Search Results - "Robbs, Bruno K."

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis by Sant’Anna, Ricardo, Robbs, Bruno K., de Freitas, Júlia Araújo, dos Santos, Patrícia Pires, König, Annekatrin, Outeiro, Tiago Fleming, Foguel, Debora

“…Abstract Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading…”
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Extracellular alpha-synuclein: Sensors, receptors, and responses by Domingues, Renato, Sant’Anna, Ricardo, da Fonseca, Anna Carolina Carvalho, Robbs, Bruno K., Foguel, Debora, Outeiro, Tiago F.

“…Synucleinopathies are a group of progressive neurodegenerative diseases known for the accumulation of insoluble aggregates containing the protein…”
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A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update by Machado, Thaíssa Q., da Fonseca, Anna C. C., Duarte, Allana B. S., Robbs, Bruno K., de Sousa, Damião P.

“…Monoterpenes are a group of natural products that have been widely studied due to their therapeutic potential against various pathologies. These compounds are…”
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Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells by ACCIOLY, Maria T, PACHECO, Patricia, MAYA-MONTEIRO, Clarissa M, CARROSSINI, Nina, ROBBS, Bruno K, OLIVEIRA, Silvia S, KAUFMANN, Cristiane, MORGADO-DIAZ, José A, BOZZA, Patricia T, VIOLA, Joao P. B

“…Lipid bodies (lipid droplets) are emerging as dynamic organelles involved in lipid metabolism and inflammation. Increased lipid body numbers have been…”
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Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma by Silva, Rayanne H N, Machado, Thaíssa Q, da Fonseca, Anna Carolina C, Tejera, Eduardo, Perez-Castillo, Yunierkis, Robbs, Bruno K, de Sousa, Damião P

“…Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment…”
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Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling by de Souza, Waldemir F, Fortunato-Miranda, Natalia, Robbs, Bruno K, de Araujo, Wallace M, de-Freitas-Junior, Julio C, Bastos, Lilian G, Viola, João P B, Morgado-Díaz, José A

“…The altered expressions of claudin proteins have been reported during the tumorigenesis of colorectal cancer. However, the molecular mechanisms that regulate…”
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Dual Roles for NFAT Transcription Factor Genes as Oncogenes and Tumor Suppressors by Robbs, Bruno K., Cruz, Andre L. S., Werneck, Miriam B. F., Mognol, Giuliana P., Viola, João P. B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells by Macedo, Arthur L., da Silva, Diego P.D., Moreira, Davyson L., de Queiroz, Lucas N., Vasconcelos, Thatyana R.A., Araujo, Geisoellen F., Kaplan, Maria Auxiliadora C., Pereira, Suiane S.C., de Almeida, Elan C.P., Valverde, Alessandra L., Robbs, Bruno K.

“…[Display omitted] Oral squamous cell carcinoma (OSCC) is one of the ten most common types of cancer worldwide. Plants of the genusPiper are used in traditional…”
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Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements by Mognol, Giuliana P., de Araujo-Souza, Patricia S., Robbs, Bruno K., Teixeira, Leonardo K., Viola, Joao P.B.

“…A number of physiological processes in both normal and cancer cells are regulated by the proto-oncogene c-Myc. Among them, processes such as cell cycle…”
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NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death by Faget, Douglas V, Lucena, Pedro I, Robbs, Bruno K, Viola, João P B

“…The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes…”
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An alternative, easy and reproducible method of stabilization and ligature-induced periodontitis in mouse by Pereira, Suiane S.C., Araujo, Geisoellen F., de Queiroz, Lucas N., Câmara, Priscilla R., Pascoal, Vinícius D.B., Azevedo, Rebeca S., Robbs, Bruno K.

“…[Display omitted] Periodontal disease is one of the most common causes of tooth loss in the world. Ligature-induced is the most used method to study…”
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The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK/ERK pathway and upregulation of TNF-α expression by Robbs, Bruno K., Lucena, Pedro I., Viola, João P.B.

