Search Results - "Roberts, Christine M."

Amyloid beta acts synergistically as a pro-inflammatory cytokine by LaRocca, Thomas J., Cavalier, Alyssa N., Roberts, Christine M., Lemieux, Maddie R., Ramesh, Pooja, Garcia, Micklaus A., Link, Christopher D.

“…The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However,…”
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Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21 by Gonzales, Patrick K, Roberts, Christine M, Fonte, Virginia, Jacobsen, Connor, Stein, Gretchen H, Link, Christopher D

“…Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations…”
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Neurotoxic effects of TDP-43 overexpression in C. elegans by Ash, Peter E.A., Zhang, Yong-Jie, Roberts, Christine M., Saldi, Tassa, Hutter, Harald, Buratti, Emanuele, Petrucelli, Leonard, Link, Christopher D.

“…RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar…”
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Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease by McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A

“…The definitive indicator of Alzheimer's disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based…”
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TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA by Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido-Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D

“…Caenorhabditis elegans mutants deleted for TDP‐1, an ortholog of the neurodegeneration‐associated RNA‐binding protein TDP‐43, display only mild phenotypes…”
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In vivo induction of membrane damage by β-amyloid peptide oligomers by Julien, Carl, Tomberlin, Colson, Roberts, Christine M, Akram, Aumbreen, Stein, Gretchen H, Silverman, Michael A, Link, Christopher D

“…Exposure to the β-amyloid peptide (Aβ) is toxic to neurons and other cell types, but the mechanism(s) involved are still unresolved. Synthetic Aβ oligomers can…”
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A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo by Fonte, Virginia, Dostal, Vishantie, Roberts, Christine M, Gonzales, Patrick, Lacor, Pascale N, Lacor, Pascale, Velasco, Pauline T, Magrane, Jordi, Dingwell, Natalie, Fan, Emily Y, Silverman, Michael A, Stein, Gretchen H, Link, Christopher D

“…The β-amyloid peptide (Aβ) contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the…”
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Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity by Dostal, Vishantie, Roberts, Christine M, Link, Christopher D

“…Epidemiological studies have reported that coffee and/or caffeine consumption may reduce Alzheimer's disease (AD) risk. We found that coffee extracts can…”
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The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2 by Saldi, Tassa K., Gonzales, Patrick, Garrido-Lecca, Alfonso, Dostal, Vishantie, Roberts, Christine M., Petrucelli, Leonard, Link, Christopher D.

“…TDP-1 is the Caenorhabditis elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic…”
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The β amyloid peptide can act as a modular aggregation domain by Link, Christopher D, Fonte, Virginia, Roberts, Christine M, Hiester, Brian, Silverman, Michael A, Stein, Gretchen H

“…Abstract Although there is compelling evidence that the β amyloid peptide (Aβ) can be centrally involved in Alzheimer's disease, the natural role (if any) of…”
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Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein by Fonte, Virginia, Kipp, D. Randal, Yerg, John, Merin, David, Forrestal, Margaret, Wagner, Eileen, Roberts, Christine M., Link, Christopher D.

“…Expression of the human β-amyloid peptide (Aβ) in a transgenic Caenorhabditis elegans Alzheimer disease model leads to the induction of HSP-16 proteins, a…”
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The development of an instrument to measure teachers' use of fear appeals in the GCSE classroom by Putwain, David W., Roberts, Christine M.

“…Background Previous work has suggested that teachers of General Certificate of Secondary Education classes may use fear appeals as a motivational device but…”
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Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection by Kokona, Bashkim, May, Carrie A., Cunningham, Nicole R., Richmond, Lynn, Jay Garcia, F., Durante, Julia C., Ulrich, Kathleen M., Roberts, Christine M., Link, Christopher D., Stafford, Walter F., Laue, Thomas M., Fairman, Robert

“…This work explores the heterogeneity of aggregation of polyglutamine fusion constructs in crude extracts of transgenic Caenorhabditis elegans animals. The work…”
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Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans by Kim, Surin A, D’Acunto, Victoria F, Kokona, Bashkim, Hofmann, Jennifer, Cunningham, Nicole R, Bistline, Emily M, Garcia, F. Jay, Akhtar, Nabeel M, Hoffman, Susanna H, Doshi, Seema H, Ulrich, Kathleen M, Jones, Nicholas M, Bonini, Nancy M, Roberts, Christine M, Link, Christopher D, Laue, Thomas M, Fairman, Robert

“…At least nine neurodegenerative diseases that are caused by the aggregation induced by long tracts of glutamine sequences have been identified. One such…”
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Fear and efficacy appeals in the classroom: the secondary teachers' perspective by Putwain, David W., Roberts, Christine M.

“…Previous research has examined the use of classroom fear and efficacy appeals from a student perspective, but little is known about teachers' views towards…”
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Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease by McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A

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Coffee protects against in vivo Abeta toxicity via activation of the skn-1 (Nrf2) detoxification pathway by Link, Christopher D, Dostal, Vishantie, Roberts, Christine M

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Caspase 7 Is a Positional Candidate Gene for IDDM 17 in a Bedouin Arab Family by BABU, SUNANDA R., BAO, FEI, ROBERTS, CHRISTINE M., MARTIN, ALLISON K., GOWAN, KATHERINE, EISENBARTH, GEORGE S., FAIN, PAMELA R.

“…: The IDDM 17 locus was mapped to an 8‐cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7…”
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Stepping Up Psychosis: The Use of Virtual Reality in Pre-registration Mental Health Nursing Education by Roberts, Christine M., Hulme, Kate A., McCann, Niall

“…•Article highlights how emerging technologies can support higher education learning to provide safe environments for students to learn.•Virtual reality can…”
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Genetic prediction of autoimmunity: Initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4–DQ8 relatives of patients with type 1A diabetes by Aly, Theresa A., Ide, Akane, Humphrey, Kurt, Barker, Jennifer M., Steck, Andrea, Erlich, Henry A., Yu, Liping, Miao, Dongmei, Redondo, Maria J., McFann, Kim, Roberts, Christine M., Babu, Sunanda R., Norris, Jill M., Eisenbarth, George S., Rewers, Marian J.

“…In this study, the combined risk for expressing anti-islet autoantibodies and type 1A diabetes (T1D) was prospectively examined in 85 sampled relatives who had…”
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