Search Results - "Robbins, Gregory R"

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases by Robbins, Gregory R., Wen, Haitao, Ting, Jenny P.-Y.

“…Modern medical and hygienic practices have greatly improved human health and longevity; however, increased human life span occurs concomitantly with the…”
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Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells by Fromen, Catherine A., PhD, Rahhal, Tojan B., BS, Robbins, Gregory R., PhD, Kai, Marc P., PhD, Shen, Tammy W., PhD, Luft, J. Christopher, PhD, DeSimone, Joseph M., PhD

“…Abstract Engineered nanoparticles have the potential to expand the breadth of pulmonary therapeutics, especially as respiratory vaccines. Notably, cationic…”
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Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization by Fromen, Catherine A., Robbins, Gregory R., Shen, Tammy W., Kai, Marc P., Ting, Jenny P. Y., DeSimone, Joseph M.

“…Significance To our knowledge, no other nano-based vaccine delivery platform has directly assessed the effects of nanoparticle charge on pulmonary vaccination…”
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Nanoparticle clearance is governed by Th1/Th2 immunity and strain background by Jones, Stephen W, Roberts, Reid A, Robbins, Gregory R, Perry, Jillian L, Kai, Marc P, Chen, Kai, Bo, Tao, Napier, Mary E, Ting, Jenny P Y, Desimone, Joseph M, Bear, James E

“…Extended circulation of nanoparticles in blood is essential for most clinical applications. Nanoparticles are rapidly cleared by cells of the mononuclear…”
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Coordinate Regulation of Phospholipid Biosynthesis and Secretory Pathway Gene Expression in XBP-1(S)-induced Endoplasmic Reticulum Biogenesis by Sriburi, Rungtawan, Bommiasamy, Hemamalini, Buldak, Gerald L., Robbins, Gregory R., Frank, Matthew, Jackowski, Suzanne, Brewer, Joseph W.

“…Development of the expansive endoplasmic reticulum (ER) present in specialized secretory cell types requires X-box-binding protein-1 (Xbp-1). Enforced…”
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3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body by Oh, Hee Jeung, Aboian, Mariam S, Yi, Michael Y. J, Maslyn, Jacqueline A, Loo, Whitney S, Jiang, Xi, Parkinson, Dilworth Y, Wilson, Mark W, Moore, Terilyn, Yee, Colin R, Robbins, Gregory R, Barth, Florian M, DeSimone, Joseph M, Hetts, Steven W, Balsara, Nitash P

“…Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side…”
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Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model by Robbins, Gregory R., BS, PhD, Roberts, Reid A., BS, PhD, Guo, Haitao, BS, PhD, Reuter, Kevin, BS, Shen, Tammy, BS, PhD, Sempowski, Gregory D., BS, PhD, McKinnon, Karen P., BS, PhD, Su, Lishan, BS, PhD, DeSimone, Joseph M., BS, PhD, Ting, Jenny P.-Y., BS, PhD

“…Abstract Ideal nanoparticle (NP)-based drug and vaccine delivery vectors should be free of inherent cytotoxic or immunostimulatory properties. Therefore,…”
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Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance by Kai, Marc P, Brighton, Hailey E, Fromen, Catherine A, Shen, Tammy W, Luft, J. Christopher, Luft, Yancey E, Keeler, Amanda W, Robbins, Gregory R, Ting, Jenny P. Y, Zamboni, William C, Bear, James E, DeSimone, Joseph M

“…Long-circulating nanoparticles are essential for increasing tumor accumulation to provide therapeutic efficacy. While it is known that tumor presence can alter…”
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The Nucleotide-binding Leucine-rich Repeat (NLR) Family Member NLRX1 Mediates Protection against Experimental Autoimmune Encephalomyelitis and Represses Macrophage/Microglia-induced Inflammation by Eitas, Timothy K., Chou, Wei-Chun, Wen, Haitao, Gris, Denis, Robbins, Gregory R., Brickey, June, Oyama, Yoshitaka, Ting, Jenny P.-Y.

“…The nucleotide binding domain and leucine-rich repeat-containing (NLR) family of proteins is known to activate innate immunity, and the inflammasome-associated…”
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Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery by Shen, Tammy W., Fromen, Catherine A., Kai, Marc P., Luft, J. Christopher, Rahhal, Tojan B., Robbins, Gregory R., DeSimone, Joseph M.

“…Purpose We evaluated the role of a poly(ethylene glycol) (PEG) surface coating to increase residence times and alter the cellular fate of nano- and…”
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Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins by Robbins, Gregory R., Truax, Agnieszka D., Davis, Beckley K., Zhang, Lu, Brickey, W. June, Ting, Jenny P.-Y.

“…Most of the nucleotide-binding domain, leucine-rich repeat (NLR) proteins regulate responses to microbial and damage-associated products. Class II…”
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Mechanism for pre-B cell loss in VH-mutant rabbits by Robbins, Gregory R, Knight, Katherine L

“…Pre-BCR signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional IgH μ-chain are selectively expanded. B cell…”
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VH Gene Usage and Restricted B cell Development (138.4) by Robbins, Gregory R., Knight, Katherine L.

“…Signaling through the preBCR is an important checkpoint in B cell development in which the capacity for μ-chain to pair with surrogate light chain (SLC) is…”
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Mechanism for pre-B cell loss in mutant ali/ali rabbits by Robbins, Gregory R

“…Pre-B cell receptor (pre-BCR) signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional µ-chains undergo…”
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Mechanism for pre-B cell loss in mutant ali/ali rabbits by Robbins, Gregory R

“…Pre-B cell receptor (pre-BCR) signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional micro-chains undergo…”
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