Search Results - "Roberts, Dean W"

Mechanisms of acetaminophen-induced liver necrosis by Hinson, Jack A, Roberts, Dean W, James, Laura P

“…Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal. Acetaminophen…”
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Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure by JAMES, Laura P, LETZIG, Lynda, SIMPSON, Pippa M, CAPPARELLI, Edmund, ROBERTS, Dean W, HINSON, Jack A, DAVERN, Timothy J, LEE, William M

“…Acetaminophen (APAP)-induced liver toxicity occurs with formation of APAP-protein adducts. These adducts are formed by hepatic metabolism of APAP to N -acetyl-…”
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Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures by Hartman, Jessica H., Letzig, Lynda G., Roberts, Dean W., James, Laura P., Fifer, E.Kim, Miller, Grover P.

“…[Display omitted] Risk assessment for exposure to mixtures of drugs and pollutants relies heavily on in vitro characterization of their bioactivation and/or…”
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Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro by Tolleson, William H, Doerge, Daniel R, Churchwell, Mona I, Marques, M. Matilde, Roberts, Dean W

“…Biochanin A and formononetin are abundant in legumes. These proestrogenic isoflavones can be converted by 4‘-O-demethylation to the more potent phytoestrogens…”
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Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover) by Roberts, Dean W, Doerge, Daniel R, Churchwell, Mona I, Gamboa da Costa, Gonçalo, Marques, M. Matilde, Tolleson, William H

“…Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783−4790), it was demonstrated…”
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Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase by Agarwal, Rakhee, MacMillan-Crow, Lee Ann, Rafferty, Tonya M, Saba, Hamida, Roberts, Dean W, Fifer, E Kim, James, Laura P, Hinson, Jack A

“…In overdose the analgesic/antipyretic acetaminophen (APAP) is hepatotoxic. Toxicity is mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine…”
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An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure by Roberts, Dean W, Lee, William M, Hinson, Jack A, Bai, Shasha, Swearingen, Christopher J, Stravitz, R. Todd, Reuben, Adrian, Letzig, Lynda, Simpson, Pippa M, Rule, Jody, Fontana, Robert J, Ganger, Daniel, Reddy, K. Rajender, Liou, Iris, Fix, Oren, James, Laura P

“…Background & Aims A rapid and reliable point-of-care assay to detect acetaminophen protein adducts in the serum of patients with acute liver injury could…”
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Lactoperoxidase-Catalyzed Activation of Carcinogenic Aromatic and Heterocyclic Amines by Gorlewska-Roberts, Katarzyna M, Teitel, Candee H, Lay, Jackson O, Roberts, Dean W, Kadlubar, Fred F

“…Lactoperoxidase, an enzyme secreted from the human mammary gland, plays a host defensive role through antimicrobial activity. It has been implicated in…”
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Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin by Gopee, Neera V., Roberts, Dean W., Webb, Peggy, Cozart, Christy R., Siitonen, Paul H., Latendresse, John R., Warbitton, Alan R., Yu, William W., Colvin, Vicki L., Walker, Nigel J., Howard, Paul C.

“…Many cosmetics, sunscreens, and other consumer products are reported to contain nanoscale materials. The possible transdermal absorption of nanoscale materials…”
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Mouse liver protein sulfhydryl depletion after acetaminophen exposure by Yang, Xi, Greenhaw, James, Shi, Qiang, Roberts, Dean W, Hinson, Jack A, Muskhelishvili, Levan, Davis, Kelly, Salminen, William F

“…Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many countries. This study determined the extent of liver protein…”
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Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice by Gopee, Neera V., Roberts, Dean W., Webb, Peggy, Cozart, Christy R., Siitonen, Paul H., Warbritton, Alan R., Yu, William W., Colvin, Vicki L., Walker, Nigel J., Howard, Paul C.

“…Topical exposure to nanoscale materials is likely from a variety of sources including sunscreens and cosmetics. Because the in vivo disposition of nanoscale…”
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Advances in biomarker development in acetaminophen toxicity by James, Laura P, McGill, Mitchell R, Roberts, Dean W, Hinson, Jack A, Lee, William M

“…Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced…”
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Changes in mouse liver protein glutathionylation after acetaminophen exposure by Yang, Xi, Greenhaw, James, Ali, Akhtar, Shi, Qiang, Roberts, Dean W, Hinson, Jack A, Muskhelishvili, Levan, Beger, Richard, Pence, Lisa M, Ando, Yosuke, Sun, Jinchun, Davis, Kelly, Salminen, William F

“…The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300…”
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Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice by Beland, F.A, Benson, R.W, Mellick, P.W, Kovatch, R.M, Roberts, D.W, Fang, J.L, Doerge, D.R

“…Urethane is a carcinogen to which there is widespread exposure through the consumption of fermented foods and alcoholic beverages. In this study, we have…”
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A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression by Zhou, Xin, Wei, Yuan, Xie, Fang, Laukaitis, Christina M, Karn, Robert C, Kluetzman, Kerri, Gu, Jun, Zhang, Qing-Yu, Roberts, Dean W, Ding, Xinxin

“…To identify novel factors or mechanisms that are important for the resistance of tissues to chemical toxicity, we have determined the mechanisms underlying the…”
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The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells by LAVIGNE, Jackie A, GOODMAN, Julie E, FONONG, Tekum, ODWIN, Shelly, PING HE, ROBERTS, Dean W, YAGER, James D

“…Many of the major identified risk factors for breast cancer are associated with exposure to endogenous estrogen. In addition to the effects of estrogen as a…”
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Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome by WOLFF, GEORGE L, ROBERTS, DEAN W, MOUNTJOY, KATHLEEN G

“…1 Division of Biochemical Toxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson 72079 2 Department of…”
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Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptosis by Mercer, Kelly E, Apostolov, Eugene O, Gamboa da Costa, Goncalo, Yu, Xinfeng, Lang, Patrick, Roberts, Dean W, Davis, Warren, Basnakian, Alexei G, Kadlubar, Fred F, Kadlubar, Susan A

“…Previously, we reported a strong association of the high activity SULT1A1*1 allele and overall survival of patients receiving tamoxifen therapy, indicating…”
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55 Identifying Acetaminophen (APAP) Toxicity Amongst Indeterminate Cause of Acute Liver Failure (Alf) by Khandelwal, Niraj, James, Laura P, Simpson, Pippa M, Davern, Timothy J, Roberts, Dean W, Lee, William M

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Quantitative Analysis of Etheno-2‘-Deoxycytidine DNA Adducts Using On-Line Immunoaffinity Chromatography Coupled With LC/ES-MS/MS Detection by Roberts, Dean W, Churchwell, Mona I, Beland, Frederick A, Fang, Jia-Long, Doerge, Daniel R

“…Etheno DNA adducts, including 3,N 4-etheno-2‘-deoxycytidine (etheno-dC), are promutagenic lesions present in normal animal and human tissues. These DNA adducts…”
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