Search Results - "Robbins, Robert C."

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells by Lan, Feng, Lee, Andrew S., Liang, Ping, Sanchez-Freire, Veronica, Nguyen, Patricia K., Wang, Li, Han, Leng, Yen, Michelle, Wang, Yongming, Sun, Ning, Abilez, Oscar J., Hu, Shijun, Ebert, Antje D., Navarrete, Enrique G., Simmons, Chelsey S., Wheeler, Matthew, Pruitt, Beth, Lewis, Richard, Yamaguchi, Yoshinori, Ashley, Euan A., Bers, Donald M., Robbins, Robert C., Longaker, Michael T., Wu, Joseph C.

“…Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked to arrhythmia and sudden cardiac death. While the causes of HCM…”
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Drug Screening Using a Library of Human Induced Pluripotent Stem Cell―Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity by PING LIANG, FENG LAN, NGUYEN, Patricia K, BERS, Donald M, ROBBINS, Robert C, WU, Joseph C, LEE, Andrew S, TINGYU GONG, SANCHEZ-FREIRE, Veronica, YONGMING WANG, DIECKE, Sebastian, SALLAM, Karim, KNOWLES, Joshua W, WANG, Paul J

“…Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of…”
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A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation by Khatri, Purvesh, Roedder, Silke, Kimura, Naoyuki, De Vusser, Katrien, Morgan, Alexander A, Gong, Yongquan, Fischbein, Michael P, Robbins, Robert C, Naesens, Maarten, Butte, Atul J, Sarwal, Minnie M

“…Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples) from four organs, we identified a common rejection module (CRM)…”
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MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease by SHIJUN HU, MEI HUANG, ROBBINS, Robert C, WU, Joseph C, ZONGJIN LI, FANGJUN JIA, ZHUMUR GHOSH, LIJKWAN, Maarten A, FASANARO, Pasquale, NING SUN, XI WANG, MARTELLI, Fabio

“…MicroRNAs are involved in various critical functions, including the regulation of cellular differentiation, proliferation, angiogenesis, and apoptosis. We…”
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Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells by Sun, Ning, Panetta, Nicholas J, Gupta, Deepak M, Wilson, Kitchener D, Lee, Andrew, Jia, Fangjun, Hu, Shijun, Cherry, Athena M, Robbins, Robert C, Longaker, Michael T, Wu, Joseph C

“…Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the…”
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Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells by Narsinh, Kazim H, Sun, Ning, Sanchez-Freire, Veronica, Lee, Andrew S, Almeida, Patricia, Hu, Shijun, Jan, Taha, Wilson, Kitchener D, Leong, Denise, Rosenberg, Jarrett, Yao, Mylene, Robbins, Robert C, Wu, Joseph C

“…Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are promising candidate cell sources for regenerative medicine. However,…”
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Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy by Sun, Ning, Yazawa, Masayuki, Liu, Jianwei, Han, Leng, Sanchez-Freire, Veronica, Abilez, Oscar J, Navarrete, Enrique G, Hu, Shijun, Wang, Li, Lee, Andrew, Pavlovic, Aleksandra, Lin, Shin, Chen, Rui, Hajjar, Roger J, Snyder, Michael P, Dolmetsch, Ricardo E, Butte, Manish J, Ashley, Euan A, Longaker, Michael T, Robbins, Robert C, Wu, Joseph C

“…Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure, dilated cardiomyopathy (DCM) is the most common form of…”
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Local MicroRNA Modulation Using a Novel Anti-miR-21–Eluting Stent Effectively Prevents Experimental In-Stent Restenosis by Wang, Dong, Deuse, Tobias, Stubbendorff, Mandy, Chernogubova, Ekaterina, Erben, Reinhold G, Eken, Suzanne M, Jin, Hong, Li, Yuhuang, Busch, Albert, Heeger, Christian-H, Behnisch, Boris, Reichenspurner, Hermann, Robbins, Robert C, Spin, Joshua M, Tsao, Philip S, Schrepfer, Sonja, Maegdefessel, Lars

“…OBJECTIVE—Despite advances in stent technology for vascular interventions, in-stent restenosis (ISR) because of myointimal hyperplasia remains a major…”
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Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors by Wu, Joseph C, Narsinh, Kazim H, Jia, Fangjun, Robbins, Robert C, Kay, Mark A, Longaker, Michael T

“…Human induced pluripotent stem cells (hiPSCs) derived from patient samples have tremendous potential for innovative approaches to disease pathology…”
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Novel MicroRNA Prosurvival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation by SHIJUN HU, MEI HUANG, WU, Joseph C, NGUYEN, Patricia K, YONGQUAN GONG, ZONGJIN LI, FANGJUN JIA, FENG LAN, JUNWEI LIU, NAG, Divya, ROBBINS, Robert C

