Search Results - "Robert C. Bast, Jr"

The biology of ovarian cancer: new opportunities for translation by Bast, Robert C, Hennessy, Bryan, Mills, Gordon B

“…Key Points Several factors make ovarian cancer a difficult disease to treat effectively. Although many patients experience symptoms, these often overlap with…”
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Rethinking ovarian cancer: recommendations for improving outcomes by Bowtell, David D, Vaughan, Sebastian, Coward, Jermaine I, Bast, Robert C, Berchuck, Andy, Berek, Jonathan S, Brenton, James D, Coukos, George, Crum, Christopher C, Drapkin, Ronny, Etemadmoghadam, Dariush, Friedlander, Michael, Gabra, Hani, Kaye, Stan B, Lord, Chris J, Lengyel, Ernst, Levine, Douglas A, McNeish, Iain A, Menon, Usha, Mills, Gordon B, Nephew, Kenneth P, Oza, Amit M, Sood, Anil K, Stronach, Euan A, Walczak, Henning, Balkwill, Frances R

“…This Opinion article outlines nine major recommendations for improving our understanding of ovarian cancer and the outcomes of women with this group of…”
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SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers by Lu, Zhen, Mao, Weiqun, Yang, Hailing, Santiago-O'Farrill, Janice M, Rask, Philip J, Mondal, Jayanta, Chen, Hu, Ivan, Cristina, Liu, Xiuping, Liu, Chang-Gong, Xi, Yuanxin, Masuda, Kenta, Carrami, Eli M, Chen, Meng, Tang, Yitao, Pang, Lan, Lakomy, David S, Calin, George A, Liang, Han, Ahmed, Ahmed A, Vankayalapati, Hariprasad, Bast, Jr, Robert C

“…Poly(ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in the treatment of ovarian and breast cancers. PARP inhibitors are…”
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Bayesian Approach to Dose-Response Assessment and Synergy and Its Application to In Vitro Dose-Response Studies by Hennessey, Violeta G, Rosner, Gary L, Bast, Robert C. Jr, Chen, Min-Yu

“…Summary In this article, we propose a Bayesian approach to dose-response assessment and the assessment of synergy between two combined agents. We consider the…”
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Src family kinases and paclitaxel sensitivity by Le, Xiao-Feng, Bast, Jr, Robert C.

“…Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis…”
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DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells by Lu, Zhen, Baquero, Maria T, Yang, Hailing, Yang, Maojie, Reger, Albert S, Kim, Choel, Levine, Douglas A, Clarke, Charlotte H, Liao, Warren S-L, Bast Jr, Robert C

“…DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits…”
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Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function by Liang, Xiaowen, Jung, Sung Yun, Fong, Lon Wolf, Bildik, Gamze, Gray, Joshua P., Mao, Weiqun, Zhang, Shuxing, Millward, Steven W., Gorfe, Alemayehu A., Zhou, Yong, Lu, Zhen, Bast, Robert C.

“…DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and…”
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Reproducibility of SELDI Spectra Across Time and Laboratories by Diao, Lixia, Clarke, Charlotte H., Coombes, Kevin R., Hamilton, Stanley R., Roth, Jack, Mao, Li, Czerniak, Bogdan, Baggerly, Keith A., Morris, Jeffrey S., Fung, Eric T., Bast, Robert C.

“…The reproducibility of mass spectrometry (MS) data collected using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) has been questioned…”
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Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2 by Le, Xiao-Feng, Mao, Weiqun, Lu, Chunhua, Thornton, Angela, Heymach, John V., Sood, Anil K., Bast, Jr, Robert C.

“…We have previously reported that breast cancer cells which overexpress HER2 produce higher levels of VEGF than cells with low levels of HER2. This study tested…”
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Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor-initiating cells by Artibani, Mara, Masuda, Kenta, Hu, Zhiyuan, Rauher, Pascal C, Mallett, Garry, Wietek, Nina, Morotti, Matteo, Chong, Kay, KaramiNejadRanjbar, Mohammad, Zois, Christos E, Dhar, Sunanda, El-Sahhar, Salma, Campo, Leticia, Blagden, Sarah P, Damato, Stephen, Pathiraja, Pubudu N, Nicum, Shibani, Gleeson, Fergus, Laios, Alexandros, Alsaadi, Abdulkhaliq, Santana Gonzalez, Laura, Motohara, Takeshi, Albukhari, Ashwag, Lu, Zhen, Bast, Jr, Robert C, Harris, Adrian L, Ejsing, Christer S, Klemm, Robin W, Yau, Christopher, Sauka-Spengler, Tatjana, Ahmed, Ahmed Ashour

“…Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular…”
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American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer by HARRIS, Lyndsay, FRITSCHE, Herbert, MENNEL, Robert, NORTON, Larry, RAVDIN, Peter, TAUBE, Sheila, SOMERFIELD, Mark R, HAYES, Daniel F, BAST, Robert C

