Search Results - "Robbie, Scott J"

Injectable intraocular telescope: Pilot study by Qureshi, Muhammad A., FRCS(Ophth), Robbie, Scott J., FRCOphth, PhD, Tabernero, Juan, PhD, Artal, Pablo, PhD

“…Purpose To assess the feasibility of a new injectable telescopic intraocular lens (IOL). Setting London Eye Hospital, London, United Kingdom. Design…”
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Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability by Nagai, Nori, Ju, Meihua, Izumi-Nagai, Kanako, Robbie, Scott J, Bainbridge, James W, Gale, David C, Pierre, Esaie, Krauss, Achim H.P, Adamson, Peter, Shima, David T, Ng, Yin-Shan

“…Choroidal neovascularization (CNV) is a defining feature of wet age-related macular degeneration. We examined the functional role of CCR3 in the development of…”
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Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency by Mihelec, Marija, Pearson, Rachael A, Robbie, Scott J, Buch, Prateek K, Azam, Selina A, Bainbridge, James W B, Smith, Alexander J, Ali, Robin R

“…Leber congenital amaurosis (LCA) is a severe retinal dystrophy manifesting from early infancy as poor vision or blindness. Loss-of-function mutations in GUCY2D…”
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CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization by Horie, Shintaro, Robbie, Scott J., Liu, Jian, Wu, Wei-Kang, Ali, Robin R., Bainbridge, James W., Nicholson, Lindsay B., Mochizuki, Manabu, Dick, Andrew D., Copland, David A.

“…Macrophages are rapidly conditioned by cognate and soluble signals to acquire phenotypes that deliver specific functions during inflammation, wound healing and…”
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Perineural infiltrates in Pseudomonas keratitis by Robbie, Scott J., PhD, FRCOphth, Vega, Felipe A., MD, Tint, Naing L., FRCOphth, Hau, Scott, BSc, MSc, MCOptom, Allan, Bruce, MD, FRCOphth

“…We describe 2 cases of contact lens–related microbial keratitis caused by infection with Pseudomonas aeruginosa in which perineural infiltrates were observed…”
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Dupilumab-Induced, Tralokinumab-Induced, and Belantamab Mafodotin–Induced Adverse Ocular Events—Incidence, Etiology, and Management by Mickevicius, Tomas, Pink, Andrew E., Bhogal, Maninder, O'Brart, David, Robbie, Scott J.

“…Emerging monoclonal antibody therapies are assuming greater importance in the management of severe and refractory forms of immunity-driven and oncological…”
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Combined rituximab and belimumab to treat recalcitrant epidermolysis bullosa aquisita associated with systemic lupus erythematosus by Tull, Thomas J, Benton, Emma C, Semkova, Kristina, Watson, Natalie A, Mee, John B, Lopez, Begona, Setterfield, Jane, Carey, Barbara, Ahmad, Sajjad, Robbie, Scott J, Groves, Richard W, Sanna, Giovanni, D'Cruz, David P

“…We report two cases of recalcitrant epidermolysis bullosa aquisita with associated systemic lupus erythematosus treated with combination rituximab and…”
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Initial Clinical Results With a Novel Monofocal-Type Intraocular Lens for Extended Macular Vision in Patients With Macular Degeneration by Robbie, Scott J, Tabernero, Juan, Artal, Pablo, Qureshi, Muhammad A

“…To determine the feasibility of a novel intraocular lens (IOL) designed to improve retinal image quality at up to 10° of retinal eccentricity and optionally…”
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Influence of Socioeconomic Deprivation on Visual Acuity in Patients Undergoing Corneal Transplantation by Robbie, Scott J, Jones, Mark N A, Larkin, Daniel F P

“…PURPOSE:To determine whether there is an association between socioeconomic status and best-corrected visual acuity (BCVA) in patients undergoing corneal…”
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IL-4 Regulates Specific Arg-1+ Macrophage sFlt-1–Mediated Inhibition of Angiogenesis by Wu, Wei-Kang, Georgiadis, Anastasios, Copland, David A, Liyanage, Sidath, Luhmann, Ulrich F.O, Robbie, Scott J, Liu, Jian, Wu, Jiahui, Bainbridge, James W, Bates, David O, Ali, Robin R, Nicholson, Lindsay B, Dick, Andrew D