“…Although stem cell therapy has provided a promising treatment for myocardial infarction, the low survival of the transplanted cells in the infarcted myocardium…”
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Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells by Deuse, Tobias, Stubbendorff, Mandy, Tang-Quan, Karis, Phillips, Neil, Kay, Mark A, Eiermann, Thomas, Phan, Thang T, Volk, Hans-Dieter, Reichenspurner, Hermann, Robbins, Robert C, Schrepfer, Sonja

“…We here present an immunologic head-to-head comparison between human umbilical cord lining mesenchymal stem cells (clMSCs) and adult bone marrow MSCs (bmMSCs)…”
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Immunosuppressive Therapy Mitigates Immunological Rejection of Human Embryonic Stem Cell Xenografts by Swijnenburg, Rutger-Jan, Schrepfer, Sonja, Govaert, Johannes A., Cao, Feng, Ransohoff, Katie, Sheikh, Ahmad Y., Haddad, Munif, Connolly, Andrew J., Davis, Mark M., Robbins, Robert C., Wu, Joseph C.

“…Given their self-renewing and pluripotent capabilities, human embryonic stem cells (hESCs) are well poised as a cellular source for tissue regeneration…”
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Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell-Based Myocardial Salvage After Acute Myocardial Infarction by DEUSE, Tobias, PETER, Christoph, SCHREPFER, Sonja, FEDAK, Paul W. M, DOYLE, Tim, REICHENSPURNER, Hermann, ZIMMERMANN, Wolfram H, ESCHENHAGEN, Thomas, STEIN, William, WU, Joseph C, ROBBINS, Robert C

“…Mesenchymal stem cell (MSC)-based regenerative strategies were investigated to treat acute myocardial infarction and improve left ventricular function. Murine…”
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Imaging Survival and Function of Transplanted Cardiac Resident Stem Cells by Li, Zongjin, MD, PhD, Lee, Andrew, BS, Huang, Mei, PhD, Chun, Hyung, MD, Chung, Jaehoon, MD, Chu, Pauline, MS, Hoyt, Grant, BS, Yang, Phillip, MD, PhD, Rosenberg, Jarrett, PhD, Robbins, Robert C., MD, Wu, Joseph C., MD, PhD

“…Objectives The goal of this study is to characterize resident cardiac stem cells (CSCs) and investigate their therapeutic efficacy in myocardial infarction by…”
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miR-29b Participates in Early Aneurysm Development in Marfan Syndrome by Merk, Denis R, Chin, Jocelyn T, Dake, Benjamin A, Maegdefessel, Lars, Miller, Miquell O, Kimura, Naoyuki, Tsao, Philip S, Iosef, Cristiana, Berry, Gerald J, Mohr, Friedrich W, Spin, Joshua M, Alvira, Cristina M, Robbins, Robert C, Fischbein, Michael P

“…RATIONALE:Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent…”
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Effects of cell number on teratoma formation by human embryonic stem cells by Lee, Andrew S., Tang, Chad, Cao, Feng, Xie, Xiaoyan, van der Bogt, Koen, Hwang, Andrew, Connolly, Andrew J., Robbins, Robert C., Wu, Joseph C.

“…Teratoma formation is a critical obstacle to safe clinical translation of human embryonic stem (ES) cell-based therapies in the future. As current methods of…”
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Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium by Robbins, Robert C, Balsam, Leora B, Wagers, Amy J, Christensen, Julie L, Kofidis, Theo, Weissman, Irving L

“…Under conditions of tissue injury, myocardial replication and regeneration have been reported. A growing number of investigators have implicated adult bone…”
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Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes by Cao, Feng, Wagner, Roger A, Wilson, Kitchener D, Xie, Xiaoyan, Fu, Ji-Dong, Drukker, Micha, Lee, Andrew, Li, Ronald A, Gambhir, Sanjiv S, Weissman, Irving L, Robbins, Robert C, Wu, Joseph C

“…Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we…”
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SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts by Deuse, Tobias, Wang, Dong, Stubbendorff, Mandy, Itagaki, Ryo, Grabosch, Antje, Greaves, Laura C., Alawi, Malik, Grünewald, Anne, Hu, Xiaomeng, Hua, Xiaoqin, Velden, Joachim, Reichenspurner, Hermann, Robbins, Robert C., Jaenisch, Rudolf, Weissman, Irving L., Schrepfer, Sonja

“…The generation of pluripotent stem cells by somatic cell nuclear transfer (SCNT) has recently been achieved in human cells and sparked new interest in this…”
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Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum by Wystrychowski, Wojciech, Patlolla, Bhagat, Zhuge, Yan, Neofytou, Evgenios, Robbins, Robert C, Beygui, Ramin E

“…Acute myocardial infarction (MI) leads to an irreversible loss of proper cardiac function. Application of stem cell therapy is an attractive option for MI…”
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