Search Results - "Robbins, Paul D"

The Clinical Potential of Senolytic Drugs by Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

“…Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in…”
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Regulation of chronic inflammatory and immune processes by extracellular vesicles by Robbins, Paul D, Dorronsoro, Akaitz, Booker, Cori N

“…Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a…”
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Cellular senescence: a key therapeutic target in aging and diseases by Zhang, Lei, Pitcher, Louise E, Yousefzadeh, Matthew J, Niedernhofer, Laura J, Robbins, Paul D, Zhu, Yi

“…Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can…”
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Gene Delivery to Joints by Intra-Articular Injection by Evans, Christopher H, Ghivizzani, Steven C, Robbins, Paul D

“…Most forms of arthritis are incurable, difficult to treat, and a major cause of disability in Western countries. Better local treatment of arthritis is…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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Nuclear Genomic Instability and Aging by Niedernhofer, Laura J, Gurkar, Aditi U, Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J, Robbins, Paul D

“…The nuclear genome decays as organisms age. Numerous studies demonstrate that the burden of several classes of DNA lesions is greater in older mammals than in…”
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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Identification of HSP90 inhibitors as a novel class of senolytics by Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.

“…Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to…”
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Cellular senescence mediates fibrotic pulmonary disease by Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence…”
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Role of Cellular Senescence in Type II Diabetes by Narasimhan, Akilavalli, Flores, Rafael R, Robbins, Paul D, Niedernhofer, Laura J

“…Cellular senescence is a cell fate that occurs in response to numerous types of stress and can promote tissue repair or drive inflammation and disruption of…”
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Cell-type specific penetrating peptides: therapeutic promises and challenges by Zahid, Maliha, Robbins, Paul D

“…Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptides able to carry peptides, proteins, nucleic acid, and…”
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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors by Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.

“…Summary Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven bioinformatics‐based approach, we recently identified pro‐survival…”
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SIRT1 negatively regulates the mammalian target of rapamycin by Ghosh, Hiyaa Singhee, McBurney, Michael, Robbins, Paul D

“…The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+…”
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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice by Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.

“…Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of…”
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Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes by Garcia-Contreras, Marta, Shah, Sanket H., Tamayo, Alejandro, Robbins, Paul D., Golberg, Ronald B., Mendez, Armando J., Ricordi, Camillo

“…Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-producing ß cells which leads to chronic hyperglycemia. Exosomes are…”
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Immune Senescence, Immunosenescence and Aging by Lee, Kyoo-A, Flores, Rafael R, Jang, In Hwa, Saathoff, Ashley, Robbins, Paul D

“…With aging, there is increased dysfunction of both innate and adaptive immune responses, which contributes to impaired immune responses to pathogens and…”
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis by Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep

“…Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in…”
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Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome by Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, Chih‐Yi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura J., Robbins, Paul D., Huard, Johnny

“…Hutchinson–Gilford progeria syndrome (HGPS) is caused by the accumulation of mutant prelamin A (progerin) in the nuclear lamina, resulting in increased nuclear…”
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Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model by Yang, Chenjie, Kim, Seon-Hee, Bianco, Nicole R, Robbins, Paul D

“…Exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. Tumor-derived exosomes usually contain tumor…”
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Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells by Yang, Chenjie, Chalasani, Geetha, Ng, Yue-Harn, Robbins, Paul D

“…Mycoplasmas cause numerous human diseases and are common opportunistic pathogens in cancer patients and immunocompromised individuals. Mycoplasma infection…”
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