Search Results - "Robbins, Stephen M"

The SPFH domain-containing proteins: more than lipid raft markers by Browman, Duncan T, Hoegg, Maja B, Robbins, Stephen M

“…Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a potential mechanism for compartmentalizing cellular functions within…”
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A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus by Pilsczek, Florian H, Salina, Davide, Poon, Karen K H, Fahey, Candace, Yipp, Bryan G, Sibley, Christopher D, Robbins, Stephen M, Green, Francis H Y, Surette, Mike G, Sugai, Motoyuki, Bowden, M Gabriela, Hussain, Muzaffar, Zhang, Kunyan, Kubes, Paul

“…Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune…”
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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma by Beug, Shawn T., Beauregard, Caroline E., Healy, Cristin, Sanda, Tarun, St-Jean, Martine, Chabot, Janelle, Walker, Danielle E., Mohan, Aditya, Earl, Nathalie, Lun, Xueqing, Senger, Donna L., Robbins, Stephen M., Staeheli, Peter, Forsyth, Peter A., Alain, Tommy, LaCasse, Eric C., Korneluk, Robert G.

“…Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously…”
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Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida by Li, Shu Shun, Ogbomo, Henry, Mansour, Michael K., Xiang, Richard F., Szabo, Lian, Munro, Fay, Mukherjee, Priyanka, Mariuzza, Roy A., Amrein, Matthias, Vyas, Jatin M., Robbins, Stephen M., Mody, Christopher H.

“…Natural killer (NK) cells use the activating receptor NKp30 as a microbial pattern-recognition receptor to recognize, activate cytolytic pathways, and directly…”
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Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo by Deng, Jingti, Koutras, Carolina, Donnelier, Julien, Alshehri, Mana, Fotouhi, Maryam, Girard, Martine, Casha, Steve, McPherson, Peter S., Robbins, Stephen M., Braun, Janice E. A.

“…The fidelity of synaptic transmission depends on the integrity of the protein machinery at the synapse. Unfolded synaptic proteins undergo refolding or…”
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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors by Ahmad, Shiekh Tanveer, Rogers, Alexandra D., Chen, Myra J., Dixit, Rajiv, Adnani, Lata, Frankiw, Luke S., Lawn, Samuel O., Blough, Michael D., Alshehri, Mana, Wu, Wei, Marra, Marco A., Robbins, Stephen M., Cairncross, J. Gregory, Schuurmans, Carol, Chan, Jennifer A.

“…Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its cancer link, little is known of Cic’s function in the…”
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PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils by Kubes, Paul, Heit, Bryan, Robbins, Stephen M, Downey, Charlene M, Guan, Zhiwen, Colarusso, Pina, Miller, B Joan, Jirik, Frank R

“…Leukocytes sense and move in the direction of chemoattractants. Kubes and colleagues show that the phosphatase PTEN is required by migrating neutrophils to…”
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The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients by Li, Shu Shun, Kyei, Stephen K., Timm-McCann, Martina, Ogbomo, Henry, Jones, Gareth J., Shi, Meiqing, Xiang, Richard F., Oykhman, Paul, Huston, Shaunna M., Islam, Anowara, Gill, M. John, Robbins, Stephen M., Mody, Christopher H.

“…Natural killer (NK) cells are a subset of immune effectors that directly bind and kill fungi via a perforin-dependent mechanism. The receptor mediating this…”
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Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments by Shen, Yaoqing, Grisdale, Cameron J., Islam, Sumaiya A., Bose, Pinaki, Lever, Jake, Zhao, Eric Y., Grinshtein, Natalie, Ma, Yussanne, Mungall, Andrew J., Moore, Richard A., Lun, Xueqing, Senger, Donna L., Robbins, Stephen M., Wang, Alice Yijun, MacIsaac, Julia L., Kobor, Michael S., Luchman, H. Artee, Weiss, Samuel, Chan, Jennifer A., Blough, Michael D., Kaplan, David R., Cairncross, J. Gregory, Marra, Marco A., Jones, Steven J. M.

