Search Results - "Robert V. Farese"

The biophysics and cell biology of lipid droplets by Thiam, Abdou Rachid, Farese Jr, Robert V., Walther, Tobias C.

“…Key Points Cellular lipid droplets store lipids as reservoirs for metabolic energy and membrane precursors. Lipid droplets form the dispersed phase of a…”
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Lipid Droplet Biogenesis by Walther, Tobias C, Chung, Jeeyun, Farese, Robert V

“…Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells…”
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Lipid droplets and liver disease: from basic biology to clinical implications by Gluchowski, Nina L., Becuwe, Michel, Walther, Tobias C., Farese, Robert V.

“…Key Points Depending on the body's needs, the liver utilizes lipids to generate metabolic energy, secretes them as lipoproteins, or packages them for storage…”
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Cellular Fatty Acid Metabolism and Cancer by Currie, Erin, Schulze, Almut, Zechner, Rudolf, Walther, Tobias C., Farese, Robert V.

“…Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of…”
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The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes by Chitraju, Chandramohan, Walther, Tobias C., Farese, Robert V.

“…Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is catalyzed by the evolutionarily unrelated acyl-CoA:diacylglycerol…”
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Lipid Droplets and Cellular Lipid Metabolism by Walther, Tobias C, Farese, Robert V

“…Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral…”
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Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets by Kory, Nora, Farese, Robert V, Walther, Tobias C

“…How proteins specifically localize to the phospholipid monolayer surface of lipid droplets (LDs) is being unraveled. We review here the major known pathways of…”
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Lipid droplet biogenesis by Wilfling, Florian, Haas, Joel T, Walther, Tobias C, Jr, Robert V Farese

“…Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a…”
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Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme by Sui, Xuewu, Wang, Kun, Gluchowski, Nina L., Elliott, Shane D., Liao, Maofu, Walther, Tobias C., Farese, Robert V.

“…Triacylglycerols store metabolic energy in organisms and have industrial uses as foods and fuels. Excessive accumulation of triacylglycerols in humans causes…”
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Balancing the fat: lipid droplets and human disease by Krahmer, Natalie, Farese, Robert V., Walther, Tobias C.

“…Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat…”
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LDAF1 and Seipin Form a Lipid Droplet Assembly Complex by Chung, Jeeyun, Wu, Xudong, Lambert, Talley J., Lai, Zon Weng, Walther, Tobias C., Farese, Robert V.

“…Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) to store triacylglycerol (TG) and cholesterol esters. The ER protein seipin was shown to…”
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Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis by Chitraju, Chandramohan, Fischer, Alexander W., Farese, Robert V., Walther, Tobias C.

“…Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty acids released from brown adipocyte LDs by lipolysis are thought…”
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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation by Hirschey, Matthew D, Shimazu, Tadahiro, Goetzman, Eric, Jing, Enxuan, Schwer, Bjoern, Lombard, David B, Grueter, Carrie A, Harris, Charles, Biddinger, Sudha, Ilkayeva, Olga R, Stevens, Robert D, Li, Yu, Saha, Asish K, Ruderman, Neil B, Bain, James R, Newgard, Christopher B

“…Sirtuins are NAD+-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress…”
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Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets by Prévost, Coline, Sharp, Morris E., Kory, Nora, Lin, Qingqing, Voth, Gregory A., Farese, Robert V., Walther, Tobias C.

“…Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most cells. They are unusual organelles that are bounded by a…”
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Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis by Chitraju, Chandramohan, Mejhert, Niklas, Haas, Joel T., Diaz-Ramirez, L. Grisell, Grueter, Carrie A., Imbriglio, Jason E., Pinto, Shirly, Koliwad, Suneil K., Walther, Tobias C., Farese, Robert V.

“…Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed…”
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Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets by Wilfling, Florian, Wang, Huajin, Haas, Joel T., Krahmer, Natalie, Gould, Travis J., Uchida, Aki, Cheng, Ji-Xin, Graham, Morven, Christiano, Romain, Fröhlich, Florian, Liu, Xinran, Buhman, Kimberly K., Coleman, Rosalind A., Bewersdorf, Joerg, Farese, Robert V., Walther, Tobias C.

“…Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. With excess metabolic energy, cells synthesize triacylglycerol (TG) and form LDs…”
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Cryo-electron microscopy structure of the lipid droplet-formation protein seipin by Sui, Xuewu, Arlt, Henning, Brock, Kelly P, Lai, Zon Weng, DiMaio, Frank, Marks, Debora S, Liao, Maofu, Farese, Jr, Robert V, Walther, Tobias C

“…Metabolic energy is stored in cells primarily as triacylglycerols in lipid droplets (LDs), and LD dysregulation leads to metabolic diseases. The formation of…”
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Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum by Farese, Jr, Robert V, Walther, Tobias C

“…More than 60 years ago, Eugene Kennedy and coworkers elucidated the endoplasmic reticulum (ER)-based pathways of glycerolipid synthesis, including the…”
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Lipid Droplets Finally Get a Little R-E-S-P-E-C-T by Farese, Robert V., Walther, Tobias C.

“…Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting…”
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Lipid droplets at a glance by Guo, Yi, Cordes, Kimberly R, Farese, Robert V. Jr, Walther, Tobias C

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