Search Results - "Roberti, Maria Paula"

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors by Pitt, Jonathan M., Vétizou, Marie, Daillère, Romain, Roberti, María Paula, Yamazaki, Takahiro, Routy, Bertrand, Lepage, Patricia, Boneca, Ivo Gomperts, Chamaillard, Mathias, Kroemer, Guido, Zitvogel, Laurence

“…Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological…”
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Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15 by Rocca, Yamila Sol, Roberti, María Paula, Juliá, Estefanía Paula, Pampena, María Betina, Bruno, Luisina, Rivero, Sergio, Huertas, Eduardo, Sánchez Loria, Fernando, Pairola, Alejandro, Caignard, Anne, Mordoh, José, Levy, Estrella Mariel

“…The clinical outcome of colorectal cancer (CRC) is associated with the immune response; thus, these tumors could be responsive to different immune therapy…”
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Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma by Jacquelot, Nicolas, Enot, David P, Flament, Caroline, Vimond, Nadège, Blattner, Carolin, Pitt, Jonathan M, Yamazaki, Takahiro, Roberti, María Paula, Daillère, Romain, Vétizou, Marie, Poirier-Colame, Vichnou, Semeraro, Michaëla, Caignard, Anne, Slingluff, Jr, Craig L, Sallusto, Federica, Rusakiewicz, Sylvie, Weide, Benjamin, Marabelle, Aurélien, Kohrt, Holbrook, Dalle, Stéphane, Cavalcanti, Andréa, Kroemer, Guido, Di Giacomo, Anna Maria, Maio, Michele, Wong, Phillip, Yuan, Jianda, Wolchok, Jedd, Umansky, Viktor, Eggermont, Alexander, Zitvogel, Laurence

“…Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients…”
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Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells by Barrio, María Marcela, Abes, Riad, Colombo, Marina, Pizzurro, Gabriela, Boix, Charlotte, Roberti, María Paula, Gélizé, Emmanuelle, Rodriguez-Zubieta, Mariana, Mordoh, José, Teillaud, Jean-Luc

“…Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells…”
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Metallothionein expression in colorectal cancer: relevance of different isoforms for tumor progression and patient survival by Arriaga, Juan Martín, MSc, Levy, Estrella Mariel, PhD, Bravo, Alicia Inés, MD, Bayo, Sergio Morales, MD, Amat, Mora, MD, Aris, Mariana, MSc, Hannois, Adrián, MD, Bruno, Luisina, MD, Roberti, María Paula, MSc, Loria, Fernando Sánchez, MD, Pairola, Alejandro, MD, Huertas, Eduardo, MD, Mordoh, José, MD, PhD, Bianchini, Michele, PhD

“…Summary Metallothioneins are a family of small, cysteine-rich proteins with many functions. Immunohistochemical evaluation of all metallothionein 1 + 2…”
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Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice by Roberti, María Paula, Arriaga, Juan Martín, Bianchini, Michele, Quintá, Héctor Ramiro, Bravo, Alicia Inés, Levy, Estrella Mariel, Mordoh, José, Barrio, María Marcela

“…Triple negative breast cancers (TNBC) lacking hormone receptors and HER-2 amplification are very aggressive tumors. Since relevant differences between primary…”
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High neutrophil to lymphocyte ratio and decreased CD69 + NK cells represent a phenotype of high risk in early-stage breast cancer patients by Mandó, Pablo, Rizzo, Manglio, Roberti, María Paula, Juliá, Estefanía Paula, Pampena, María Betina, Pérez de la Puente, Constanza, Loza, Carlos Martín, Ponce, Carolina, Nadal, Jorge, Coló, Federico Andres, Mordoh, José, Levy, Estrella Mariel

“…Breast cancer (BC) is a highly heterogeneous disease presenting a broad range of clinical and molecular characteristics. In the past years, a growing body of…”
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Anticancer effects of the microbiome and its products by Zitvogel, Laurence, Daillère, Romain, Roberti, María Paula, Routy, Bertrand, Kroemer, Guido

“…Key Points The evolution of cancer has been linked to shifts in the microbiome. It will be indispensable to identify individual strains and clones (rather than…”
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Resolving the Paradox of Colon Cancer Through the Integration of Genetics, Immunology, and the Microbiota by Fidelle, Marine, Yonekura, Satoru, Picard, Marion, Cogdill, Alexandria, Hollebecque, Antoine, Roberti, Maria Paula, Zitvogel, Laurence

