Search Results - "Roberts, Adam"

Development and evaluation of TaqMan-based, one-step, real-time RT-PCR assays for pepper mild mottle virus detection for near source tracking and wastewater-based epidemiology validation by Cantillon, Daire, Roberts, Adam P

“…Emergence of novel human pathogens pose significant challenges to human health as highlighted by the SARS-CoV-2 pandemic. Wastewater based epidemiology (WBE)…”
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Identification of novel transcripts in annotated genomes using RNA-Seq by ROBERTS, Adam, PIMENTEL, Harold, TRAPNELL, Cole, PACHTER, Lior

“…We describe a new 'reference annotation based transcript assembly' problem for RNA-Seq data that involves assembling novel transcripts in the context of an…”
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Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis by Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.

“…Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with…”
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(Inter)nationalising the antibiotic research and development pipeline by Singer, Andrew C, Kirchhelle, Claas, Roberts, Adam P

“…In this Personal View, we critically examine the wider context of international efforts to stimulate commercial antibiotic research and development via…”
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Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder by Johansson, Markus H K, Bortolaia, Valeria, Tansirichaiya, Supathep, Aarestrup, Frank M, Roberts, Adam P, Petersen, Thomas N

“…Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat to public health globally. In these bacteria, antimicrobial resistance genes…”
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Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance by Roberts, Adam P., Mullany, Peter

“…Abstract Antibiotic-resistant Gram-positive bacteria are responsible for morbidity and mortality in healthcare environments. Enterococcus faecium, Enterococcus…”
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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential by Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russell, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.

“…Trimethylamine N-oxide (TMAO) is a gut microbiota–derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal…”
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Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania by Wyllie, Susan, Roberts, Adam J, Norval, Suzanne, Patterson, Stephen, Foth, Bernardo J, Berriman, Matthew, Read, Kevin D, Fairlamb, Alan H

“…Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds…”
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Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli by Podnecky, Nicole L., Fredheim, Elizabeth G. A., Kloos, Julia, Sørum, Vidar, Primicerio, Raul, Roberts, Adam P., Rozen, Daniel E., Samuelsen, Ørjan, Johnsen, Pål J.

“…There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one…”
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Transformative Military Occupation: Applying the Laws of War and Human Rights by Roberts, Adam

“…Within the existing framework of international law, is it legitimate for an occupying power, in the name of creating the conditions for a more democratic and…”
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Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease by Gupta, Nilaksh, Buffa, Jennifer A., Roberts, Adam B., Sangwan, Naseer, Skye, Sarah M., Li, Lin, Ho, Karen J., Varga, John, DiDonato, Joseph A., Tang, W.H. Wilson, Hazen, Stanley L.

“…OBJECTIVE:Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and…”
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Embracing the monsters: moving from infection control to microbial management by Kirchhelle, Claas, Roberts, Adam P

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Mobile genetic elements in Clostridium difficile and their role in genome function by Mullany, Peter, Allan, Elaine, Roberts, Adam P.

“…Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This…”
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Sale of UK's Vaccine Manufacturing and Innovation Centre by Glover, Rebecca E, Roberts, Adam P, Singer, Andrew C, Kirchhelle, Claas

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The Transposon Registry by Tansirichaiya, Supathep, Rahman, Md. Ajijur, Roberts, Adam P

“…Abstract Transposable elements in prokaryotes are found in many forms and therefore a robust nomenclature system is needed in order to allow researchers to…”
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Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery by Blockley, Alix, Elliott, David, Roberts, Adam, Sweet, Michael

“…Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such…”
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Development of pBACpAK entrapment vector derivatives to detect intracellular transfer of mobile genetic elements within chloramphenicol resistant bacterial isolates by Goodman, Richard N., Tansirichaiya, Supathep, Roberts, Adam P.

“…Antimicrobial resistance disseminates throughout bacterial populations via horizontal gene transfer, driven mainly by mobile genetic elements (MGEs)…”
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XPS guide: Charge neutralization and binding energy referencing for insulating samples by Baer, Donald R., Artyushkova, Kateryna, Cohen, Hagai, Easton, Christopher D., Engelhard, Mark, Gengenbach, Thomas R., Greczynski, Grzegorz, Mack, Paul, Morgan, David J., Roberts, Adam

“…This guide deals with methods to control surface charging during XPS analysis of insulating samples and approaches to extracting useful binding energy…”
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The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome by Roberts, Adam P, Kreth, Jens

“…The oral microbiome is composed of a multitude of different species of bacteria, each capable of occupying one or more of the many different niches found…”
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A modular master on the move: the Tn916 family of mobile genetic elements by Roberts, Adam P, Mullany, Peter

“…The Tn916 family is a group of mobile genetic elements that are widespread among many commensal and pathogenic bacteria. These elements are found primarily,…”
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