“…To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of breast cancer. For the 2007…”
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Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer: Updated Guidelines From the European Group on Tumor Markers by Sölétormos, György, Duffy, Michael J, Othman Abu Hassan, Suher, Verheijen, René H M, Tholander, Bengt, Bast, Jr, Robert C, Gaarenstroom, Katja N, Sturgeon, Catharine M, Bonfrer, Johannes M, Petersen, Per Hyltoft, Troonen, Hugo, CarloTorre, Gian, Kanty Kulpa, Jan, Tuxen, Malgorzata K, Molina, Raphael

“…To present an update of the European Group on Tumor Markers guidelines for serum markers in epithelial ovarian cancer. Systematic literature survey from 2008…”
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The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells by Lu, Zhen, Luo, Robert Z, Lu, Yiling, Zhang, Xuhui, Yu, Qinghua, Khare, Shilpi, Kondo, Seiji, Kondo, Yasuko, Yu, Yinhua, Mills, Gordon B, Liao, Warren S-L, Bast, Jr, Robert C

“…The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce autophagy and regulate its outcome in human cancers are poorly understood…”
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A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer by Wang, Fang, Yu, Xuejiao, Qian, Jun, Cao, Yumin, Dong, Shunli, Zhan, Shenghua, Lu, Zhen, Bast, Robert C., Song, Qingxia, Chen, Youguo, Zhang, Yi, Zhou, Jinhua

“…Ovarian cancer patients with HR proficiency (HRP) have had limited benefits from PARP inhibitor treatment, highlighting the need for improved therapeutic…”
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ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer by LOCKER, Gershon Y, HAMILTON, Stanley, HARRIS, Jules, JESSUP, John M, KEMENY, Nancy, MACDONALD, John S, SOMERFIELD, Mark R, HAYES, Daniel F, BAST, Robert C

“…To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of gastrointestinal cancers. For the…”
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Crizotinib Enhances PARP Inhibitor Efficacy in Ovarian Cancer Cells and Xenograft Models by Inducing Autophagy by Santiago-O'Farrill, Janice M, Blessing Bollu, Alicia, Yang, Hailing, Orellana, Vivian, Pina, Marc, Zhang, Xudong, Liu, Jinsong, Bast, Jr, Robert C, Lu, Zhen

“…Poly (ADP-ribose) polymerase inhibitors (PARPi) can encounter resistance through various mechanisms, limiting their effectiveness. Our recent research showed…”
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Development of a Multimarker Assay for Early Detection of Ovarian Cancer by YURKOVETSKY, Zoya, SKATES, Steven, MENON, Usha, LU, Karen, BADGWELL, Donna, BAST, Robert C, LOKSHIN, Anna E, LOMAKIN, Aleksey, NOLEN, Brian, PULSIPHER, Trenton, MODUGNO, Francesmary, MARKS, Jeffrey, GODWIN, Andrew, GORELIK, Elieser, JACOBS, Ian

“…Early detection of ovarian cancer has great promise to improve clinical outcome. Ninety-six serum biomarkers were analyzed in sera from healthy women and from…”
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Normal Risk Ovarian Screening Study: 21-Year Update by Han, Chae Young, Lu, Karen H, Corrigan, Gwen, Perez, Alexandra, Kohring, Sharlene D, Celestino, Joseph, Bedi, Deepak, Bedia, Enrique, Bevers, Therese, Boruta, David, Carlson, Matthew, Holman, Laura, Leeds, Leroy, Mathews, Cara, McCann, Georgia, Moore, Richard G, Schlumbrecht, Matthew, Slomovitz, Brian, Tobias, Dan, Williams-Brown, Yvette, Bevers, Michael W, Liu, Jinsong, Gornet, Terrie G, Handy, Beverly C, Lu, Zhen, Bedia, Jacob S, Skates, Steven J, Bast, Jr, Robert C

“…The Normal Risk Ovarian Screening Study (NROSS) tested a two-stage screening strategy in postmenopausal women at conventional hereditary risk where…”
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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters by Sutton, Margie N., Lu, Zhen, Li, Yao-Cheng, Zhou, Yong, Huang, Tao, Reger, Albert S., Hurwitz, Amy M., Palzkill, Timothy, Logsdon, Craig, Liang, Xiaowen, Gray, Joe W., Nan, Xiaolin, Hancock, John, Wahl, Geoffrey M., Bast, Robert C.

“…Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly with…”
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National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers by Sturgeon, Catharine M, Duffy, Michael J, Stenman, Ulf-Hakan, Lilja, Hans, Brunner, Nils, Chan, Daniel W, Babaian, Richard, Bast, Robert C., Jr, Dowell, Barry, Esteva, Francisco J, Haglund, Caj, Harbeck, Nadia, Hayes, Daniel F, Holten-Andersen, Mads, Klee, George G, Lamerz, Rolf, Looijenga, Leendert H, Molina, Rafael, Nielsen, Hans Jorgen, Rittenhouse, Harry, Semjonow, Axel, Shih, Ie-Ming, Sibley, Paul, Soletormos, Gyorgy, Stephan, Carsten, Sokoll, Lori, Hoffman, Barry R, Diamandis, Eleftherios P

“…Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been…”
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