“…While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory lymphocytes, the mechanisms accounting for the relative resistance of MSI…”
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Natural Killer Cells in Human Cancer : From Biological Functions to Clinical Applications by Levy, Estrella Mariel, Roberti, María Paula, Mordoh, José

“…Natural killer (NK) cells are central components of the innate immunity. In murine models, it has been shown that NK cells can control both local tumor growth…”
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Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues by Probst, Hans Christian, Stoitzner, Patrizia, Amon, Lukas, Backer, Ronald A, Brand, Anna, Chen, Jianzhou, Clausen, Björn E, Dieckmann, Sophie, Dudziak, Diana, Heger, Lukas, Hodapp, Katrin, Hornsteiner, Florian, Hovav, Avi-Hai, Jacobi, Lukas, Ji, Xingqi, Kamenjarin, Nadine, Lahl, Katharina, Lahmar, Imran, Lakus, Jelena, Lehmann, Christian H K, Ortner, Daniela, Picard, Marion, Roberti, Maria Paula, Rossnagel, Lukas, Saba, Yasmin, Schalla, Carmen, Schlitzer, Andreas, Schraml, Barbara U, Schütze, Kristian, Seichter, Anna, Seré, Kristin, Seretis, Athanasios, Sopper, Sieghart, Strandt, Helen, Sykora, Martina M, Theobald, Hannah, Tripp, Christoph H, Zitvogel, Laurence

“…This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype…”
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Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis by Jacquelot, Nicolas, Roberti, María Paula, Enot, David P., Rusakiewicz, Sylvie, Semeraro, Michaela, Jégou, Sarah, Flores, Camila, Chen, Lieping, Kwon, Byoung S., Borg, Christophe, Weide, Benjamin, Aubin, François, Dalle, Stéphane, Kohrt, Holbrook, Ayyoub, Maha, Kroemer, Guido, Marabelle, Aurélien, Cavalcanti, Andréa, Eggermont, Alexander, Zitvogel, Laurence

“…Stage III metastatic melanomas require adequate adjuvant immunotherapy to prevent relapses. Prognostic factors are awaited to optimize the clinical management…”
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Turning tolerogenic into immunogenic ileal cell death through ileal microbiota: the key to unlock the mystery of colon cancer immunoscore? by Roberti, Maria Paula, Picard, Marion, Yonekura, Satoru, Zitvogel, Laurence

“…Why PD-1 blockade is ineffective in the vast majority of colorectal cancers (CCs) lacking microsatellite instability but harboring high densities of tumor…”
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MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection by Meyer, Marten, Parpoulas, Christina, Barthélémy, Titouan, Becker, Jonas P, Charoentong, Pornpimol, Lyu, Yanhong, Börsig, Selina, Bulbuc, Nadja, Tessmer, Claudia, Weinacht, Lisa, Ibberson, David, Schmidt, Patrick, Pipkorn, Rüdiger, Eichmüller, Stefan B, Steinberger, Peter, Lindner, Katharina, Poschke, Isabel, Platten, Michael, Fröhling, Stefan, Riemer, Angelika B, Hassel, Jessica C, Roberti, Maria Paula, Jäger, Dirk, Zörnig, Inka, Momburg, Frank

“…Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and…”
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Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma by Jacquelot, Nicolas, Pitt, Jonathan M., Enot, David P., Roberti, Maria Paula, Duong, Connie P. M., Rusakiewicz, Sylvie, Eggermont, Alexander M., Zitvogel, Laurence

“…Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the prognosis of cutaneous melanoma. Biomarkers for determining which…”
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Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors by Daillère, Romain, Routy, Bertrand, Goubet, Anne-Gaëlle, Cogdill, Alexandria, Ferrere, Gladys, Alves-Costa Silva, Carolina, Fluckiger, Aurélie, Ly, Pierre, Haddad, Yacine, Pizzato, Eugenie, Thelemaque, Cassandra, Fidelle, Marine, Mazzenga, Marine, Roberti, Maria Paula, Melenotte, Cléa, Liu, Peng, Terrisse, Safae, Kepp, Oliver, Kroemer, Guido, Zitvogel, Laurence, Derosa, Lisa

“…Accumulating evidence from preclinical studies and human trials demonstrated the crucial role of the gut microbiota in determining the effectiveness of…”
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Impact of the ileal microbiota on colon cancer by Roberti, Maria Paula, Rauber, Conrad, Kroemer, Guido, Zitvogel, Laurence

