Search Results - "Robbins, Brian L"

Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA by ROBBINS, B. L, SRINIVAS, R. V, KIM, C, BISCHOFBERGER, N, FRIDLAND, A

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Clinical Evaluation of a Dried Blood Spot Assay for Atazanavir by VAN SCHOONEVELD, Trevor, SWINDELLS, Susan, NELSON, Sarah R, ROBBINS, Brian L, MOORE, Ryan, FLETCHER, Courtney V

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Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC–MS/MS by Robbins, Brian L., Poston, Philip A., Neal, Erin F., Slaughter, Clive, Rodman, John H.

“…All nucleoside reverse transcriptase inhibitors (NRTI) must first be metabolized to their triphosphate forms in order to be active against HIV. Zidovudine…”
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Pharmacokinetics of High-Dose Lopinavir-Ritonavir with and without Saquinavir or Nonnucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors by ROBBINS, Brian L, CAPPARELLI, Edmund V, PELTON, Stephen I, ALDROVANDI, Grace, BORKOWSKY, William, RODMAN, John, HAVENS, Peter L, CHADWICK, Ellen G, YOGEV, Ram, SERCHUCK, Leslie, WORRELL, Carol, SMITH, Mary Elizabeth, ALVERO, Carmelita, FENTON, Terence, HECKMAN, Barbara

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Model for Intracellular Lamivudine Metabolism in Peripheral Blood Mononuclear Cells Ex Vivo and in Human Immunodeficiency Virus Type 1-Infected Adolescents by ZEXUN ZHOU, RODMAN, John H, FLYNN, Patricia M, ROBBINS, Brian L, WILCOX, Carrie K, D'ARGENIO, David Z

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Quantification of Cell-Associated Atazanavir, Darunavir, Lopinavir, Ritonavir, and Efavirenz Concentrations in Human Mononuclear Cell Extracts by PODANY, Anthony T, WINCHESTER, Lee C, ROBBINS, Brian L, FLETCHER, Courtney V

“…An ultrasensitive assay utilizing high-pressure liquid chromatography and mass spectrometry detection was developed and validated for the quantification of the…”
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Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS by Winchester, Lee C., Podany, Anthony T., Baldwin, Joshua S., Robbins, Brian L., Fletcher, Courtney V.

“…•Validated simultaneous LC/MS assay for rifabutin, rifampin and rifapentine.•High clinical utility to support pharmacokinetic and drug–drug interaction…”
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Measurement of plasma and intracellular concentrations of raltegravir in patients with HIV infection by SANDKOVSKY, Uriel, SWINDELLS, Susan, ROBBINS, Brian L, NELSON, Sarah R, ACOSTA, Edward P, FLETCHER, Courtney V

“…Paired plasma and intracellular samples were obtained from 12 HIV-infected adults taking raltegravir twice daily (b.i.d.), and after switching to once daily…”
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A rapid spin through oil results in higher cell-associated concentrations of antiretrovirals compared with conventional cell washing by Cory, Theodore J, Winchester, Lee C, Robbins, Brian L, Fletcher, Courtney V

“…Determination of cell-associated antiretroviral drug concentrations is necessary for research into reservoirs of HIV. Variation exists in cell-associated drug…”
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Development of a New Cartridge Radioimmunoassay for Determination of Intracellular Levels of Lamivudine Triphosphate in the Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Patients by ROBBINS, B. L, TRAN, T. T, PINKERTON, F. H, AKEB, F, GUEDJ, R, GRASSI, J, LANCASTER, D, FRIDLAND, A

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Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy by CHADWICK, Ellen G, YOGEV, Ram, ALVERO, Carmelita G, HUGHES, Michael D, HAZRA, Rohan, PINTO, Jorge A, ROBBINS, Brian L, HECKMAN, Barbara E, PALUMBO, Paul E, CAPPARELLI, Edmund V

“…To investigate the longitudinal pharmacokinetics, safety and efficacy of lopinavir/ritonavir (LPV/r) in HIV-infected infants initiating combination…”
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Nevirapine Plasma Concentrations in Human Immunodeficiency Virus-Exposed Neonates Receiving High-Dose Nevirapine Prophylaxis as Part of 3-Drug Regimen by Bolaris, Michael A, Keller, Margaret A, Robbins, Brian L, Podany, Anthony T, Fletcher, Courtney V

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A novel ultrasensitive LC–MS/MS assay for quantification of intracellular raltegravir in human cell extracts by Robbins, Brian L., Nelson, Sarah R., Fletcher, Courtney V.

“…An assay using ultrahigh pressure liquid chromatography and mass spectrometry detection was developed and validated for measurement of the HIV integrase…”
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Abacavir and Metabolite Pharmacokinetics in HIV-1-Infected Children and Adolescents by Cross, Shane J, Rodman, John H, Lindsey, Jane C, Robbins, Brian L, Rose, Charles H, Yuen, Geoffrey J, DʼAngelo, Lawrence J

“…OBJECTIVES:Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in…”
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Metabolism of Tenofovir and Didanosine in Quiescent or Stimulated Human Peripheral Blood Mononuclear Cells by Robbins, Brian L., Wilcox, Carrie K., Fridland, Arnold, Rodman, John H.

“…Objective. As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus‐1…”
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A new sensitive cartridge-RIA method for determination of stavudine (D4T) triphosphate in human cells in vivo by Tran, Thu T, Robbins, Brian L, Pinkerton, Frank H, Ferrua, Bernard, Grassi, Jacques, Fridland, Arnold

“…We describe a simple and sensitive method to determine stavudine triphosphate, the active intracellular anabolite of stavudine (D4T). Quantification of D4T…”
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Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology by ROBBINS, B. L, WEIBEL, B. H, FRIDLAND, A

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Cellular factors for resistance against antiretroviral agents by Fridland, A, Connelly, M C, Robbins, B L

“…Substantial advancements have been made in our understanding of the complex replication cycle of, and immunopathology associated with HIV infection as well as…”
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Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells by Connelly, M C, Robbins, B L, Fridland, A

“…The cellular uptake of phosphonylmethoxypropyl cytosine (HPMPC) was characterized to gain insight into the molecular properties that allow this…”
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A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent by Robbins, B L, Connelly, M C, Marshall, D R, Srinivas, R V, Fridland, A

“…9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a new antiviral agent with activity against herpes viruses and retroviruses, including human immunodeficiency…”
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