Search Results - "Robert C Bernhards"

Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays by Welkos, Susan L, Klimko, Christopher P, Kern, Steven J, Bearss, Jeremy J, Bozue, Joel A, Bernhards, Robert C, Trevino, Sylvia R, Waag, David M, Amemiya, Kei, Worsham, Patricia L, Cote, Christopher K

“…Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative intracellular bacterium. This bacterium is endemic in Southeast…”
Get full text

Activation of Toll-Like Receptors by Live Gram-Negative Bacterial Pathogens Reveals Mitigation of TLR4 Responses and Activation of TLR5 by Flagella by Amemiya, Kei, Dankmeyer, Jennifer L, Bernhards, Robert C, Fetterer, David P, Waag, David M, Worsham, Patricia L, DeShazer, David

“…Successful bacterial pathogens have evolved to avoid activating an innate immune system in the host that responds to the pathogen through distinct Toll-like…”
Get full text

Avirulent Bacillus anthracis Strain with Molecular Assay Targets as Surrogate for Irradiation-Inactivated Virulent Spores by Plaut, Roger D, Staab, Andrea B, Munson, Mark A, Gebhardt, Joan S, Klimko, Christopher P, Quirk, Avery V, Cote, Christopher K, Buhr, Tony L, Rossmaier, Rebecca D, Bernhards, Robert C, Love, Courtney E, Berk, Kimberly L, Abshire, Teresa G, Rozak, David A, Beck, Linda C, Stibitz, Scott, Goodwin, Bruce G, Smith, Michael A, Sozhamannan, Shanmuga

“…The revelation in May 2015 of the shipment of γ irradiation-inactivated wild-type Bacillus anthracis spore preparations containing a small number of live…”
Get full text

Laser Scanning Confocal Microscopy Was Used to Validate the Presence of Burkholderia Pseudomallei or B. Mallei in Formalin-Fixed Paraffin Embedded Tissues by Amemiya, Kei, Zeng, Xiankun, Bearss, Jeremy J, Cote, Christopher K, Soffler, Carl, Bernhards, Robert C, Dankmeyer, Jennifer L, Ribot, Wilson J, Trevino, Sylvia R, Welkos, Susan L, Worsham, Patricia L, Waag, David M

“…and are Gram-negative, facultative intracellular bacteria that cause melioidosis and glanders, respectively. Currently, there are no vaccines for these two…”
Get full text

Detection of Protein Toxin Simulants from Contaminated Surfaces by Paper Spray Mass Spectrometry by Wichert, William R. A., Dhummakupt, Elizabeth S., Zhang, Chengsen, Mach, Phillip M., Bernhards, Robert C., Glaros, Trevor, Manicke, Nicholas E.

“…Proteinaceous toxins are harmful proteins derived from plants, bacteria, and other natural sources. They pose a risk to human health due to infection and also…”
Get full text

Backbone Interactions Between Transcriptional Activator ExsA and Anti-Activator ExsD Facilitate Regulation of the Type III Secretion System in Pseudomonas aeruginosa by Shrestha, Manisha, Bernhards, Robert C., Fu, Yichen, Ryan, Kylie, Schubot, Florian D.

“…The type III secretion system (T3SS) is a pivotal virulence mechanism of many Gram-negative bacteria. During infection, the syringe-like T3SS injects cytotoxic…”
Get full text

Characterization of cellular immune response and innate immune signaling in human and nonhuman primate primary mononuclear cells exposed to Burkholderia mallei by Alam, Shahabuddin, Amemiya, Kei, Bernhards, Robert C., Ulrich, Robert G., Waag, David M., Saikh, Kamal U.

“…Burkholderia pseudomallei infection causes melioidosis and is often characterized by severe sepsis. Although rare in humans, Burkholderia mallei has caused…”
Get full text

Self‐trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro by Bernhards, Robert C., Marsden, Anne E., Esher, Shannon K., Yahr, Timothy L., Schubot, Florian D.

“…The opportunistic pathogen Pseudomonas aeruginosa ranks among the leading causes of nosocomial infection. The type III secretion system (T3SS) aids acute…”
Get full text

Draft Whole-Genome Sequences of Ciprofloxacin-Resistant Derivatives of a Bacillus anthracis ΔANR Strain Lacking pXO1 and pXO2 Plasmids by Biggs, Tracey D, Karavis, Mark A, Harris, Jacquelyn V, Hill, Jessica M, Bernhards, Robert C, Price, Lance B, Keim, Paul, Goodwin, Bruce G, Sozhamannan, Shanmuga

“…Mutants of an attenuated (ΔANR) strain conferring increasing levels of ciprofloxacin resistance have been described. Here, we report the draft genome sequences…”
Get full text

Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein by Bernhards, Robert C., Jing, Xing, Vogelaar, Nancy J., Robinson, Howard, Schubot, Florian D.

“…The opportunistic pathogen P. aeruginosa utilizes a type III secretion system (T3SS) to support acute infections in predisposed individuals. In this bacterium,…”
Get full text

Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsAin vitro by Bernhards, Robert C, Marsden, Anne E, Esher, Shannon K, Yahr, Timothy L, Schubot, Florian D

“…The opportunistic pathogen Pseudomonas aeruginosa ranks among the leading causes of nosocomial infection. The type III secretion system (T3SS) aids acute…”
Get full text

Self‐trimerization of E xs D limits inhibition of the P seudomonas aeruginosa transcriptional activator E xs A in vitro by Bernhards, Robert C., Marsden, Anne E., Esher, Shannon K., Yahr, Timothy L., Schubot, Florian D.

“…The opportunistic pathogen Pseudomonas aeruginosa ranks among the leading causes of nosocomial infection. The type  III secretion system (T3 SS ) aids acute…”
Get full text

Laser scanning confocal microscopy was used to validate the presence of 'Burkholderia pseudomallei' or 'B. mallei' in formalin-fixed paraffin embedded tissues by Kei Amemiya, Xiankun Zeng, Jeremy J Bearss, Christopher K Cote, Carl Soffler, Robert C Bernhards, Jennifer L Dankmeyer, Wilson J Ribot, Sylvia R Trevino, Susan L Welkos, Patricia L Worsham, David M Waag

“…Burkholderia pseudomallei and B. mallei are Gram-negative, facultative intracellular bacteria that cause melioidosis and glanders, respectively. Currently,…”
Get full text

Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays: e0124667 by Welkos, Susan L, Klimko, Christopher P, Kern, Steven J, Bearss, Jeremy J, Bozue, Joel A, Bernhards, Robert C, Trevino, Sylvia R, Waag, David M, Amemiya, Kei, Worsham, Patricia L

“…Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative intracellular bacterium. This bacterium is endemic in Southeast…”
Get full text