“…Nuclear factor of activated T cells (NFAT) was described as an activation and differentiation factor in T cells. NFAT1 protein is expressed in several cell…”
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Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma by Borges, Amanda A, de Souza, Michele P, da Fonseca, Anna Carolina C, Wermelinger, Guilherme F, Ribeiro, Ruan C B, Amaral, Adriane A P, de Carvalho, Cláudio José C, Abreu, Lucas S, de Queiroz, Lucas Nicolau, de Almeida, Elan C P, Rabelo, Vitor W, Abreu, Paula A, Pontes, Bruno, Ferreira, Vitor F, da Silva, Fernando de C, Forezi, Luana da S M, Robbs, Bruno K

“…Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for approximately 90% of all oral cancers, and is the eighth most common…”
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Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma by Cavalcanti Chipoline, Ingrid, Carolina Carvalho da Fonseca, Anna, Ribeiro Machado da Costa, Gabriella, Pereira de Souza, Michele, Won-Held Rabelo, Vitor, de Queiroz, Lucas N., Luiz Ferraz de Souza, Theo, Cardozo Paes de Almeida, Elan, Alvarez Abreu, Paula, Pontes, Bruno, Francisco Ferreira, Vitor, de Carvalho da Silva, Fernando, Robbs, Bruno K.

“…[Display omitted] •Thirty-five new compounds of triazole naphthoquinones were synthesized.•Compounds 16a, 16b and 16 g were able to induce cytotoxicity in…”
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NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains by Lucena, Pedro I., Faget, Douglas V., Pachulec, Emilia, Robaina, Marcela C., Klumb, Claudete E., Robbs, Bruno K., Viola, João P. B.

“…The NFAT (nuclear factor of activated T cells) family of transcription factors is composed of four calcium-responsive proteins (NFAT1 to -4). The NFAT2 (also…”
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TGF-β acts as a dual regulator of COX-2/PGE 2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/β-catenin pathways in colorectal cancer cells by de Araújo, Wallace M, Tanaka, Marcelo N, Lima, Pedro H S, de Moraes, Cassio F, Leve, Fernanda, Bastos, Lilian G, Rocha, Murilo R, Robbs, Bruno K, Viola, João P B, Morgado-Diaz, Jose A

“…Transforming growth factor-β (TGF-β) plays a dual role acting as tumor promoter or suppressor. Along with cyclooxygenase-2 (COX-2) and oncogenic Ras, this…”
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TGF‐β acts as a dual regulator of COX‐2/PGE2 tumor promotion depending of its cross‐interaction with H‐Ras and Wnt/β‐catenin pathways in colorectal cancer cells by Araújo, Wallace M., Tanaka, Marcelo N., Lima, Pedro H. S., Moraes, Cassio F., Leve, Fernanda, Bastos, Lilian G., Rocha, Murilo R., Robbs, Bruno K., Viola, João P. B., Morgado‐Diaz, Jose A.

“…Transforming growth factor‐β (TGF‐β) plays a dual role acting as tumor promoter or suppressor. Along with cyclooxygenase‐2 (COX‐2) and oncogenic Ras, this…”
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Potential cytotoxic and selective effect of new benzo[b]xanthenes against oral squamous cell carcinoma by Zorzanelli, Bruna C, de Queiroz, Lucas N, Santos, Raíssa Ma, Menezes, Luiza M, Gomes, Fernanda C, Ferreira, Vitor F, C da Silva, Fernando de, Robbs, Bruno K

“…The current work shows a new synthetic methodology to obtain 21 naphthoquinones that have been evaluated against oral cavity cancer. The compounds were…”
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IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation by Teixeira, Leonardo K, Fonseca, Bruna P F, Vieira-de-Abreu, Adriana, Barboza, Bianca A, Robbs, Bruno K, Bozza, Patrícia T, Viola, João P B

“…CD8+ T lymphocytes are excellent sources of IFN-gamma; however, the molecular mechanisms that dictate IFN-gamma expression upon TCR stimulation in these cells…”
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Controlling beta -Amyloid Oligomerization by the Use of Naphthalene Sulfonates: TRAPPING LOW MOLECULAR WEIGHT OLIGOMERIC SPECIES by Ferrao-Gonzales, Astria D, Robbs, Bruno K, Moreau, Vitor Hugo, Ferreira, Aricele, Juliano, Luiz, Valente, Ana Paula, Almeida, Fabio CL, Silva, Jerson L, Foguel, Debora

“…Aggregation of proteins and peptides has been shown to be responsible for several diseases known as amyloidoses, which include Alzheimer disease (AD), prion…”
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