“…Glioblastoma multiforme (GBM) is the most deadly brain tumor, and currently lacks effective treatment options. Brain tumor-initiating cells (BTICs) and…”
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Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation by Nguyen, Stephanie A, Stechishin, Owen D M, Luchman, H Artee, Lun, Xueqing Q, Senger, Donna L, Robbins, Stephen M, Cairncross, J Gregory, Weiss, Samuel

“…The current standard of care for glioblastoma (GBM) involves a combination of surgery, radiotherapy, and temozolomide chemotherapy, but this regimen fails to…”
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Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19) by Somayaji, Ranjani, Luke, David R, Lau, Arthur, Guner, Rahmet, Tabak, Ŏ Fehmi, Hepokoski, Mark, Gardetto, Nancy, Conrad, Steven A, Kumar, Sunil D, Ghosh, Kalyan, Robbins, Stephen M, Senger, Donna L, Sun, Daisy, Lim, Rachel K S, Liu, Jonathan, Eser, Fatma, Karaali, Ridvan, Tremblay, Alain, Muruve, Daniel

“…ObjectiveDipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a…”
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To promote or inhibit glioma progression, that is the question for IL-33 by Robbins, Stephen M, Senger, Donna L

“…IL-33, a member of the IL-1 cytokine family has been shown to play a dual role within the body. First IL-33, similar to other IL-1 family members, is a…”
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Lipoteichoic acid induces unique inflammatory responses when compared to other toll-like receptor 2 ligands by Long, Elizabeth M, Millen, Brandie, Kubes, Paul, Robbins, Stephen M

“…Toll-like receptors (TLRs) recognize evolutionarily-conserved molecular patterns originating from invading microbes. In this study, we were interested in…”
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The p75 neurotrophin receptor is a central regulator of glioma invasion by Johnston, Angela L M, Lun, Xueqing, Rahn, Jennifer J, Liacini, Abdelhamid, Wang, Limei, Hamilton, Mark G, Parney, Ian F, Hempstead, Barbara L, Robbins, Stephen M, Forsyth, Peter A, Senger, Donna L

“…The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional…”
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Immune Cell Toll-Like Receptor 4 Is Required for Cardiac Myocyte Impairment During Endotoxemia by Tavener, Samantha A, Long, Elizabeth M, Robbins, Stephen M, McRae, Krista M, Van Remmen, Holly, Kubes, Paul

“…The aim of this study was to investigate the importance of Toll-like receptor 4 (TLR4) signaling on cardiac myocytes versus immune cells in lipopolysaccharide…”
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TLR4 Contributes to Disease-Inducing Mechanisms Resulting in Central Nervous System Autoimmune Disease by Kerfoot, Steven M, Long, Elizabeth M, Hickey, Michael J, Andonegui, Graciela, Lapointe, Benoit M, Zanardo, Renata C. O, Bonder, Claudine, James, Will G, Robbins, Stephen M, Kubes, Paul

“…Environmental factors strongly influence the development of autoimmune diseases, including multiple sclerosis. Despite this clear association, the mechanisms…”
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Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor by Wang, LiMei, Rahn, Jennifer J, Lun, XueQing, Sun, Beichen, Kelly, John J P, Weiss, Samuel, Robbins, Stephen M, Forsyth, Peter A, Senger, Donna L

“…The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of…”
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Distinct Regions within the Erlins Are Required for Oligomerization and Association with High Molecular Weight Complexes by Hoegg, Maja B., Browman, Duncan T., Resek, Mary E., Robbins, Stephen M.

“…The group of stomatin/prohibitin/flotillin/HflK/C (SPFH) domain-containing proteins comprise members of diverse subcellular localization and function…”
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subclass of acylated anti-inflammatory mediators usurp Toll-like receptor 2 to inhibit neutrophil recruitment through peroxisome proliferator-activated receptor γ by Long, Elizabeth M, Klimowicz, Alexander C, Paula-Neto, Heitor A, Millen, Brandie, McCafferty, Donna-Marie, Kubes, Paul, Robbins, Stephen M

“…Toll-like receptors are host sentinel receptors that signal the presence of infectious nonself and initiate protective immunity. One of the primary immune…”
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Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line by Zaman, Sabiha N., Resek, Mary E., Robbins, Stephen M.

“…Chemokines play pivotal roles in regulating a wide variety of biological processes by modulating cell migration and recruitment. Deregulation of chemokine…”
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