“…One of the main drivers for neovascularization in age-related macular degeneration is activation of innate immunity in the presence of macrophages. Here, we…”
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An aspheric intraocular telescope for age-related macular degeneration patients by Tabernero, Juan, Qureshi, Muhammad A, Robbie, Scott J, Artal, Pablo

“…We have designed an intraocular telescope for the posterior chamber of the human eye of patients with age related macular degeneration. The basic design is…”
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Assessing a novel depot delivery strategy for noninvasive administration of VEGF/PDGF RTK inhibitors for ocular neovascular disease by Robbie, Scott J, Lundh von Leithner, Peter, Ju, Meihua, Lange, Clemens A, King, Andrew G, Adamson, Peter, Lee, Dennis, Sychterz, Caroline, Coffey, Pete, Ng, Yin-Shan, Bainbridge, James W, Shima, David T

“…Two noninvasive delivery strategies for VEGF/PDGF receptor tyrosine kinase inhibitors (RTKI) were explored that exploited uveal retention as a means for…”
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Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging by Robbie, Scott J, Georgiadis, Anastasios, Barker, Susie E, Duran, Yanai, Smith, Alexander J, Ali, Robin R, Luhmann, Ulrich F.O, Bainbridge, James W

“…Abstract The impact of many inflammatory diseases is influenced by age-related changes in the activation of resident and circulating myeloid cells. In the eye,…”
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Consecutive case series of 244 age-related macular degeneration patients undergoing implantation with an extended macular vision IOL by Qureshi, Muhammad A., Robbie, Scott J., Hengerer, Fritz H., Auffarth, Gerd U., Conrad-Hengerer, Ina, Artal, Pablo

“…Purpose: To determine safety and visual outcomes in eyes with age-related macular degeneration (AMD) implanted with a novel intraocular lens (IOL) that…”
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Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration by Luhmann, Ulrich F.O., Carvalho, Livia S., Robbie, Scott J., Cowing, Jill A., Duran, Yanai, Munro, Peter M.G., Bainbridge, James W.B., Ali, Robin R.

“…Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been…”
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Nature of the visual loss in observers with Leber's congenital amaurosis caused by specific mutations in RPE65 by Ripamonti, Caterina, Henning, G Bruce, Ali, Robin R, Bainbridge, James W, Robbie, Scott J, Sundaram, Venki, Luong, Vy A, van den Born, L Ingeborgh, Casteels, Ingele, de Ravel, Thomy J L, Moore, Anthony T, Stockman, Andrew

“…To characterize visual losses associated with genetic mutations in the RPE65 gene that cause defects in the RPE-specific isomerase, RPE65. RPE65 is an…”
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Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy by Ripamonti, Caterina, Henning, G Bruce, Robbie, Scott J, Sundaram, Venki, van den Born, L Ingeborgh, Casteels, Ingele, de Ravel, Thomy J L, Moore, Anthony T, Smith, Alexander J, Bainbridge, James W, Ali, Robin R, Stockman, Andrew

“…Restored rod visual function after gene therapy can be established unequivocally by demonstrating that, after dark adaptation, spectral sensitivity has the…”
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The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations by Luhmann, Ulrich Fo, Robbie, Scott J, Bainbridge, James Wb, Ali, Robin R

“…Systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis…”
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Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice by Barker, Susie E., Broderick, Cathryn A., Robbie, Scott J., Duran, Yanai, Natkunarajah, Mythili, Buch, Prateek, Balaggan, Kamaljit S., MacLaren, Robert E., Bainbridge, James W. B., Smith, Alexander J., Ali, Robin R.

“…Background Adeno‐associated virus serotype 2 (AAV2) vectors show considerable promise for ocular gene transfer. However, one potential barrier to efficacious…”
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Reply to comment on “Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration” by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80–87) by Luhmann, Ulrich F.O., Carvalho, Livia S., Robbie, Scott J., Bainbridge, James W.B., Ali, Robin R.

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