Search Results - "Robert‐Paganin, Julien"

Voltage‐gating of aquaporins, a putative conserved safety mechanism during ionic stresses by Mom, Robin, Muries, Beatriz, Benoit, Pierrick, Robert‐Paganin, Julien, Réty, Stéphane, Venisse, Jean‐Stéphane, Padua, Agilio, Label, Philippe, Auguin, Daniel

“…Diversity in the response of aquaporins toward high membrane potentials. Free‐energy profile‐based correction of pf. AQP water permeability tuning through ar/R…”
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Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition by Robert-Paganin, Julien, Auguin, Daniel, Houdusse, Anne

“…Hypertrophic cardiomyopathies (HCM) result from distinct single-point mutations in sarcomeric proteins that lead to muscle hypercontractility. While different…”
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Force Generation by Myosin Motors: A Structural Perspective by Robert-Paganin, Julien, Pylypenko, Olena, Kikuti, Carlos, Sweeney, H. Lee, Houdusse, Anne

“…Generating force and movement is essential for the functions of cells and organisms. A variety of molecular motors that can move on tracks within cells have…”
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Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil by Planelles-Herrero, Vicente J., Hartman, James J., Robert-Paganin, Julien, Malik, Fady I., Houdusse, Anne

“…Omecamtiv mecarbil is a selective, small-molecule activator of cardiac myosin that is being developed as a potential treatment for heart failure with reduced…”
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Cryo-EM structure of the folded-back state of human β-cardiac myosin by Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien

“…To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’…”
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Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction by Auguin, Daniel, Robert-Paganin, Julien, Réty, Stéphane, Kikuti, Carlos, David, Amandine, Theumer, Gabriele, Schmidt, Arndt W., Knölker, Hans-Joachim, Houdusse, Anne

“…Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against…”
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Regulation of DEAH/RHA Helicases by G-Patch Proteins by Robert-Paganin, Julien, Leulliot, N., Réty, Stéphane

“…RNA helicases from the DEAH/RHA family are present in all the processes of RNA metabolism. The function of two helicases from this family, Prp2 and Prp43, is…”
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Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism by Robert-Paganin, Julien, Robblee, James P., Auguin, Daniel, Blake, Thomas C. A., Bookwalter, Carol S., Krementsova, Elena B., Moussaoui, Dihia, Previs, Michael J., Jousset, Guillaume, Baum, Jake, Trybus, Kathleen M., Houdusse, Anne

“…Plasmodium parasites are obligate intracellular protozoa and causative agents of malaria, responsible for half a million deaths each year. The lifecycle…”
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The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity by Robert-Paganin, Julien, Xu, Xiao-Ping, Swift, Mark F., Auguin, Daniel, Robblee, James P., Lu, Hailong, Fagnant, Patricia M., Krementsova, Elena B., Trybus, Kathleen M., Houdusse, Anne, Volkmann, Niels, Hanein, Dorit

“…Plasmodium falciparum , the causative agent of malaria, moves by an atypical process called gliding motility. Actomyosin interactions are central to gliding…”
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Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design by Moussaoui, Dihia, Robblee, James P., Robert-Paganin, Julien, Auguin, Daniel, Fisher, Fabio, Fagnant, Patricia M., Macfarlane, Jill E., Schaletzky, Julia, Wehri, Eddie, Mueller-Dieckmann, Christoph, Baum, Jake, Trybus, Kathleen M., Houdusse, Anne

“…Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including…”
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A Perspective for Ménière's Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2 by Mom, Robin, Robert-Paganin, Julien, Mom, Thierry, Chabbert, Christian, Réty, Stéphane, Auguin, Daniel

“…Ménière's disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and…”
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Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets by Moussaoui, Dihia, Robblee, James P, Auguin, Daniel, Krementsova, Elena B, Haase, Silvia, Blake, Thomas CA, Baum, Jake, Robert-Paganin, Julien, Trybus, Kathleen M, Houdusse, Anne

“…Parasites from the genus Plasmodium are the causative agents of malaria. The mobility, infectivity, and ultimately pathogenesis of rely on a macromolecular…”
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Crystal structure of an EAL domain in complex with reaction product 5'-pGpG by Robert-Paganin, Julien, Nonin-Lecomte, Sylvie, Réty, Stéphane

“…FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic…”
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RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis by Loc'h, Jérôme, Blaud, Magali, Réty, Stéphane, Lebaron, Simon, Deschamps, Patrick, Bareille, Joseph, Jombart, Julie, Robert-Paganin, Julien, Delbos, Lila, Chardon, Florian, Zhang, Elodie, Charenton, Clément, Tollervey, David, Leulliot, Nicolas

“…During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to…”
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Dissecting Plasmodium falciparum myosin a function and regulation: the highway to develop novel antimalarial compounds by Robert-Paganin, Julien, Moussaoui, Dihia, Houdusse, Anne M.

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Allosteric modulators of force production: towards precision medicine for different classes of heart diseases by Houdusse, Anne, Robert-Paganin, Julien, Auguin, Daniel, Kikuti, Carlos

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Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition by Robert-Paganin, Julien, Auguin, Daniel, Houdusse, Anne

“…Hypertrophic cardiomyopathies (HCM) result from distinct single-point mutations in sarcomeric proteins that lead to muscle hypercontractility. While different…”
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Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy by Spudich, James A, Nandwani, Neha, Robert-Paganin, Julien, Houdusse, Anne, Ruppel, Kathleen M

“…Human β-cardiac myosin exists in an ON-state where both myosin heads are accessible for interaction with actin, and an OFF-state where the heads are folded…”
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Small molecules modulating force production: A new perspective against myosin-associated diseases by Auguin, Daniel, Moussaoui, Dihia, Robblee, James P., Kikuti, Carlos, Elena Sirkia, Maria, Canon, Louise, Robert-Paganin, Julien, Trybus, Kathleen M., Houdusse, Anne M.

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Cryo-EM structure of the folded-back state of human β-cardiac myosin by Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen, Spudich, James A., Houdusse, Anne M., Robert-Paganin, Julien

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