Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mi...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 275; no. 5298; pp. 402 - 405
Main Authors:	Lasmezas, C.I. (Commissariat a l'Energie Atomique, Fontenay-aux-Roses, France.), Deslys, J.P, Robain, I, Jaegly, A, Beringue, V, Peyrin, J.M, Fournier, J.G, Hauw, J.J, Rossier, J, Dormont, D
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for the Advancement of Science 17-01-1997 American Association for the Advancement of Science The American Association for the Advancement of Science
Subjects:	Anatomy Animals Apoptosis Astrocytes - pathology Biological and medical sciences Bovine spongiform encephalopathy Brain Brain - pathology Brain Chemistry Cattle Cerebral hemispheres CEREBRO Creutzfeldt Jakob syndrome Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease transmission ENCEFALOPATIA ESPONGIFORME ENCEPHALE ENCEPHALOPATHIE SPONGIFORME Encephalopathy, Bovine Spongiform - metabolism Encephalopathy, Bovine Spongiform - pathology Encephalopathy, Bovine Spongiform - transmission Endopeptidases - metabolism Inoculum Lesions Medical sciences Mice Mice, Inbred C57BL Nerve Tissue Proteins - analysis Nervous system diseases Neurology Pathology Phenotype Physiological aspects Prions Prions (Proteins) Prions - analysis PROTEINAS PROTEINE Proteins Purkinje cells Purkinje Cells - pathology RATON Rodents Serial Passage SINTOMAS SOURIS SYMPTOME Time Factors TRANSMISION DE ENFERMEDADES TRANSMISSION DES MALADIES Vacuoles - pathology Animal model Nervous system diseases Molecular form Enzyme Rodentia Species specificity Cerebral disorder Infection Resistance Peptidases Vertebrata Mammalia Mouse Transmission from animal to animal Central nervous system disease Hydrolases Degenerative disease Prion Spongiform encephalopathy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres. During serial passage, PrPres appeared after the agent became adapted to the new host. Thus, PrPres may be involved in species adaptation, but a further unidentified agent may actually transmit BSE
Bibliography:	9718385 L73 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.275.5298.402