kramer, R M, Roberts, E F, Manetta, J V, Hyslop, P A, Jakubowski, J A

“…Receptor-mediated activation of human platelets by thrombin initiates a series of rapid biochemical events that include activation of phospholipase A2 to…”
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Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2 by Sharp, J D, White, D L, Chiou, X G, Goodson, T, Gamboa, G C, McClure, D, Burgett, S, Hoskins, J, Skatrud, P L, Sportsman, J R

“…Phospholipases A2 (PLA2s) play a key role in inflammatory processes through production of precursors of eicosanoids and platelet-activating factor. Recently,…”
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Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 by Sharp, J D, Pickard, R T, Chiou, X G, Manetta, J V, Kovacevic, S, Miller, J R, Varshavsky, A D, Roberts, E F, Strifler, B A, Brems, D N

“…The Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) displays both a phospholipase A2 and a lysophospholipase activity. Numerous hydrolases, including…”
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Activation of Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets by Kramer, R M, Roberts, E F, Jakubowski, J A

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Differential Activation of Cytosolic Phospholipase A (cPLA) by Thrombin and Thrombin Receptor Agonist Peptide in Human Platelets. EVIDENCE FOR ACTIVATION OF cPLA2 INDEPENDENT OF THE MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 by Ruth M. Kramer, Edda F. Roberts, Paul A. Hyslop, Barbara G. Utterback, Kwan Y. Hui, Joseph A. Jakubowski

“…The thrombin receptor agonist peptide SFLLRN was less effective than thrombin in eliciting the liberation of arachidonic acid and the generation of thromboxane…”
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Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain by Kramer, R M, Stephenson, D T, Roberts, E F, Clemens, J A

“…The Ca(2+)-sensitive 85 kDa cytosolic PLA2 (cPLA2) is a receptor-regulated enzyme that may initiate the cascade of events leading to the production of free…”
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Cytosolic phospholipase A 2 (cPLA 2) and lipid mediator release in the brain by Kramer, Ruth M., Stephenson, Diane T., Roberts, Edda F., Clemens, James A.

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Characterization by electrospray mass spectrometry of human Ca(2+)-sensitive cytosolic phospholipase A2 produced in baculovirus-infected insect cells by Becker, G W, Miller, J R, Kovacevic, S, Ellis, R M, Louis, A I, Small, J S, Stark, D H, Roberts, E F, Wyrick, T K, Hoskins, J

“…The 85-kD cytosolic phospholipase A2 (cPLA2) is a novel receptor-regulated phospholipase that is thought to initiate the production of inflammatory lipid…”
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Characterization by Electrospray Mass Spectrometry of Human Ca 2+ -sensitive Cytosolic Phospholipase A 2 Produced in Baculovirus-infected Insect Cells by Becker, Gerald W, Miller, James R, Kovacevic, Steven, Ellis, Robert M, Louis, Andrew I, Small, Jennifer S, Stark, Daniel H, Roberts, Edda F, Wyrick, Tamara K, Hoskins, JoAnn, Chiou, X. Grace, Sharp, John D, McClure, Don B, Riggin, Ralph M, Kramer, Ruth M

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