Search Results - "Roberts, David J."

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition by Roberts, David J., Tan-Sah, Valerie P., Ding, Eric Y., Smith, Jeffery M., Miyamoto, Shigeki

“…Hexokinase-II (HK-II) catalyzes the first step of glycolysis and also functions as a protective molecule; however, its role in protective autophagy has not…”
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Blood services, COVID‐19 and lessons being learnt: the past pandemic is not over, it's not even past by Roberts, David J.

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A difficult year… so keep on keeping on by Roberts, David J.

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The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review by Fisher, Sheila A, Rahimzadeh, Mana, Brierley, Charlotte, Gration, Betty, Doree, Carolyn, Kimber, Catherine E, Plaza Cajide, Alicia, Lamikanra, Abigail A, Roberts, David J

“…The evidence for vitamin D and other agents that experimentally modulate T regulatory cells (Tregs) for the treatment of patients with autoimmune or allergic…”
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Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes by Roberts, David J., Tan-Sah, Valerie P., Smith, Jeffery M., Miyamoto, Shigeki

“…Hexokinase II (HK-II) is an enzyme that catalyzes the first step in glycolysis and localizes not only in the cytosol but also at mitochondria. Akt, activated…”
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Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income by Hill, W. David, Davies, Neil M., Ritchie, Stuart J., Skene, Nathan G., Bryois, Julien, Bell, Steven, Di Angelantonio, Emanuele, Roberts, David J., Xueyi, Shen, Davies, Gail, Liewald, David C. M., Porteous, David J., Hayward, Caroline, Butterworth, Adam S., McIntosh, Andrew M., Gale, Catharine R., Deary, Ian J.

“…Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a…”
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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke by Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

“…Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal…”
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Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure by Thomas, Robert L, Roberts, David J, Kubli, Dieter A, Lee, Youngil, Quinsay, Melissa N, Owens, Jarvis B, Fischer, Kimberlee M, Sussman, Mark A, Miyamoto, Shigeki, Gustafsson, Åsa B

“…Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in several human cancers. MCL-1 is also highly expressed in myocardium,…”
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The role of health protection teams in reducing health inequities: findings from a qualitative study by Allison, Rosalie, Roberts, David J, Briggs, Adam, Arora, Shona, Anderson, Sarah

“…The UK Health Security Agency's (UKHSA) Health Protection Teams (HPTs) provide specialist public health advice and operational support to NHS, local…”
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Neuronal Diversity in GABAergic Long-Range Projections from the Hippocampus by Jinno, Shozo, Klausberger, Thomas, Marton, Laszlo F, Dalezios, Yannis, Roberts, J. David B, Fuentealba, Pablo, Bushong, Eric A, Henze, Darrell, Buzsaki, Gyorgy, Somogyi, Peter

“…The formation and recall of sensory, motor, and cognitive representations require coordinated fast communication among multiple cortical areas. Interareal…”
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Cost-effectiveness of alternative minimum recall intervals between whole blood donations by Sadique, Zia, Willis, Sarah, Corte, Kaat De, Pennington, Mark, Moore, Carmel, Kaptoge, Stephen, Angelantonio, Emanuele Di, Miflin, Gail, Roberts, David J, Grieve, Richard

“…The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to…”
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Genetically personalised organ-specific metabolic models in health and disease by Foguet, Carles, Xu, Yu, Ritchie, Scott C., Lambert, Samuel A., Persyn, Elodie, Nath, Artika P., Davenport, Emma E., Roberts, David J., Paul, Dirk S., Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S., Yau, Christopher, Inouye, Michael

“…Understanding how genetic variants influence disease risk and complex traits (variant-to-function) is one of the major challenges in human genetics. Here we…”
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Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania by Makani, Julie, Cox, Sharon E, Soka, Deogratius, Komba, Albert N, Oruo, Julie, Mwamtemi, Hadija, Magesa, Pius, Rwezaula, Stella, Meda, Elineema, Mgaya, Josephine, Lowe, Brett, Muturi, David, Roberts, David J, Williams, Thomas N, Pallangyo, Kisali, Kitundu, Jesse, Fegan, Gregory, Kirkham, Fenella J, Marsh, Kevin, Newton, Charles R

“…The World Health Organization has declared Sickle Cell Anemia (SCA) a public health priority. There are 300,000 births/year, over 75% in Africa, with estimates…”
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Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients by Telfer, Paul, De la Fuente, Josu, Sohal, Mamta, Brown, Ralph, Eleftheriou, Perla, Roy, Noémi, Piel, Frédéric B, Chakravorty, Subarna, Gardner, Kate, Velangi, Mark, Drasar, Emma, Shah, Farrukh, Porter, John B, Trompeter, Sara, Atoyebi, Wale, Szydlo, Richard, Anie, Kofi A, Ryan, Kate, Sharif, Joseph, Wright, Josh, Astwood, Emma, Nicolle, C Sarah, Webster, Amy, Roberts, David J, Lugthart, Sanne, Kaya, Banu, Awogbade, Moji, Rees, David C, Hollingsworth, Rob, Inusa, Baba, Howard, Jo, Layton, D Mark

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Seroprevalence of SARS-CoV-2 among Blood Donors and Changes after Introduction of Public Health and Social Measures, London, UK by Amirthalingam, Gayatri, Whitaker, Heather, Brooks, Tim, Brown, Kevin, Hoschler, Katja, Linley, Ezra, Borrow, Ray, Brown, Colin, Watkins, Nick, Roberts, David J, Solomon, Danielle, Gower, Charlotte M, Waroux, Olivier le Polain de, Andrews, Nick J, Ramsay, Mary E

“…We describe results of testing blood donors in London, UK, for severe acute respiratory disease coronavirus 2 (SARS-CoV-2) IgG before and after lockdown…”
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Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo by Klausberger, Thomas, Magill, Peter J, Márton, László F, Roberts, J. David B, Cobden, Philip M, Buzsáki, György, Somogyi, Peter

“…Neural-network oscillations at distinct frequencies have been implicated in the encoding, consolidation and retrieval of information in the hippocampus. Some…”
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Malarial anemia: of mice and men by Lamikanra, Abigail A., Brown, Douglas, Potocnik, Alexandre, Casals-Pascual, Climent, Langhorne, Jean, Roberts, David J.

“…Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial…”
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Problems and Approaches for Blood Transfusion in the Developing Countries by Roberts, David J., DPhil, MRCP, FRCPath, Field, Stephen, MMed(Path) (SA), FCPath (SA), Delaney, Meghan, DO, MPH, Bates, Imelda, FRCP, FRCPath

“…A safe supply of blood and the knowledge, skill, and resources for the appropriate use of blood are essential for medical services. Many problems are faced in…”
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Summary results of the 2014-2015 DARPA Chikungunya challenge by Del Valle, Sara Y, McMahon, Benjamin H, Asher, Jason, Hatchett, Richard, Lega, Joceline C, Brown, Heidi E, Leany, Mark E, Pantazis, Yannis, Roberts, David J, Moore, Sean, Peterson, A Townsend, Escobar, Luis E, Qiao, Huijie, Hengartner, Nicholas W, Mukundan, Harshini

“…Emerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of…”
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Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation by Frise, Matthew C., Holdsworth, David A., Johnson, Andrew W., Chung, Yu Jin, Curtis, M. Kate, Cox, Pete J., Clarke, Kieran, Tyler, Damian J., Roberts, David J., Ratcliffe, Peter J., Dorrington, Keith L., Robbins, Peter A.

“…Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are incompletely characterised, but animal and human experiments suggest the…”
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