“…Besides tumor cell–intrinsic oncogenic pathways, host and environmental factors have a major impact on cancer immunosurveillance and the efficacy of…”
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Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects by Daillère, Romain, Vétizou, Marie, Waldschmitt, Nadine, Yamazaki, Takahiro, Isnard, Christophe, Poirier-Colame, Vichnou, Duong, Connie P.M., Flament, Caroline, Lepage, Patricia, Roberti, Maria Paula, Routy, Bertrand, Jacquelot, Nicolas, Apetoh, Lionel, Becharef, Sonia, Rusakiewicz, Sylvie, Langella, Philippe, Sokol, Harry, Kroemer, Guido, Enot, David, Roux, Antoine, Eggermont, Alexander, Tartour, Eric, Johannes, Ludger, Woerther, Paul-Louis, Chachaty, Elisabeth, Soria, Jean-Charles, Golden, Encouse, Formenti, Silvia, Plebanski, Magdalena, Madondo, Mutsa, Rosenstiel, Philip, Raoult, Didier, Cattoir, Vincent, Boneca, Ivo Gomperts, Chamaillard, Mathias, Zitvogel, Laurence

“…The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are…”
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer by Roberti, Maria Paula, Yonekura, Satoru, Duong, Connie P. M., Picard, Marion, Ferrere, Gladys, Tidjani Alou, Maryam, Rauber, Conrad, Iebba, Valerio, Lehmann, Christian H. K., Amon, Lukas, Dudziak, Diana, Derosa, Lisa, Routy, Bertrand, Flament, Caroline, Richard, Corentin, Daillère, Romain, Fluckiger, Aurélie, Van Seuningen, Isabelle, Chamaillard, Mathias, Vincent, Audrey, Kourula, Stephanie, Opolon, Paule, Ly, Pierre, Pizzato, Eugénie, Becharef, Sonia, Paillet, Juliette, Klein, Christophe, Marliot, Florence, Pietrantonio, Filippo, Benoist, Stéphane, Scoazec, Jean-Yves, Dartigues, Peggy, Hollebecque, Antoine, Malka, David, Pagès, Franck, Galon, Jérôme, Gomperts Boneca, Ivo, Lepage, Patricia, Ryffel, Bernard, Raoult, Didier, Eggermont, Alexander, Vanden Berghe, Tom, Ghiringhelli, François, Vandenabeele, Peter, Kroemer, Guido, Zitvogel, Laurence

“…The prognosis of colon cancer (CC) is dictated by tumor-infiltrating lymphocytes, including follicular helper T (T FH ) cells and the efficacy of…”
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A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers by Fidelle, Marine, Rauber, Conrad, Alves Costa Silva, Carolina, Tian, Ai-Ling, Lahmar, Imran, de La Varende, Anne-Laure Mallard, Zhao, Liwei, Thelemaque, Cassandra, Lebhar, Isabelle, Messaoudene, Meriem, Pizzato, Eugenie, Birebent, Roxanne, Mbogning Fonkou, Maxime Descartes, Zoppi, Silvia, Reni, Anna, Dalban, Cécile, Leduc, Marion, Ferrere, Gladys, Durand, Sylvère, Ly, Pierre, Silvin, Aymeric, Mulder, Kevin, Dutertre, Charles-Antoine, Ginhoux, Florent, Yonekura, Satoru, Roberti, Maria Paula, Tidjani-Alou, Maryam, Terrisse, Safae, Chen, Jianzhou, Kepp, Oliver, Schippers, Angela, Wagner, Norbert, Suárez-Gosálvez, Javier, Kobold, Sebastian, Fahrner, Jean-Eudes, Richard, Corentin, Bosq, Jacques, Lordello, Leonardo, Vitali, Giacomo, Galleron, Nathalie, Quinquis, Benoît, Le Chatelier, Emmanuelle, Blanchard, Lucas, Girard, Jean-Philippe, Jarry, Anne, Gervois, Nadine, Godefroy, Emmanuelle, Labarrière, Nathalie, Koschny, Ronald, Daillère, Romain, Besse, Benjamin, Truntzer, Caroline, Ghiringhelli, François, Coatnoan, Nicolas, Mhanna, Vanessa, Klatzmann, David, Drubay, Damien, Albiges, Laurence, Thomas, Andrew Maltez, Segata, Nicola, Danlos, François-Xavier, Marabelle, Aurélien, Routy, Bertrand, Derosa, Lisa, Kroemer, Guido, Zitvogel, Laurence

“…Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their…”
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