Search Results - "Roberts, Billy J"

Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors by Rewcastle, Gordon W, Murray, Donna K, Elliott, William L, Fry, David W, Howard, Curtis T, Nelson, James M, Roberts, Billy J, Vincent, Patrick W, Hollis Showalter, H. D, Winters, R. Thomas, Denny, William A

“…The 4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidine PD 158780 is a very potent in vitro inhibitor of the tyrosine kinase activity of the epidermal growth…”
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Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation by Hoeschele, James D, Showalter, H. D. Hollis, Kraker, Alan J, Elliott, William L, Roberts, Billy J, Kampf, Jeff W

“…The first two analogs 5a,b of a new class of neutral large-ring square-planar Pt(II) chelate complexes of the generic structure [Pt(cis-1,4-dach)X2] were…”
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Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors by Klutchko, Sylvester R, Zhou, Hairong, Winters, R. Thomas, Tran, Tuan P, Bridges, Alexander J, Althaus, Irene W, Amato, Danielle M, Elliott, William L, Ellis, Paul A, Meade, Mary Ann, Roberts, Billy J, Fry, David W, Gonzales, Andrea J, Harvey, Patricia J, Nelson, James M, Sherwood, Veronica, Han, Hyo-Kyung, Pace, Gerry, Smaill, Jeff B, Denny, William A, Showalter, H. D. Hollis

“…Structure−activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and…”
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity by Klutchko, Sylvester R, Hamby, James M, Boschelli, Diane H, Wu, Zhipei, Kraker, Alan J, Amar, Aneesa M, Hartl, Brian G, Shen, Cynthia, Klohs, Wayne D, Steinkampf, Randall W, Driscoll, Denise L, Nelson, James M, Elliott, William L, Roberts, Billy J, Stoner, Chad L, Vincent, Patrick W, Dykes, Donald J, Panek, Robert L, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Hallak, Hussein, Bradford, Laura A, Showalter, H. D. Hollis, Doherty, Annette M

“…While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2,3-d]pyrimidin-7(8H)-ones as a…”
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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor by Smaill, Jeff B, Palmer, Brian D, Rewcastle, Gordon W, Denny, William A, McNamara, Dennis J, Dobrusin, Ellen M, Bridges, Alexander J, Zhou, Hairong, Showalter, H. D. Hollis, Winters, R. Thomas, Leopold, Wilbur R, Fry, David W, Nelson, James M, Slintak, Veronika, Elliot, William L, Roberts, Billy J, Vincent, Patrick W, Patmore, Sandra J

“…A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR)…”
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Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice by KUNKEL, M. W, HOOK, K. E, HOWARD, C. T, PRZYBANOWSKI, S, ROBERTS, B. J, ELLIOTT, W. L, LEOPOLD, W. R

“…PD153035 is a potent (Ki = 6 pm) and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase that suppresses tyrosine phosphorylation…”
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Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2)](2-methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo by ELLIOTT, W. L, ROBERTS, B. J, HOWARD, C. T, LEOPOLD, W. R

“…[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4- butane-diamine-N,N')platinum (CI-973) is a cisplatin analogue that is currently in clinical…”
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Annually and monthly resolved solar irradiance and atmospheric temperature data across the Hawaiian archipelago from 1998 to 2015 with interannual summary statistics by Bryce, Richard, Losada Carreño, Ignacio, Kumler, Andrew, Hodge, Bri-Mathias, Roberts, Billy, Brancucci Martinez-Anido, Carlo

“…This article contains data and summary statistics of solar irradiance and dry bulb temperature across the Hawaiian archipelago resolved on a monthly basis and…”
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Toxicity and anticancer activity of a new triazine antifolate (NSC 127755) by Corbett, T H, Leopold, W R, Dykes, D J, Roberts, B J, Griswold, Jr, D P, Schabel, Jr, F M

“…A new triazine folate antagonist, 3-chloro-4-((4-(2-chloro-4-[4,6-diamino-2,2-dimethyl-s-triazin-1(2H)-yl]phenyl)butyl)) benzenesulfonyl fluoride compounded…”
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Understanding Inter-Annual Variability of PV Energy Production in the Contiguous United States by Maclaurin, Galen, Cole, Wesley, Lopez, Anthony, Reimers, Andrew, Rosenlieb, Evan, Roberts, Billy

“…Year-to-year variability of photovoltaic (PV) generation is an important factor for project financing as well as for modeling the reliability and resource…”
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Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts by VINCENT, P. W, BRIDGES, A. J, ELLIOTT, W. L, DYKES, D. J, FRY, D. W, LEOPOLD, W. R, PATMORE, S. J, ROBERTS, B. J, ROSE, S, SHERWOOD, V, HAIRONG ZHOU

“…The involvement of the EGF receptor (EGFr) family of receptors in cancers suggests that a selective inhibitor of the tyrosine kinase activity of the EGFr…”
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Anticancer activity of the structurally novel antibiotic CI-920 and its analogues by LEOPOLD, W. R, SHILLIS, J. L, MERTUS, A. E, NELSON, J. M, ROBERTS, B. J, JACKSON, R. C

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Preclinical antitumor activity of CI-973,[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2 methyl-1,4-butane-diamine-N,N')platinum by KRAKER, A. J, MOORE, C. W, ROBERTS, B. J, LEOPOLD, W. R, ELLIOTT, W. L

“…The antitumor activity of [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato-(2-)](2 methyl-1,4-butanediamine-N,N')platinum (CI-973) was characterized in a number of…”
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In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721) by ROBERTS, B. J, HAMELEHLE, K. L, SEBOLT, J. S, LEOPOLD, W. R

“…CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They…”
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Cell cycle effects of trimetrexate (CI-898) by HOOK, K. E, NELSON, J. M, ROBERTS, B. J, GRISWOLD, D. P, LEOPOLD, W. R

“…The cell cycle phase specificity of trimetrexate (CI-898) was examined. CHO cells synchronized by mitotic selection were exposed to 50 microM trimetrexate for…”
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Absence of delayed lethality in mice treated with aclacinomycin A by Corbett, T H, Griswold, Jr, D P, Roberts, B J, Schabel, Jr, F M

“…Two compounds that bind to or intercalate with DNA (DNA binders), e.g., adriamycin and 'dihydroxyanthracenedione', 9,10-anthracenedione,…”
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The biochemical pharmacology of CI-920, a structurally novel antibiotic with antileukemic activity by Jackson, R C, Fry, D W, Boritzki, T J, Roberts, B J, Hook, K E, Leopold, W R

“…CI-920 is a structurally novel, phosphate-containing polyene lactone antitumor agent isolated from a previously undescribed subspecies of Streptomyces…”
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