Search Results - "Robbins, Jonathan A"

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle by Favuzza, Paola, de Lera Ruiz, Manuel, Thompson, Jennifer K., Triglia, Tony, Ngo, Anna, Steel, Ryan W.J., Vavrek, Marissa, Christensen, Janni, Healer, Julie, Boyce, Christopher, Guo, Zhuyan, Hu, Mengwei, Khan, Tanweer, Murgolo, Nicholas, Zhao, Lianyun, Penington, Jocelyn Sietsma, Reaksudsan, Kitsanapong, Jarman, Kate, Dietrich, Melanie H., Richardson, Lachlan, Guo, Kai-Yuan, Lopaticki, Sash, Tham, Wai-Hong, Rottmann, Matthias, Papenfuss, Tony, Robbins, Jonathan A., Boddey, Justin A., Sleebs, Brad E., Sabroux, Hélène Jousset, McCauley, John A., Olsen, David B., Cowman, Alan F.

“…Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmodium. However, increased…”
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An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites by Absalon, Sabrina, Robbins, Jonathan A., Dvorin, Jeffrey D.

“…Blood-stage replication of the human malaria parasite Plasmodium falciparum occurs via schizogony, wherein daughter parasites are formed by a specialized…”
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Acute and Chronic Effects of Rifampin on Letermovir Suggest Transporter Inhibition and Induction Contribute to Letermovir Pharmacokinetics by Robbins, Jonathan A., Menzel, Karsten, Lassman, Michael, Zhao, Tian, Fancourt, Craig, Chu, Xiaoyan, Mostoller, Kate, Witter, Rose, Marceau West, Rachel, Stoch, S. Aubrey, McCrea, Jacqueline B., Iwamoto, Marian

“…Rifampin has acute inhibitory and chronic inductive effects that can cause complex drug–drug interactions. Rifampin inhibits transporters including…”
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An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition by Ondracka, Andrej, Robbins, Jonathan A, Cross, Frederick R

“…B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the…”
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Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-ranging trial by Robbins, Jonathan A., Tait, Dereck, Huang, Qinlei, Dubey, Sheri, Crumley, Tami, Cote, Josee, Luk, Julie, Sachs, Jeffrey R., Rutkowski, Kathryn, Park, Harriet, Schwab, Robert, Howitt, William Joseph, Rondon, Juan Carlos, Hernandez-Illas, Martha, O'Reilly, Terry, Smith, William, Simon, Jakub, Hardalo, Cathy, Zhao, Xuemei, Wnek, Richard, Cope, Alethea, Lai, Eseng, Annunziato, Paula, Guris, Dalya, Stoch, S. Aubrey

“…Vaccines against COVID-19 are needed to overcome challenges associated with mitigating the global pandemic. We report the safety and immunogenicity of V590, a…”
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Requirements and reasons for effective inhibition of the anaphase promoting complex activator CDH1 by Robbins, Jonathan A, Cross, Frederick R

“…Anaphase promoting complex (APC)-Cdh1 targets multiple mitotic proteins for degradation upon exit from mitosis into G1; inhibitory phosphorylation of Cdh1 by…”
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Regulated degradation of the APC coactivator Cdc20 by Robbins, Jonathan A, Cross, Frederick R

“…Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of…”
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Evaluation of the inhibitory effects of itraconazole on letermovir by McCrea, Jacqueline B., Menzel, Karsten, Fancourt, Craig, Witter, Rose, Zhao, Tian, Robbins, Jonathan A., Stoch, S. Aubrey, Iwamoto, Marian

“…Aims Letermovir, a cytomegalovirus (CMV) DNA terminase complex inhibitor, is a substrate of ABCB1 (P‐glycoprotein; P‐gp), organic anion transporting…”
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The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum by Robbins, Jonathan A, Absalon, Sabrina, Streva, Vincent A, Dvorin, Jeffrey D

“…All well-studied eukaryotic cell cycles are driven by cyclins, which activate cyclin-dependent kinases (CDKs), and these protein kinase complexes are viable…”
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Administration of abciximab to patients receiving tirofiban or eptifibatide: effect on platelet function by Lev, Eli I, Osende, Julio I, Richard, Merwin F, Robbins, Jonathan A, Delfin, Jenny A, Rodriguez, Oswaldo, Sharma, Samin K, Jayasundera, Tim, Badimon, Juan J, Marmur, Jonathan D

“…OBJECTIVES The goal of this study was to evaluate platelet function and to preliminarily assess the clinical safety of sequential treatment with tirofiban or…”
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The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage italic toggle="yes">Plasmodium falciparum /italic by Jonathan A. Robbins, Sabrina Absalon, Vincent A. Streva, Jeffrey D. Dvorin

“…ABSTRACT All well-studied eukaryotic cell cycles are driven by cyclins, which activate cyclin-dependent kinases (CDKs), and these protein kinase complexes are…”
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A Chromatin Immunoprecipitation Screen Reveals Protein Kinase Cβ as a Direct RUNX1 Target Gene by Hug, Bruce A., Ahmed, Nazia, Robbins, Jonathan A., Lazar, Mitchell A.

“…RUNX1 (also known as AML1) is a DNA-binding transcription factor that functions as a tumor suppressor and developmental determinant in hematopoietic cells…”
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The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression by Wäsch, R, Robbins, J A, Cross, F R

“…Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to…”
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A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene by Hug, Bruce A, Ahmed, Nazia, Robbins, Jonathan A, Lazar, Mitchell A

“…RUNX1 (also known as AML1) is a DNA-binding transcription factor that functions as a tumor suppressor and developmental determinant in hematopoietic cells…”
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A Chromatin Immunoprecipitation Screen Reveals Protein Kinase Cβ as a Direct RUNX1 Target Gene by Bruce A. Hug, Nazia Ahmed, Jonathan A. Robbins, Mitchell A. Lazar

“…RUNX1 (also known as AML1) is a DNA-binding transcription factor that functions as a tumor suppressor and developmental determinant in hematopoietic cells…”
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