Search Results - "Robel, P"

Neurosteroids: beginning of the story by Baulieu, E E, Robel, P, Schumacher, M

“…Neurosteroids are synthetisized in the central and the peripheral nervous system, in glial cells, and also in neurons, from cholesterol or steroidal precursors…”
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Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids by Baulieu, E E, Robel, P

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Neurosteroids: Deficient Cognitive Performance in Aged Rats Depends on Low Pregnenolone Sulfate Levels in the Hippocampus by Vallée, M, Mayo, W, Darnaudéry, M, Corpéchot, C, Young, J, Koehl, M, Le Moal, M, Baulieu, E E, Robel, P, Simon, H

“…Pregnenolone sulfate (PREG S) is synthesized in the nervous system and is a major neurosteroid in the rat brain. Its concentrations were measured in the…”
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Neurosteroids, via σ Receptors, Modulate the [3H]norepinephrine Release Evoked by N-Methyl-D-Aspartate in the Rat Hippocampus by Monnet, François P., Mahé, Vincent, Robel, Paul, Baulieu, Etienne-Emile

“…N-Methyl-D-aspartate (NMDA, 200 μM) evokes the release of [3H]norepinephrine ([3H]NE) from preloaded hippocampal slices. This effect is potentiated by…”
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Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEAS) as Neuroactive Neurosteroids by Baulieu, Etienne-Emile, Robel, Paul

“…The description of dehydroepiandrosterone (DHEA) as a neurosteroid has triggered a vast body of pharmacological studies showing that DHEA and DHEA sulfate…”
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Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats by Corpéchot, C, Young, J, Calvel, M, Wehrey, C, Veltz, J N, Touyer, G, Mouren, M, Prasad, V V, Banner, C, Sjövall, J

“…A RIA procedure for measuring progesterone (PROG), 5 alpha-pregnane-3,20-dione (5 alpha-DH PROG), and 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha,5…”
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Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells by Jung-Testas, I, Hu, Z Y, Baulieu, E E, Robel, P

“…Cells dissociated from newborn rat forebrains were established in long term primary cultures. The cultures were made up almost exclusively of oligodendrocytes…”
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Brain neurosteroids during the mouse oestrous cycle by Corpéchot, C, Collins, B.E, Carey, M.P, Tsouros, A, Robel, P, Fry, J.P

“…Concentrations of the neuroactive steroid 3 α,5 α-tetrahydroprogesterone (TH PROG or allopregnanolone) and its precursors progesterone (PROG) and 5…”
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Neurosteroid metabolism : 7α-hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes by AKWA, Y, MORFIN, R. F, ROBEL, P, BAULIEU, E.-E

“…Two 'neurosteroids', dehydroepiandrosterone (DHEA) and pregnenolone (PREG), are converted by rat brain microsomes into polar metabolites, identified as the…”
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Biosynthesis and assay of neurosteroids in rats and mice: Functional correlates by Robel, P., Young, J., Corpéchot, C., Mayo, W., Perché, F., Haug, M., Simon, H., Baulieu, E.E.

“…Pregnenolone (PREG), synthesized de novo in rodent brain, is the precursor of PREG sulfate (S) and progesterone (PROG). PROG is further converted to…”
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Demonstration of progesterone receptors in rat Schwann cells by Jung-Testas, I., Schumacher, M., Robel, P., Baulieu, E.E.

“…We have recently shown that progesterone promotes myelin formation in peripheral nerves of rodents. In this study, we demonstrate the presence of progesterone…”
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Passage of progesterone into the brain changes with photoperiod in the ewe by Thiéry, J. C., Robel, P., Canepa, S., Delaleu, B., Gayrard, V., Picard-Hagen, N., Malpaux, B.

“…In this study we tested the hypothesis that photoperiod can modulate steroid access to the brain in a seasonal breeder. To this goal, we compared the passage…”
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Astrocytes and Neurosteroids: Metabolism of Pregnenolone and Dehydroepiandrosterone. Regulation by Cell Density by Akwa, Yvette, Sananès, Nicole, Gouézou, Monique, Robel, Paul, Baulieu, Etienne-Emile, Le Goascogne, Claude

“…The rat central nervous system (CNS) has previously been shown to synthesize pregnenolone (PREG) and convert it to progesterone (PROG) and 7α-hydroxy-PREG…”
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Neurosteroids: Oligodendrocyte Mitochondria Convert Cholesterol to Pregnenolone by Hu, Zong Yi, Bourreau, Eliane, Jung-Testas, Ingrid, Robel, Paul, Baulieu, Etienne-Emile

“…Oligodendrocyte mitochondria from 21-day-old Sprague-Dawley male rats were incubated with 100 nM [3H]cholesterol. It yielded [3H]pregnenolone at a rate of 2.5…”
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Anti-mullerian hormone produces endocrine sex reversal of fetal ovaries by Vigier, B, Forest, M.G, Eychenne, B, Bezard, J, Garrigou, O, Robel, P, Josso, N

“…We have previously reported that anti-Mullerian hormone (AMH), also known as Mullerian-inhibiting substance, the testicular glycoprotein involved in regression…”
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Progesterone and RU486: Opposing Effects on Human Sperm by Yang, Jing, Serres, Catherine, Philibert, Daniel, Robel, Paul, Baulieu, Etienne-Emile, Jouannet, Pierre

“…Progesterone induced a rapid influx of calcium in capacitated human sperm, followed by a long-lasting, dose-dependent increase of intracellular free calcium…”
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Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain by Akwa, Y, Young, J, Kabbadj, K, Sancho, M J, Zucman, D, Vourc'h, C, Jung-Testas, I, Hu, Z Y, Le Goascogne, C, Jo, D H

“…Pregnenolone (P) and dehydroepiandrosterone (D) accumulate in the brain as unconjugated steroids and their sulfate (S) and fatty acid (L) esters. The…”
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Actions of steroid hormones- and growth factors on glial cells of the central and peripheral nervous system by Jung-Testas, I, Schumacher, M, Robel, P, Baulieu, E E

“…Primary cultures of oligodendrocytes and astrocytes and purified cultures of Schwann cells were prepared respectively from forebrain and sciatic nerves of…”
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The neurosteroid progesterone increases the expression of myelin proteins (MBP and CNPase) in rat oligodendrocytes in primary culture by Jung-Testas, I, Schumacher, M, Robel, P, Baulieu, E E

“…Steroid hormones are known to act in the central nervous system (CNS), affecting brain development and behavior. They have profound influences on the growth,…”
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A Progesterone Metabolite Stimulates the Release of Gonadotropin-Releasing Hormone from GT1-1 Hypothalamic Neurons via the γ-Aminobutyric Acid Type A Receptor by El-Etr, Martine, Akwa, Yvette, Fiddes, Rodney J., Robel, Paul, Baulieu, Etienne-Emile

“…The reduced progesterone metabolite tetrahydroprogesterone (3α-hydroxy-5α-pregnan-20-one; 3α,5α-THP) is a positive modulator of the γ-aminobutyric acid type A…”
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