Search Results - "Robb Huhn, G."
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Endocytosis of the CdtA subunit from the Haemophilus ducreyi cytolethal distending toxin
Published in Cellular microbiology (01-11-2021)“…Many Gram‐negative pathogens produce a cytolethal distending toxin (CDT) with two cell‐binding subunits (CdtA + CdtC) and a catalytic CdtB subunit. After…”
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Acid-induced disassembly of the Haemophilus ducreyi cytolethal distending toxin
Published in Biochemical and biophysical research communications (25-12-2022)“…The cytolethal distending toxins (CDTs) produced by many Gram-negative pathogens are tripartite genotoxins with a single catalytic subunit (CdtB) and two…”
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Using Vibrio natriegens for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration
Published in Biochemistry (Easton) (05-03-2024)“…Production of soluble proteins is essential for structure/function studies; however, this usually requires milligram amounts of protein, which can be difficult…”
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Reduction is sufficient for the disassembly of ricin and Shiga toxin 1 but not Escherichia coli heat-labile enterotoxin
Published in Infection and immunity (16-11-2023)“…Many AB toxins contain an enzymatic A moiety that is anchored to a cell-binding B moiety by a disulfide bridge. After receptor-mediated endocytosis, some AB…”
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Acid‐Mediated Dissociation of Haemophilus ducreyi Cytolethal Distending Toxin Subunits Upon Cell Entry
Published in The FASEB journal (01-05-2021)“…Haemophilus ducreyi is a Gram‐negative bacterium responsible for the sexually transmitted disease chancroid. It releases a heterotrimeric cytolethal distending…”
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